Signal Transduction Flashcards
1
Q
What are the 2 types of tyrosine kinase linked receptors?
A
Receptor tyrosine kinases
Cytokine receptors
2
Q
What do the phosphorylated tyrosine domains attract/activate?
A
Proteins with SH2 domains
3
Q
What does the phosphorylated intracellular Tyr by SH2(P) stimulate?
A
Protein Ras
4
Q
What does the Ras protein activate?
A
RAF signal transduction pathway
5
Q
What does the kinase cascade lead to?
A
Various transcription factors and gene transcription
6
Q
When does the kinase cascade become unregulated?
A
Cancer
