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BDS2 Applied Medical Sciences > Signal Transduction > Flashcards

Signal Transduction Flashcards

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USMLE® Step 1 flashcards
1
Q

What receptor is shown?

A

GPCR

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2
Q

Can the effector of a GPCR be an ion channel?

A

Yes

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3
Q

Where does the receptor exist in a GPCR?

A

Plasma membrane

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4
Q

What 2 receptors can the G protein activate?

A

Enzyme or ion channel

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5
Q

What are seconds messengers?

A

Transfer a signal from the membrane to the rest of the cell

After (receptor activation)

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6
Q

When the ligand activates the GPCR, is the signal continuous?

A

Yes

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7
Q

What is the chain of events in the GPCR?

A
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8
Q

What do second messengers do?

A
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9
Q

What are 4 examples of effectors in a GPCR?

A
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10
Q

What are examples of GPCR?

A
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11
Q

What is the second messenger of a denylate cyclase?

A

CAMP

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12
Q

What is reaction of adenylate cyclase to camp?

A

ATP to CAMP + PPi

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13
Q

Can adenylate cyclase link inhibitory and stimulatory receptors?

A

Yes

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14
Q

What are the stimulating receptors adenylate cyclase?

A

Beta adrenergjc

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15
Q

What are the inhibitory receptors of adenylate cyclase?

A

Alpha 2 receptors

Muscarunic

Opiate

GABA b

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16
Q

What does camp activate?

A

PKA

17
Q

What does the inhibitory GPCR cause?

A

Decreased HR

Inhibitory neurotransmitter release

Contraction I’d smooth muscle

18
Q

What is the effect of activating the inhibitory opioid GPCR?

A
19
Q

Where can the opioids affect?

A

Peripheral

Spinal

Supraspinal

20
Q

What is the best known opioid?

A

Morphine

21
Q

What is the most commonly prescribed opioid?

A

Codeine

22
Q

What are naturally occurring opioids?

A

Endorphins

23
Q

What are compounds related to opioids?

A

Methadone

Dimorphine (heroine)

Fentanyl

24
Q

What G protein activates PLC?

A

Gq

25
Q

What is the second messenger of PLC?

A

IP3
DAG

26
Q

What is the pathway of PLC in the GPCR?

A

BDS2 Applied Medical Sciences (37 decks)

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