Signal Transduction Flashcards
What receptor is shown?
GPCR
Can the effector of a GPCR be an ion channel?
Yes
Where does the receptor exist in a GPCR?
Plasma membrane
What 2 receptors can the G protein activate?
Enzyme or ion channel
What are seconds messengers?
Transfer a signal from the membrane to the rest of the cell
After (receptor activation)
When the ligand activates the GPCR, is the signal continuous?
Yes
What is the chain of events in the GPCR?
What do second messengers do?
What are 4 examples of effectors in a GPCR?
What are examples of GPCR?
What is the second messenger of a denylate cyclase?
CAMP
What is reaction of adenylate cyclase to camp?
ATP to CAMP + PPi
Can adenylate cyclase link inhibitory and stimulatory receptors?
Yes
What are the stimulating receptors adenylate cyclase?
Beta adrenergjc
What are the inhibitory receptors of adenylate cyclase?
Alpha 2 receptors
Muscarunic
Opiate
GABA b
What does camp activate?
PKA
What does the inhibitory GPCR cause?
Decreased HR
Inhibitory neurotransmitter release
Contraction I’d smooth muscle
What is the effect of activating the inhibitory opioid GPCR?
Where can the opioids affect?
Peripheral
Spinal
Supraspinal
What is the best known opioid?
Morphine
What is the most commonly prescribed opioid?
Codeine
What are naturally occurring opioids?
Endorphins
What are compounds related to opioids?
Methadone
Dimorphine (heroine)
Fentanyl
What G protein activates PLC?
Gq
What is the second messenger of PLC?
IP3
DAG
What is the pathway of PLC in the GPCR?
