Histology and Physiology of Muscles and Nerves - Skeletal Flashcards

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1
Q

What is the role of muscle cells?

A

Specialized contractile cells, generate motile forces through contraction

Move body parts or temporarily alter the shape of internal organs

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2
Q

What generates motile forces in muscles?

A

Motile forces are generated by the interaction of the proteins Actin and Myosin (Contractile proteins)

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3
Q

Name structures A-D

A

cross section shown

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4
Q

Name the structures in the histogram

A

A = A band
I = I band
C = capillary
N = nucleus
P = perimysium
Z = Z disc
E = endomysium
S = sarcomere
F = muscle fibre
SC = satellite cell
H = H zone
CT = connective tissue

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5
Q

What is the sarcomere?

A

A sarcomere is the most basic repeating structural unit of skeletal muscles and occurs between two Z lines of the actin and myosin filaments.

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6
Q

Name components A and B

A

A = Z disc
B - M line

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7
Q

Name structures A and B

A

A = I band
B = A band

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8
Q

Name structures A and B

A

A = thin filament
B = thick filament

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9
Q

Name structures A-C

A

A = A band
B = Z disk
C = I band

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10
Q

What type of muscle is this and name A and B

A
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11
Q

Where are the nuclei arranged in skeletal muscle?

A

Nuclei arranged at the cell periphery

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12
Q

What is contraction controlled by?

A

motor unit

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13
Q

What does the size of the fasciculi reflect?

A

function of the muscle

example

Ocular muscles – Small fasciculi & large
supporting tissue

Gluteal muscles– Large fasciculi & little
supporting tissue

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14
Q

What is a neuromuscular junction?

A

A neuromuscular junction (or myoneural junction) is a chemical synapse between a motor neuron and a muscle fiber

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15
Q

How is each skeletal muscle fibre contracted?

A

Each skeletal muscle fibre is contacted by a single nerve terminal from a motor neurone

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16
Q

How many muscle fibres does 1 motor neuron contact?

A

each motor neurone contacts many muscle fibres at motor end plates (= motor unit)

17
Q

What is Myasthenia Gravis?

A

autoimmune disorder

NMJ disintigrate

Antibodies produced against acetylcholine receptors

Increased weakening of skeletal muscles

18
Q

What disease cause weakening of the skeletal muscles?

A

Myasthenia Gravis

19
Q

What areas are effcted first by Myasthenia Gravis?

A

Muscles of the face, eyes and tongue are affected first

Muscles of respiration affects later lead to respiratory insufficiency

20
Q

What is a motor unit?

A

The combination of an individual motor neuron and all of the muscle fibers that it innervates

21
Q

What is shown in this diagram?

A

motor end plates

22
Q

What are muscle spindles?

A

are stretch receptors that signal the length and changes in length of muscles

Tell the brain how much the muscle is stretching or expanding.

regulate muscle tone

23
Q

What regulated muscle tone?

A

muscle spindle

24
Q

Are muscle spindle present in all skeletal muscles?

A

YES

25
Q

Where are muscle spindles numerous?

A

in fine precision movements (intrinsic muscles of the hand)

26
Q

Name components A and B

A
27
Q

What are the 2 types of skeletal muscle?

A

slow fibres
fast fibres

28
Q

What are slow fibres?

A

fatigue resistant
contract for along time

29
Q

What are fast fibres?

A

fatigue easily

30
Q

Decipher what fibre is fast and slow

A

A = slow
B = fast

31
Q

What is R and W? (muscle fibres)

A
32
Q

What are myofilaments?

A

Myofilaments are contractile proteins - actin & myosin

33
Q

What myofilament is thick?

A

myosin

34
Q

What myofilament is thin?

A

actin

35
Q

What is the repeating pattern myofibrils ?

A

cross-striations

36
Q

What creates the striations in skeletal muscle?

A

Striations are due to the highly ordered arrangement of contractile proteins (electron microscopy)

37
Q

Name structures A-G

A
38
Q

Describe the sliding filament theory

A

Energy released from ATP

Thick and thin filaments slide over one another

Causing shortening of contractile units – sarcomere – I band almost disappears

Large number of accessory proteins also play a part in filament alignment and regulation of contraction

39
Q

When ATP is bound to myosin, do the fibres contract?

A

YES