Olfactory System Flashcards
What type of receptors are for taste and smell?
Chemoreceptors
What can taste and to a lesser extent smell regulate?
GI secretions
Olfactory bulb
What is the messenger system used in olfaction?
G-protein second messenger system
What are the 7 primary qualities of smell?
Peppermint
Musk
Floral
Ethereal
Pungent
Putrid
Comphoraceous
What are the second order sensory neurons?
Mitral cells
Olfactory bulb
What do bi-directional projections give rise to?
Smell localisation
Where do olfactory pathways from the nose project to?
The cortex
When the Recepgor on cilia is activated, how is the calcium channel opened?
Via a GPCR, activates adenalate cyclase
What is the effect of Ca coming into the nerve?
Cause an AP, and depolarisation
What is the negative feedback system of Ca2+?
Activates calmldulin, inhibition of AC
What glamerulae are most highly activated?
Red and green
How is the what are the zones of the olfactory epithelium?
Zone I to IV in the olfactory bulb
In the retina, what is the difference in the caudal, and Rosetta’s receptors?
Sites for inhibitory ligand, highly expressed here. Expressed less in the restraints part
What does the vomeronasal organ detect?
Pheromones
How does the vomeronasal organ connect to the olfactory bulb?
Anterior to the posterior olfactory bulb
Does the vomeronasal organ signal to the olfactory in a gradient?
Yes
Do humans have a vomeronasal organ?
Likely no
What is the competitive model?
The trans olfactory neurones receptors are competed out, the ligand can’t bind the trans receptors..
What are olfactory sheathing cells?
Sheathing cells can support regeneration of olfactory bulb neurons
Could regenerate CNS
