Serotonin pharm

Question 1

Receptors of serotonin

Answer 1

1-7

Some are inhibitory and some are secretory

Question 2

SSRI use

Answer 2

Depression and chronic management of anxiety disorders

Question 3

Hydroxyzine

Answer 3

antihistamine used for anti anxiety

Question 4

Cyprohepatdine

Answer 4

Antihistamine blocking all of 5-HT types

Used in serotonin syndrome and carcinoid disease

Question 5

5-HT3 antagonists

Answer 5

Used as antiemetics in chemo

Question 6

Carcinoid syndrome

Answer 6

GI or bronchial tumors producing 5-HT

Diarrhea, flushing and hypotension, carcinoid heart disease, bronchospasm

Question 7

DOC for carcinoid syndrome

Answer 7

Ocreotide

Somatostatin analog

Question 8

5-HT1b/1d agonists

Answer 8

Inhibitor to 5-HT
-triptan
Used for migraine headaches
Vasoconstrict cerebral vasculature and decrease release of proinflammatory neuropeptides 
Acute attack management

Question 9

Adverse effects of migraine 5-HT agonists

Answer 9

Coronary vasospasms, infarction in patients with CAD, ischemia

Question 10

Ergotamine

Answer 10

Partial agonist at a1 and 5HT2 receptors
causes vasoconstriction action at CNS
Acute attack management

Question 11

First line prophylaxis treatment of migraines

Answer 11

Beta blockers: Propranolol
TCA’s: Amitryptiline
Anti-seizures: Valproate + Topiramate
Ca channel blocker: Verapamil