Exam 1 Flashcards
Volume of distribution
Amount of drug in the body/plasma drug concentration
High volume of distribution
Means that the drug is not highly protein bound
Clearance of a drug
0.693(Vd)/half life
Bioavailability
How much of the drug will reach the blood after metabolism
What form of drug route will have greatest bioavailability
IV and sublingual
Fastest route of absorption
Inhalation
What will make urine more acidic
Cranberry juice, vitamin C, NH4Cl
What will make urine more basic
Aspirin
What types of drugs will cross placenta and blood brain barrier
Small, lipid soluble, non-protein bound
Inhibition of CYP450 leads to
Drug toxicity
General inducers of CYP450
GPCRABS
Glucocorticoids, phenytoin, carbamazepine, rifampin, alcohol, barbiturates, st johns wort
General inhibitors of CYP450
GPACMANS
Grapefruit, protease inhibitors, proton pump inhibitors, azoles, cimetidine, macrolides, amiodarone, non-dihydropyridines, SSRIs
Drugs that undergo zero order elimination
Phenytoin, salicylates, aspirin, alcohol
Drugs that have a small therapeutic index
Have a higher chance of toxicity–need to monitor drug levels
Water percentage in neonates
75-80%, less body fat
When do kidneys and liver reach maturation in infants
2 years old
Before this, drug toxicity can occur more frequently
When does gastric output levels reach adult levels in children
2 years old
Gastric emptying in infants/children
prolonged
Pulmonary absorption in children
Decreased due to increased RR and larger tidal volume
Volume of distribution in children
Larger due to increased total body water and less albumin
Body water and fat in elderly
Less body water and more body fat
Half life of drugs may increase if higher volume of distribution
Drugs that have increased CNS effects in elderly
Anticholinergics, TCAs, antihistamines, antispasmodics, benzodiazepines, analgesics
Allosteric site
A binding site for substrates not active in initiating a response; may induce a conformational change in the structure of the active site, rendering it more or less susceptible to response from a substrate
Downregulation
Decreased availability of drug receptors
Enterohepatic recirculation
Process by which a drug excreted in the bile flows into the GI tract, where it is reabsorbed and returned to the general circulation
Hepatic extraction ratio
A comparison of the percentage of drug extracted and the percentage of drug remaining active after metabolism of the liver
Pharmacodynamics
Process through which drugs affect the nody
Pharmacokinetics
process through which the body affects the drug
Prodrug
A drug that is transformed from an inactive parent drug to an active metabolite
Penicillin’s
- Method of action
- SE
- Coverage
Bactericidal–interfere with cell wall synthesis
SE: hypersensitivity, GI distress, seizures, encephalopathy
Mostly G+ coverage
Some G- coverage
Cephalosporins
- Method of action
- SE
- Coverage
Bactericidal–interfere with cell wall synthesis
SE: hypersensitivity, GI distress
As you progress from 1st to 4th generation, has more G- and less G+ coverage
Monobactams
- Method of action
- SE
- Coverage
Bactericidal–interfere with cell wall synthesis
SE: GI distress, usually no cross-sensitivity with penicillin or cephalosporin
Primarily against G-
Carbapenems
- Method of action
- SE
- Coverage
most broad spectrum agents available
Bactericidal–interfere with cell wall synthesis
SE: neurotoxicity, GI distress
G+ , G-,
Fluoroquinolones
- Method of action
- SE
- Coverage
Bactericidal–Inhibit DNA gyrase and topoisomerase IV
SE: GI distress, dizziness, confusion, tendon rupture, QT prolongation
G+ and G-
DOC for UTI
Macrolides
- Method of action
- SE
- Coverage
Erythromycin, azithromycin, clarithromycin
Bacteriostatic–binds to 50S
SE: GI distress, hepatotoxicity, ototoxicity
Broad spectrum: G+, G-, Atypical
Aminoglycosides
- Method of action
- SE
- Coverage
Gentamicin, Neomycin, Streptomycin, Tobramycin
Bacteriostatic–binds to 30S
SE: Nephrotoxicity and ototoxicity
Mainly active against G-
Can combine with beta lactams for G+ coverage
Tetracyclines
- Method of action
- SE
- Coverage
Bacteriostatic–binds to 50S
SE: GI distress, gray-brown discoloration of the teeth
Broad spectrum–G+, G-, atypical
Sulfonamides
- Method of action
- SE
- Coverage
Bacteriostatic–inhibits folic acid
SE: GI distress, rash, fever, steven johnson syndrome and vasculitis
G+ and G- (except pseudomonas)
Vancomycin
- Method of action
- SE
- Coverage
Bactericidal–inhibits d-alanyl-d-alanine portion of cell wall
SE: fever, chills, phlebitis, red man syndrome, nephrotoxicity
Active mostly against MRSA
Oxazolidinones
- Method of action
- SE
- Coverage
Linezolid + Tedizolid Oral tx for MRSA Bacteriostatic--bind to 50S se: GI distress, thrombocytopenia, leukopenia G+ only--MRSA, VRE
Clindamycin
- Method of action
- SE
- Coverage
Bacteriostatic–binds to 50S
SE: diarrhea and C. DIff colitis
Active against G+ and G- anaerobic
Metronidazole
- Method of action
- SE
- Coverage
Bactericidal–inhibition of DNA protein synthesis
SE: GI distress, seizures, peripheral neuropathy
G- coverage only
DOC for abdomen and GU system (H Pylori, C. Diff, bacterial vaginosis, trich)
Chloramphenicol
- Method of action
- SE
- Coverage
Variably bactericidal–binds to 50S
SE: Gray baby syndrome, optic neuritis, fatal aplastic anemia
Broad spectrum: G+, G-, anaerobic
Rifampin
- Method of action
- SE
- Coverage
Variably bactericidal–inhibits DNA
SE: GI distress, headache, fever, discolors body fluids to orange
Mostly against G+ with some G- coverage
DOC for TB
Nitrofurantoin
Variably bactericidal–interfers with cell wall synthesis
SE: N/V and pulmonary reactions, hepatotoxicity, peripheral neuropathy
G+ only
Only used for uncomplicated UTI
Dermatitis
Alteration in skin reactivity caused by exposure to external agent; usually on inflammatory process
Diaper dermatitis, atopic dermatitis, irritant dermatitis
Linear streaks of papules, vesicles, and blisters that are very pruritic
First line therapy for dermatitis
Low potency topical steroid 2x a day
Alclometasone, flucinolone, hydrocortisone, triamcinolone
Prolonged use can cause skin atrophy
Second line therapy for dermatitis
Increase protency of topical steroid or increase to oral steroid
-Use in tapering dose for 2-3 weeks
Topical immunosuppressants for dermatitis
Primecrolimus + Tacrolimus
Used if patient can not tolerate steroids
Decreases cytokine transcription
Relief of itching in dermatitis
Antihistamines
Tinea
Group of fungi infections on skin
Pruritus, burning, stinging
First line therapy for tinea capitis
Griseofulvin
Systemic terbinafine or itraconazole
First line therapy for tina corporis, cruris and pedis
Topical azoles first
Systemic terbinafine or fluconaozle if no relief
First line therapy for tinea uriguium
Systemic terbinafine or itraconazole
Griseofulvin
Fungistastic
May aggravate SLE
SE: N/V, diarrhea, headache, photosensitivity
Tinea versicolor
Opportunistic superficial yeast infection; chronic; asymptomatic
Well-demarcated scaling patches of varied color due to overgrowth of yeast
DOC for tinea versicolor
Selenium sulfide
Candidiasis
Superficial fungal infection of skin and mucus membranes
Found commonly in diaper area, oral cavity, nails, vagina, penis
First line therapy for oral thrush
Nystatin–swish and swallow 3x a day for 10-14 days
First line therapy for skin candidiasis
Cool soaks with burrow solution, topical azole
If no relief, can use a systemic azole
Topical antivirals
Acyclovir, Penciclovir
Systemic antivirals
Acyclovir, Famciclovir, Valacyclovir
First line treatment for HSV-1
Topical acyclovir or penciclovir
Can use systemic if no releif
First line treatment for VZV
Systemic antiviral if <72 hours from outbreak, patient >50 years old, or immunocompromised
7 day treatment
First line treatment of warts
Salicyclic acid
-Keratolytic peeling agent; leave patch on 5-6 days a week for 12 weeks
Salicyclic acid CI in
Patients with DM or impaired circulation
Skin infections are primarily due to
Staph aureus, GAS, GBS
Impetigo
Superficial skin infection due primarily to staph aureus
Spread between close quarter living environments, poor hygiene, schools, daycare centers
Treatment of impetigo
Topical Mupirocin (Bactraban) for 7-10 days If more major, can give a broad spectrum penicillin or 1st generation cephalosporin
Cellulitis
Infection involving skin and subcutaneous layers and can spread systemically
Mostly due to staph aureus or GAS
Erysipelas
Superficial form of cellulitis that occurs in children due to GAS
Treatment of cellulitis without systemic symptoms or purulence
Penicillin or Augmentin
Treatment of cellulitis with purulent infection
Bactrim, minocycline, clindamycin, linezolid (covers MRSA)
Folliculitis
Superficial infection of hair follicle usually due to staph aureus
May be due to pseudomonas in hot tubs
Treatment for superficial folliculitis
Warm compresses, topical mupirocin ointment or topical gentamicin
Treatment for deeper folliculitis
Oral dicloxacillin, cephalexin, clindamycin
Necrotizing fasciitis
Serious infection of subcutaneous tissues that can be life threatening
Usually polymicrobial
Bactrim is not active against
GAS
Mupirocin ointment active against
Staph aureus and some strep
Topical gentamicin active against
Staph aureus, GAS, pseudomonas
Psoriasis
Autoimmune-mediated process driven by abnormally activated helper T cells
Well-demarcated, erythematous papules/plaques surrounded by silvery or whitish scales
First line treatment for psoriasis
Moisturizers + topical steroids
If no relief, can add a vitamin D analog
Topical corticosteroids for psoriasis
Hydrocortisone
Decreases redness, itching and scaling and promotes vasoconstriction
Rapid onset
Coal tars for psoriasis
Decrease DNA synthesis and has anti-inflammatory and anti-pruritic properties
Adjunct therapy to steroids
Has an unpleasant odor, staining and photosensitivity
Anthralin
Coal tar derivative used for psoriasis
Slow onset of action
Can irritate skin and stain clothing
Topical Vitamin D analogs for psoriasis
Calcipotrient + Calcipotriol
Mild-moderate psoriasis
Decreases cell proliferation and is anti-inflammatory
Can cause dry skin, peeling and rash
Retinoid
Vitamin D derivative Topical format for mild to moderate psoriasis Decreases inflammation Promotes longer remission May get worse before it improves
Systemic retinoids
Acitretin
Long term therapy for psoriasis
Decreases inflammation
Can cause liver and lipid problems, alopecia, skin peeling, dry skin and pruritus
Methotrexate for psoriasis
Treats generalized psoriasis
Inhibits folic acid reductase
Cyclosporine for psoriasis
Immunosuppressant
Used short term for exacerbation
May cause gingival hyperplasia, htn, nephrotoxicity, tremor
Acne Vulgaris
Excess androgen causes increased sebum production
Open comedones
Blackheads
Closed comedones
White heads
Comedolytics for Acne
Retinoic Acid (Tretinoin)
Adapalene Gel
Tazarotene Gel
Comedolytic bactericidals for Acne
Benzoyl peroxide
Azelaic acid
Topical antibiotics for acne
Clindamycin or erythromycin
Oral antibiotics for acne
Tetracycline
Erythromycin
Indicated for inflammatory acne
Isotretinoin
Reserved for severe nodulocystic acne when other treatments fail
Therapy usually occurs for 15-20 weeks
Severely teratogenic
First line therapy for acne
Topical antibiotics of comedolytics
Second line therapy for acne
Oral antibiotics and topical medications
Oral contraceptives
Third line therapy for acne
Isotretinoin
Who should not use tetracyclines
Children <12 years old
Pregnant women
Rosacea
Acneiform disorder that begins in midlife
Symmetric rash on central part of face
Treatment of rosacea
Topical metronidazole, sodium sulfacetamide, and acelaic acid first line
Oral doxycycline, erythromycin, bactrim for second line
Blepharitis
Eyelid margin infections usually due to staph aureus
Irritated red eyes, burning sensation, increased tearing
Treatment of blepharitis
Topical ophthalmic antimicrobials:
- Erythromycin ointment
- Bacitracin ointment
- Fluoroquinolone solution
Most common bacterial organisms of conjunctivitis
Staph, strep, moraxella, Haemophilus
N. gonorrhoeae and C. trach (for neonates)
Conjunctivitis usually due to
Virus
Profuse watery discharge
Treatment of bacterial conjunctivitis
Erythromycin or bacitracin ointment first line
ophthalmic fluoroquinolones for second line
Treatment of seasonal conjunctivitis
Topical antihistamines first line
Low potency topical corticosteroids for second line
T
Treatment of viral conjunctivitis
Topical antihistamines for first line
Low potency topical steroids for second line
Topical antibiotics for bacterial conjunctivitis
Erythromycin or bacitracin-polymyxin B ointment
Ophthlamic fluoroquinolones
Treatment of gonococcal conjunctivitis
IM ceftriaxone and oral azithromycin
Treatment of chlamydial conjunctivitis
Azithromycin or 7 days of doxycycline
Cromolyn for allergic conjunctivitis
Decreases inflammation and inhibits hypersensitivity
Mast cell stabilizer
Dry eye syndrome
Bilateral disruption of tear film on ocular surface can be due to decreased tear production, increased tear evaporation or combination
First line treatment for dry eye syndrome
Artificial tears 4x a day
If no relief, topical cyclosporine emulsion 2x a day
Cholinergic agonists for dry eye
Pilocarpine
Increased secretions
Glaucoma
Irreversible damage to optic nerve and retinal ganglion cells
Results in loss of visual sensitivity and field
Increased IOP due to increased aqueous humor
Treatment of glaucoma
Topical prostaglandins first line
Topical beta blocker + prostaglandin second line
Carbonic anhydrase inhibitor third line
Topical prostaglandins for glaucoma
-prost
Increases aqueous outflow
Can cause discoloration of iris
Topica Beta blockers for glaucoma
Decreases production of aqueous humor
May be absorbed systemically and cause bradycardia, hypotension, heart block and bronchospasm
Otitis media most frequent organisms
H. influenzae, S. pneumoniae, M. Catarrhalis
Less commonly due to s. aureus or GAS
DX of otitis media
Fever, otalgia, irritability, tympanic membrane is red, bulging and immobile
First line treatment for symptomatic otitis media
high dose amoxicillin or Augmentin
Recurrent otitis media
> 3 episodes within 6 months of >4 episodes in 12 months
Antibiotic prophylaxis not recommended
Vaccines important for prevention of acute otitis media
Pneumococcal, H. influenzae B, influenza
Otitis externa treatment
Topical antibiotics usually adequate: Fluoroquinolone drops (first line due to anti-pseudomonal coverage), Neomycin/Polymyxin combo second line
Do not use neomycin combo in otitis externa if
Tympanic membrane not in tact
1st line treatment for viral or bacterial upper airway infection
Decongestant
1st line treatment for allergic rhinitis
Antihistamines
Leukotriene inhibitors can also be used but they take longer
Decongestants
Stimulate alpha adrenergic receptors and cause vasoconstriction
Pseudoephedrine–can also relax the bronchi by agonizing B2
Do not give decongestants to
glaucoma patients, hypertension, CAD, BPH
Antihistamines
Used to treat IgE mediated allergies
Decreases redness, swelling, mucus production
Anticholinergic properties
Do not use for lower respiratory infections
Intranasal cromolyn
Decreases inflammation
Takes longer–not for acute cases
Does not have antihistamine, bronchodilator, vasoconstrictor or glucocoritcoid activity
Montelukast
leukotriene receptor inhibitor
Effective when exposure not avoidable
Antitussives
Codeine and dextromethorphan
Act on cough center of the medulla
Tessalon Perles
Anesthetize stretch receptors in the respiratory passages reducing cough reflex
Antitussives CI in
Productive cough, history of substance abuse, COPD
SE of antitussives
Dizziness, nausea, drowsiness, sedation
Expectorants
Guaifenesin
Increased respiratory tract fluid secretions
Loosen bronchial secretions
70% of URI are
Viral
Educate about hand washing, increasing fluids
Can give benzonatate for antitussive
First line treatment for cough
Decongestant and 1st generation antihistamine
Naproxen may decrease inflammation and cough
Do not use codeine for URI, only bronchitis
First line therapy for bacterial rhinosinusitis
Augmentin for 14 days
If no relief in 8 days can change to doxycycline, or fuoroquinolone
1st line treatment for URI
Topical decongestants for first 3 days, antipyretics, NSAIDS (naproxen)
If not better in 8-10 days, can try an antibiotic
What medications should be avoided in children
Sustained release, cough medicine <6 years old, 1st generation antihistamines, intranasal corticosteroids
What medications should be avoided in pregnant women
Decongestants, antitussives, expectorants
Antihistamines are category B
Most common pathogen of common cold
Rhinovirus
FEV1 concerning number
<80% treat
<50% emergency care
What can exacerbate asthma
Inhaled allergens, food, NSAIDs, cold air, exercise, airway irritants
Intermittent asthma
Symptoms <2 days per week
FEV >80%
Mild persistent asthma
Symptoms >2 days per week
FEV >80%
Moderate persistent asthma
Daily symptoms
FEV >60%
Severe persistent asthma
Continuous daily
FEV <60%
Initial treatment for asthma
inhaled corticosteroid
Then try leukotriene modifier or LABA
When having an acute asthma attack,
Use SABA
Long term control of asthma
inhaled corticosteroids
Lowest dose possible
2-4 inhalations 2-4 times per day
Takes 2 weeks of continuous therapy to achieve maximum effectiveness
SE of inhaled corticosteroids
Oral candidiasis, dysphonia, hoarseness, headache
Systemic corticosteroids
Used for severe exacerbations for 5 days-2 weeks
Short acting Beta agonist
albuterol
Long acting beta agonist
Formeterol, Aformeterol, salmeterol
SE of systemic corticosteroids
Sodium and water retention, hyperglycemia, increased appetite, weight gain, fractures in elderly
SE of leukotriene modifier drugs
Headache is common
Methylxanthines
Theophylline + Aminophylline
Relaxes bronchial smooth muscle, anti-inflammatory
Vaccines for patients with asthma
Annual influenza vaccine, 23 valent and 13 valent pneumococcal vaccine
COPD s/s
Morning cough with yellow sputum, frequent URI, prolonged expiration with wheezes and may hear crackles
Bronchodilators for COPD
SABA, LABA, Short acting anticholinergic (ipatropium), long acting anticholinergic (tiatropium)
Medications for maintenance of COPD
Anticholinergics, beta agonists, methylxanthines, corticosteroids (last effort)
Stage 1 COPD tx
Short acting bronchodilator
Stage 2 COPD tx
Regular use of long acting bronchodilator in addition to SABA
Stage 3 COPD tx
Add an ICS for frequent exacerbation
Stage 4 COPD tx
Add long term oxygen
Category B respiratory medications
Ipatropium, mast cell stabilizer, budesonide, montelukast, terbutaline
When are antibiotics indicated for COPD
If increased dyspnea, increased sputum, purulent sputum
Most commonly due to H. influenzae, S. pneumoniae, m/ catarrhalis
Acute bronchitis
95% due to virus
Edamatous mucus membranes, increase in bronchial secretions, crackles, rhonchi, wheezing, normal chest x ray
Treatment supportive
Only give antibiotics for acute bronchitis if
COPD, purulent sputum, respiratory symptoms >4-6 days
Chronic bronchitis
> 3 months every year in the past 2 years
Tx of bacterial cause of exacerbation of uncomplicated chronic bronchitis
Ampicillin first line
Tx of complicated chronic bronchitis
Augmentin, 2nd or 3rd generation cephalosporin, doxycycline
Tx of severe chronic bronchitis
Levo or cipro
Most common cause of community acquired pneumonia
S. Pneumoniae
Empiric treatment for CAP
Should always cover S. Pneumoniae and treat for 7-14 days
1st line treatment for CAP
Macrolide
Doxycycline or fluoroquinolone if recent antibiotic
1st line treatment for influenza
Oseltamivir or Zanamivir
Preventive measures for patients with asthma
Flu vaccine, pneumococcal vaccine, avoid smoking and allergens
If patient comes in with influenza..
Appropriate to give antivirals within 48 hours
More than that time is ineffective
SE of corticosteroids
Moon face, high blood pressure, high glucose, fractures, immunosuppression, growth issues in children
DOC for bacterial rhinosinusitis
Amoxicillin or Augmentin
If allergies–Macrolide
If you give a bronchodilator to an asthma patient, look out for
Tachychardia
SE of a beta blocker
Bradycardia, bronchoconstriction
How to distinguish viral from bacterial
Type of sputum, length of time, fever presence
How long to treat bacterial sinusitis
14 days
which drugs warrant monitoring drug levels due to narrow therapeutic index
Dilantin, warfarin, vancomycin, digoxin
How many half lives are needed on average to get rid of a drug from the body
5
If an elderly person has liver disease..
Concerned with drug toxicity due to less albumin so more free drug
When should you treat otitis media
If purulent discharge, fever, getting worse
Don’t need to treat if no exudate, tympanic membrane visible, no fever
Isoniazid SE
Neurotoxicity
Can give Vitamin B6 to prevent nerve damage
Fluorescein test
Eye exam to look for foreign object
Use a wood lamp to look into the eye