Antivirals

Question 1

Treatment for Herpes zoster

Answer 1

Acyclovir

Question 2

Acyclovir

Answer 2

Guanosine analog prodrug
Topical, oral or IV
Good distribution in body fluids including CSF
Short 1/2 life

Question 3

Adverse effects of acyclovir

Answer 3

N/V, diarrhea, headache

Can cause nephrotoxicity, neurotoxicity, and severe thrombocytopenia when given IV

Question 4

Ganciclovir

Answer 4

Treatment of CMV
Oral, IV and intraocular
Adverse effects: bone marrow suppression

Question 5

5 major classes of drugs for HIV

Answer 5

Nucleoside reverse transcriptase inhibitors
Non-nucleoside reverse transcriptase inhibitors
Protease inhibitors
Integrase inhibitors
Entry inhibitors

Question 6

Examples of NRTI

Answer 6

Zidovudine, Stavudine, Emtricitabine, Lamivudine, Didanosine, Tenofovir, Abacavir

Question 7

Examples of NNRTI

Answer 7

Nevirapine, efavirenz, delavirdine, etravirine

Question 8

All protease inhibitors cause

Answer 8

Insulin resistance

Question 9

Examples of protease inhibitors

Answer 9

atazanavir, Indinavir, Nelfinavir, Ritonavir

Question 10

Examples of integrase inhibitors

Answer 10

Raltegravir, Elvitegravir, Dolutegravir

Question 11

Side effects of integrase inhibitors

Answer 11

Can cause myopathy and rhabdomyolysis

Question 12

Combo therapy for HIV

Answer 12

2-3 drugs to decrease viral load

Most common initial tx: tenofavir and emtricitabine

Question 13

How to prevent prenatal transmission of HIV

Answer 13

Zidovudine administered to mother during pregnancy, L+D and to newborn
Avoid breastfeeding

Question 14

Influenza treatment

Answer 14

amantadine and rimantadine

Zanamivir and Oseltamivir

Question 15

Treatment of Hep B

Answer 15

Nuceloside/nucleotide analogs

Interferon a

Question 16

First line treatment of Hep B

Answer 16

Pegylated interferon a
Entecavir
Tenofavir
Emtricitabine

Question 17

Hep C treatment

Answer 17

IFN a
Ribavirin
Boceprevir