Antiepileptics

Question 1

Phenytoin

Answer 1

Used to treat any seizure except absence
Blocks voltage gated sodium channels by keeping them in inactivated state
Similar to 1B antiarrhythmic drugs
Zero order elimination

Question 2

Adverse effects unique to phenytoin

Answer 2

Gingival hyperplasia and hirsutism

Question 3

Carbamazepine

Answer 3

Similar therapeutic uses to phenytoin
DOC for trigeminal neuralgia
Used for bipolar manic phase

Question 4

Adverse effect unique to carbamazepine

Answer 4

SIADH

Question 5

Black box warning for carbamazepine

Answer 5

Rashes including steven johnson and aplastic anemia

Question 6

Valproic Acid

Answer 6

Used for all types of seizures including absence
Inhibits GABA transaminase to increase GABA
Inhibits T type Ca channels and voltage gated Na channels

Question 7

Unique SE of Valproic acid

Answer 7

alopecia, pancreatitis, hepatotoxicity, thrombocytopenia

Question 8

Ethosuximide

Answer 8

only used for absence seizures

T type Ca channel blocker