Antimicrobials: Nucleic Acid Synthesis Inhibitors

Question 1

Folic acid synthesis inhibitors

Answer 1

Sulfonamides, Dihydrofolate reductase inhibitors

Question 2

Direct acting nucleic acid inhibitors

Answer 2

Quinolones, Nitrofurantoin, Rifamycins

Question 3

Sulfonamides

Answer 3

Broad spectrum, bacteriostatic
Rapidly absorbed orally
Have high albumin binding–can cause kernicterus in neonates

Question 4

Adverse effects of sulfonamides

Answer 4

hypersensitivity, photosensitivity, acute hemolysis

Question 5

Combination of sulfonamide and DHF reductase inhibitor

Answer 5

Synergy and decreased resistance
Trimethoprim and sulfamethoxazole
Pyrimethamine + Sulfadiazine: DOC for toxoplasmosis

Question 6

Quinolones

Answer 6

All have “flox” in name
Bactericidal
Distributed to all tissues and bones

Question 7

Adverse effects of quinolones

Answer 7

Tendonitis, tendon rupture, increased QT

Question 8

Quinolones contraindicated in

Answer 8

Children and pregnancy

Question 9

Quinolones uses:

Answer 9

UTI/gastroenteritis, osteomyelitis, skin infection