Antihyperlipidemias

Question 1

Primary goal of antilipidemic therapy

Answer 1

Decrease LDL cholesterol

Question 2

New guideline to lower LDL

Answer 2

Moderate to high intensity statin therapy to decrease atherosclerotic CV risk in adults who have clinical atherosclerotic disease, LDL >190, diabetics aged 40-75

Question 3

VHDL is a

Answer 3

negative risk factor for coronary artery disease

Question 4

Statins

Answer 4

HMG-CoA reductase inhibitors
Inhibits rate limiting step in endogenous cholesterol synthesis–liver increases uptake of cholesterol from plasma causing decreased plasma LDL level

Question 5

Adverse effects of statins

Answer 5

hepatotoxicity

myopathy-muscle pain

Question 6

Fibrates

Answer 6

PPAR-a agonists, which induce lipoprotein lipase and promote catabolism of VLDL

Question 7

Examples of fibrates

Answer 7

Gemfibrozil and Fenofibrate

Question 8

Cholestyramine

Answer 8

Bile acid sequestrant
Decreases intrahepatic cholesterol pool increases LDL receptor gene expression which clears LDL from plasma
Very poorly tolerated due to fat malabsorption

Question 9

Niacin

Answer 9

Can give in high doses to lower lipids

Question 10

Statins and pregnancy

Answer 10

May be teratogenic