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Pharmacology > Antihistamines > Flashcards

Antihistamines Flashcards

1
Q

H1 stimulation on endothelium

A

NO synthase (dilation of vessels), increased Ca causing capillary permeability and edema

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2
Q

H1 stimulation on bronchiolar smooth muscle

A

Contraction

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3
Q

H1 stimulation on gut smooth muscle

A

Contraction

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4
Q

H1 stimulation on peripheral nerve endings

A

Pain and itching

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5
Q

H1 stimulation on AV node

A

Decreased conduction

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6
Q

H1 stimulation explains

A

Anaphylaxis and shock

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7
Q

H2 stimulation

A

Increased H+ secretion on parietal cells

Increased firing rate and contractility of heart

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8
Q

H1 stimulation on CNS

A

Increases wakefulness

Explains sedative effects of antihistamines that can cross bbb

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9
Q

Diphenhydramine

A

Competitive blocker of H1

Anti motion sickness and marked sedation

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10
Q

Legitimate use of antihistamines

A

allergy, urticaria, sleep aid

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11
Q

Fexofenadine, Loratadine Cetrizine

A

Antihistamines that do not enter CNS and do not cause sedation

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Pharmacology (56 decks)

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