Schizo Flashcards
Drugs that can cause or worsen psychotic symptoms
7 key drugs
- Anticholinergics centrally acting, high doses
- Cannabis
- Dextromethorphan
- Dopamine or dopamine agonists, Requip, Mirapex, Sinemet
- Interferons
- Stimulants
- Systemmic roids
Positive symptoms of Schizo? 3
- Hallucinations
- Delusions
- Disorganized thinking or behavior
What is tardive dyskinesia?
What do you do?
Abnormal facial movements tongue or mouth
Give SGA with low TD risk: Quitiapine, Clozapine
Important adverse effects of SGAs?
Highest risk for metabolic SEs? 3
- Clozapine
- Olanzapine
- Quitiapine
SGAs that have lower risk of metabolic adverse effects? 4
- Aripiprazole
- Ziprasidone
- Lurasidone
- Asenapine
Lowest risk of EPS SEs for SGAs?
Quitiapine DOC for PD patietns
Hemotologic effects of SGAs 1
Highest risk: Clozapine agranulocytosis
SGA with highest risk of QT prolongation?
Ziprasidone
SGAs that increase prolactin? 2
- Paliperidone
- Risperidone
SGA with highest risk of seizures?
Clozapine
Clozaril?
Clozapine
Abilify maintenna?
Aripiprazole IMm give monthly
When is clozapine used?
Used no sooner than 3rd line due to adverse effects
Lurisidone is what?
Nearly wt, lipid and blood glucose neutral
To start clozapine?
ANC must be >= 1500
Stop therapy if ANC is below 1000