Cancer Flashcards
Prevalent toxicities BCDMN
IP
VT
BMS
- Bleomycin, busulfan, carmustine, lomustine
- Cisplatin, carboplatin: nephro/ototox
- Doxorubicin and other anthracyclines: cardiotoxic
- MTX: Mucositis
- Nitrosoureas (lomustine, carmustine: hemorragic cystitis
- Vinc and taxanes: peripheral neuropathy
- Bone marrow suppression (BMS)
What are the age ranges for breast cancer screenings?
40-44
45-54
>=55
Diarrhea 3 drugs
Fluorouracil, capecitabine, irinotecan
I Flu to CAPE cod and RAN TO THE CAN
Mucositis
4 main meds and this class that ends in what?
Fluorouracil
capecitabine
irinotecan
MTX
TKIs end in nib
Neuropathy
3 classes
3 drugs
2
3
Vinca alkaloids, Vinecristine, vinblastine, vinorelbine
Platinums: cisplatin, oxaliplatin
taxanes: Paclitaxel, docetaxel, cabazitaxel
When should a 43 yo female get a mammogram?
Annual mammograms are optional
Nausea and Vomiting
What 3 drugs cause N/V the most?
Cyclophosphamide, cisplatin. ifosfamide
Thromboembolic risk
SERMS and aromatase inhibitors (anastrozole, letrozole)
SERMS: Tamoxifen
Lung cancer age range for screening?
55-74
Myelosuppression
Most chemo drugs do but what three dont?
Almost all expect Bleomycin, aspariginase, and vinctristine
Hemorragic cystitis
2 drugs and specific dosing
Ifosfamide: all doses
Cyclophosphamide: hgiher doses> 1 gram/m2V
When should a 47 yo get a mammogram?
Begin yearly mammograms
WHen should a 57 yo F get mammograms?
q 2 years or continue annually
Cardio toxicities
2 categories
1 in one cat
2 in the other
Anthracyclines cardiomyopathy
arsenic trioxide, TKIs ending in nib: QT prolongation
Constipation
Vinecristine
What is the criteria for getting a annual CT scan of the chest?
- In good health
- Have at least a 30 pack-year smoking history
- Still smoking or quit smoking within the past 15 years
Hepatotoxicity
Specific class and 3 within
Antiandrorgens (bocalutamide, flutamide, nilutamide)
Lifetime cumulative dose is 450-550 mg/m2 what is the drug and the reason?
Doxorubicin reason is cardiotoxicity
Single dose is capped at 2 mg what is the drug and the reason?
Vincristine and Neuropathy
Nephrotoxicity 2
Cisplatin, and MTX
When should a 47 year old pt get a colonoscopy?
Multi targeted DNA stool test?
Every 10 years
Stool every 3 years
Fecal occult blood test every year
Flexible sigmoidalscopy every 5 years
Dose per cycle is not to exceed 100 mg/m2
Cisplatin and nephrotox
Pulmonary toxicities
4
Bleomycin, busulfan, carmustine, lamustine
Lifetime cumulative dose is 400 units what is the reason and drug?
Bleomycin reason is pulmonary toxicity
What four chemo drugs commonly cause pulmonary fibrosis?
Bleomycin, Busulfran, Carmustine, Lamustine
What two drugs are nephro and ototoxic
Cisplatin, ototoxic
Cardio toxicity
Doxorubicin, and anthracyclines
Methotrexate
Mucositis
Hemorhagic cystitis
Nitrosuruea
Carmustine, Lamustine
Ifosfamide, Cyclophosphamide
Peripheral neuropathy
Vincas, Taxanes
What adjunctive medication is used for cisplatin and what does it prevent?
Amifostine (Ethyol)
What adjunctive medications are used for doxorubicin and what does it prevent?
Dextrazoxane (Zinecard) To prevent cardiomyopathy
Dextrazoxane (Totect) to treat extravasation
What is given with fluorouracil adn what does it do?
Leucovorin to enhance efficacy
What is the antidote for fluorouracil and capecitabine?
Uridine triacetate
What is added to ifosfamide and what is it for?
Mesna to prevent hemorrhagic cystitis
What can you do with cisplatin and ifosfamide?
Cisplatin to prevent nephrotoxicity
Ifosfamide to prevent cystitis
