ID 11 Flashcards
What 3 Abx types are concentration dependent killers
- AGs
- Quinolones
- Dapto
What 4 abxs are AUC:MIC dep
- Vanc
- Macrolides
- Tetracyclines
- Polymyxins
Only PCN active against Pseudomonas?
Zosyn
PCN class effects? 2 Cautions and such
- Avoid in beta-lactam allergy except pregnant patients with syphilis
- All PCns increase risk of seizure in renal impairment
Cephalosporins are not active againts?
Enterococcus
Oral outpatient cephalosporins? 3
- Gen Cephalexin
- Common uses skin infections with MSSA and strep through
- Cefuroxime: Acute otitis media, CAP, sinus infection
- CAP, sinus infection
Common uses for cefazolin?
Surgical prophylaxis
Parenteral
10 in patient pareneteral cephs
- 1st gen: Cefazolin
- 2nd gen Cefotetan, Cefoxitin
- 3rd gen: Ceftriaxone and Cefotaxime
- 3rd gen Ceftazidime, 4th gen Cefepime
- Ceftolozan/Tazo, Ceftaz/Avibactam
- Ceftaroline Only beta lactam active against MRSA
Class effects of Carbapenems? 4
- All cover ESBL producing organisms
- All except ertra cover pseudomonas
- Dont use with PCN allergy
- Seizure risk with higher doses, renal failure or use of imipenem/cilstatin
All carbapenems dont cover what 5 organisms?
Atypicals, VRE, MRSA, C. DIf, Stenotrophomonas
What 3 organisms does ertrapenem not cover?
PSeudomonas, Acinetobacter, or Enterococcus
3 common uses of Carbapenems
- Polymicrobial infections mod severe diabetic foot infections
- Empiric therapy when resistant organsims are suspected
- Resttant pseudomonas or Acinetobacter Not ertra
What monobactam can be used with PCN allergy?
Aztreonam
What are the 3 respiratory quinolones?
Moxi, levo gemi
8 abxs that do not require renal dose adjustments?
- Antistaph PCNS (dicloxacillin, nafcillin)
- Ceftriaxone
- Clindamycin
- Doxy
- Macrolides (azithro, erythro only)
- Metronidazole
- Moxi
- Linezolid