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NAPLEX > Asthma > Flashcards

Asthma Flashcards

1
Q

What rescue inhaler use Characterizes intermittent asthma severity?

A

<=2 days per week

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2
Q

What rescue inhaler use shows persistent mild severity?

A

> 2 days per week but not daily or >1x/day

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3
Q

What rescue inhaler use shows persistent moderate asthma severity?

A

Daily

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4
Q

What rescue inhaler use shows persistent severe severity?

A

Several times per day

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5
Q

What vaccines should asthma patients get?

A

Annual flu

Pneumovax 23

Patients should only get Prevnar if they are 6-18 who require high dose oral steroids

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6
Q

What drug is first line for all patients with persistent asthma?

A

ICS

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7
Q

What agent should never be used alone in asthma and is a preferred add on?

A

LABA

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8
Q

What drug is used for severe allergic asthma?

A

Mab: Omalizumab

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9
Q

When should you maintain current asthma therapy or consider step down?

A

Consider step down if controlled for at least 3 months

  • Symptom use: of SABA <= 2 days per wk, nightime <=2 days per wk , no limitations on activity
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10
Q

When should you consider stepping therapy up for asthma patients?

A

SABA > 2 days per wk

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11
Q

When should you consider stepping asthma therapy up 1-2 steps?

A

Using SABA several times a day

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12
Q

What is the recommended therapy for intermittent asthma? 2 things

A

SABA as needed

COnsider low dose ICS to prevent exacerbations

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13
Q

Step 2 what should be added for mild persistent asthma

A

Low dose ICS, controller

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14
Q

What should be added for Step 3 moderate persistent asthma?

A

Low dose ICS + LABA OR medium dose ICS

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15
Q

What should be addd in step four for persistent severe asthma?

A

Medium dose ICS + LABA

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16
Q

What should be added in step 5 fpr severe persistent asthma?

A

High dose ICS + LABA

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17
Q

Step 6 severe persistent asthma?

A

Add oral steroid

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18
Q

What is added for Step 1,2,3,4,5,6

A
  1. SABA, consider low dose ICS
  2. Add ICS for sure low dose
  3. Low dose ICS + LABA or increase ICS
  4. Increase dose of ICS +LABA
  5. Hign dose ICS + LABA
  6. Add oral sterois
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19
Q

Albuterol dosing?

A

MDI/DPI 1-2 inhalations Q4-6

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20
Q

Boxed warning for ProAir Respiclick?

A

Severe hypersens milk protein

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21
Q

SEs of albuterol? 7

A
  1. Nervousness
  2. Tremor
  3. Tachcardia
  4. Palpitations
  5. COugh
  6. Hyperglycemia
  7. Decreased K
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22
Q

Serevent Diskus?

A

Salmeterol

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23
Q

Boxed warning for serevent diskus?

A

Increase asthma related deaths only used in combo with asthma

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24
Q

Qvar

A

Beclomethasone

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25
Q

Pulmicort Flexhaler

A

Budesonide

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26
Q

Pulmicort Respules

A

Budesonide Nebulaizer

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27
Q

Flovent

Arnuity Ellipta?

A

Fluticasone

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28
Q

SEs of Inhaled corticosteroids? 3

A
  1. Dsyphania difficulty speaking
  2. Oral candiasis
  3. Cough
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29
Q

How to prevent oral candiasis in asthma?

A

Rinse mouth after use

use a spacer

30
Q

What is the only ICS available as a nebulizer?

A

Pulmicort respulesL Budesonide

31
Q

What is a high dose of QVAR?

A

>480 mcg

32
Q

What is a high dose of pulmicort?

A

>1080

33
Q

What is a high dose fluticasone MDI?

A

>440

34
Q

What is a high dose of fluticasone DPI?

A

>500

35
Q

What is a high dose of mometasone MDI

A

>400

36
Q

What is a high dose of mometasone DPI?

A

>440

37
Q

Special note about QVAR and Alvesco?

A

They do not need to be shaken

38
Q

Main ICSs for asthma? 3

A

QVAR, Pulmicort, Flovent

39
Q

One LABA used for Asthma and COPD

A

Salmeterol

Serevent

40
Q

4 combo ICS LABA for Asthma

A
  1. Symbicort
  2. Advair, Airduo
  3. Dulera
  4. Breo Ellipta
41
Q

Breo Ellipta?

A

Fluticasone/vilanterol

42
Q

Dulera

A

Mometasone/formeterol

43
Q

Advair, Airduo

A

Fluticasone/salmeterol

44
Q

What are the DPI names? 7

A
  1. Diskus
  2. Ellipta
  3. Pressair
  4. Handihaler
  5. Neohaler
  6. Respiclick
  7. Flexhaler
45
Q

What dosage forms does singulair com ein?

A

Tablet, chewable, packet

46
Q

3 dosing ranges for Singulair

A
  1. >14, 10 mg in the evening
  2. 6-14, 5 mg in the evening
  3. 1-5, 4 mg in the evenin
47
Q

Singlulair warning?

A

Neuropsych events

48
Q

Theophylline therapeutic levels

A

5-15 mcg/mL

49
Q

How do you convert theophylline to aminophylline

A

ATM amino to theo x 0.8

theo to amino / 0.8

50
Q

What 7 drugs can increase theophylline levels

A
  1. CYP1A2 inhibiton
  2. Ciprofloxacin
  3. fluvoxamine
  4. cimetidine
  5. propranolol
  6. zafirlukast
  7. zilueton
51
Q

Xolair

A

Omalizumab

52
Q

Xolair administration?

A

In a medical setting given SC

Anaphylaxis can occur

53
Q

What does Xolair do?

A

IgE binding inhibitoon

only for allergic asthma

54
Q

Who is at higher risk for developing COPD?

A

alpha-1 antitrypsin def

55
Q

Difference in asthma and COPD?

A

Asthma the limitation in airflow is medically reversible

COPD: Not fully reversible

56
Q

What is required for COPB diagnosis?

A

Spirometry

57
Q

What FVC confirms COPD?

A

FVC<70

58
Q

Pts exacerbation history and CAT/mMRC score to put them in category A

A

0 or 1 exacerbation not leading to hosptalization

CAT <10

mMRC 0-1

59
Q

Exacerbation hx to put you in COPD category A or B

A

0 or 1 not leading to hospitalization

60
Q

CAT and mMRC score putting you in category D or B

A

CAT>= 10

mMRC >= 2 `

61
Q

Exacerbation history to put you in category C or D

A

>= 2 exacerbations or 1 putting you in the hospital

62
Q

Recommended treatment for category A

A

SABA or SAMA PRN

63
Q

Category B treatment

A

LAMA or LABA

64
Q

Pt group C

A

LAMA

65
Q

Patient Group D

A

LAMA + LABA

66
Q

Atrovent HFA

A

Ipratropium

67
Q

Combivent REspimat

A

Ipratropium + albuterol

68
Q

Spiriva Handihaler

A

Tiotropium

69
Q

Brovana

A

Arformeterol R-Isomer of formeterol

70
Q

Daliresp

A

Roflumilast

71
Q

MOA of daliresp

A

PDE-4 inibitor incres cAMP redcing inflammation in the lungs

NAPLEX (64 decks)

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