Compounding

Question 1

What two forms of documentation must be had for compounded products?

Answer 1

1. Master Formulation Record (recipe with ingredients and instructions)
2. And Compounding record (log book of all products made within the pharmacy, components with lot numbers and expiration dates, BUD, description, duplicate label)

Question 2

Comminution:

Trituration:

Levigation

Pulverization by intervention

Answer 2

• Reduce particle size
• make homogenous
• addition of liquid (levigating agent) in small portions
• Used for crystalline powders (crystals are dissolved with an intervening solvent)

Question 3

Common powder excipients?

Answer 3

Glidant/lubricant: mg stearate

Surfactant: to neutralize static charge: sadium lauryl sulfate

Be careful with eutectic mixture because there melting point is reduced

Question 4

Capsule sizes

Answer 4

000 larges

5 smallest

Question 5

What topical contains the least water? Most?

Answer 5

Ointments

Lotions contain the most

Question 6

What are the 5 types of ointment types dependent on base?

Answer 6

1. Oleaginous (oily/greasy)
2. Absorption base
3. water in oil (w/o) emulsion base
4. oil in water (o/w) emulsion base
5. Water soluble bases

Question 7

To make a gel active ingredients are added to?

Answer 7

Pluronic lecithin organogel (PLO)

Question 8

Oil soluble Suppository bases

Water soluble

Answer 8

• Cocoa butter (theobroma oil)
• hydrogenated vegetable oils (palm, palm kernel, coconut oils)

Water

• polyethylene glycol (PEG)
• glycerinated gelatin

Question 9

What needs to be calculated for suppositories?

Answer 9

Density Factor

B/(A-C+B)

• A= weight of suppository in blank
• B= wt of medication per suppository
• Wt of medicated suppository

Question 10

What is a solution?

Answer 10

is a solute dissolved in a solvent, solutions are homogenous

syrups, elixirs

Question 11

What is a suspension?

Answer 11

a solid dispersed in a liquid

redispersed by shaking

Question 12

Emulsion?

Answer 12

Liquid dispersed in a liquid

Question 13

Reducing surface tension between and solid and liquid

Answer 13

wetting or levigating agent

Question 14

Reducing surface tension between oil and water

Answer 14

Emulsifier

Question 15

HLB balance scale and interpretation

Answer 15

0, 10, 20

below 10 more lipid soluble

above 10 more H2O soluble

Question 16

USP specifies refrigeration for what compounds?

Answer 16

water containing oral formulations only

Question 17

Nonaqueous formulation BUD

Answer 17

earliest experiation date or 6 months whichever is sooner

Question 18

Water containing oral formulations?

Answer 18

Store in fridge not later than 14 days

Question 19

Water-containing topical (creams/lotions)

BUD?

Answer 19

Not later than 30 days store at room temp

Question 20

Product labeling

Answer 20

Must include the BUD and storage instructions

Question 21

What must be the minimum air quality in PEC?

Answer 21

ISO 5

BUffer at least 7

Anteroom at least 8 if positive pressure, 7 if negative pressure

Question 22

What is the BUD for compounds made in segregated compounding areas?

Answer 22

BUD of 12 hours

Question 23

What is used during fingertip tests?

Answer 23

Trypticase soy agar (TSA)

Question 24

What is the osmolarity of human blood?

Answer 24

285 mOsmol/L

Question 25

When should non-PVC bags be used?

Answer 25

have leeching or siption issues

Question 26

Chemotherapy lableing

Answer 26

“Chemotherapy Dispose of Properly”

Question 27

Sterile BUD

Answer 27

Question 28

What are the 5 things to decide if something is Hazardous?

Answer 28

Carcinogenic

teratogenic

Reproductive toxicity

Organ toxicity at low dose

Genotoxic (damage to DNA)

Question 29

Torsion Balance Sensitivity REquirements

Answer 29

SR/Acceptable error rate (.05 or 5%)