Cancer

Question 1

Myelosuppression

3 that don’t cause it

Answer 1

Almost all expect Bleomycin, aspariginase, and vinctristine

Question 2

Nausea and Vomiting

Answer 2

Cyclophosphamide, cisplatin. ifosfamide

Manage with neurokinin-1 inhibitors, serotonin antagonists

dexamethasone, meclopramide

Question 3

Mucositis

Answer 3

Fluorouracil

capecitabine

irinotecan

Question 4

Constipation

Answer 4

Vinctristine

Stimulant laxative and polyethylene glycol;

Question 5

Cardio toxicities

Answer 5

Anthracyclines cardiomyopathy

arsenic trioxide: QT prolongation

Question 6

Pulmonary toxicities

Answer 6

Bleomycin, busulfan, carmustine, lamustine

Question 7

Hepatotoxicity

Answer 7

Antiandrorgens (bocalutamide, flutamide, nilutamide)

Question 8

Nephrotoxicity

Answer 8

Cisplatin, and MTX

Question 9

Hemorragic cystitis

Answer 9

Ifosfamide: all doses

Cyclophosphamide: hgiher doses> 1 gram/m2V

Question 10

Neuropathy

Answer 10

Vinca alkaloids,

Platinums

taxanes

Question 11

Thromboembolic risk

Answer 11

SERMS and aromatase inhibitors

Question 12

Prevalent toxicities BCDMN

IP

VT

BMS

Answer 12

• Bleomycin, busulfan, carmustine, lomustine
• Cisplatin, carboplatin: nephro/ototox
• Doxorubicin and other anthracyclines: cardiotoxic
• MTX: Mucositis
• Nitrosoureas (lomustine, carmustine: hemorragic cystitis
• Vinc and taxanes: peripheral neuropathy
• Bone marrow suppression (BMS)