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Lipid Flashcards

1
Q

What does clinical ASCVD include? 4

A
  1. CHD
  2. Stroke
  3. TIA or
  4. Peripheral arterial disease
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2
Q

CLinical ASCVD <= 75

Secondary prevention

A

High-Intensity statin

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3
Q

Clinical ASCV > 75

A

Moderate intensity statin

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4
Q

Primary prevention groups 3

A
  1. LDL >= 190
  2. DM age 40-75 years with LDL b/w 70-189
  3. Age 40-75 with LDL b/w 70-189
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5
Q

DM patients age 40-75 with lLDL b/w 70-189

10 year risk >= 7.5

A

High intensity

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6
Q

DM age 40-75 LDL b/w 70-189 10 year < 7.5

A

Mod

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7
Q

Age 40-75 LDL 70-189

10 year >= 7.5

A

Mod intensity

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8
Q

High intensity statins?

A

Ator 40-80

Rosu: 20-40

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9
Q

Max dose of simvastatin with Verapamil, diltiazem and dronedarone?

A

10 mg/day

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10
Q

Max dose of simvastatin with amiodarone, amlodipine, lomitapide, ranolazine

A

20 mg/day

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11
Q

What drug should be avoided with atrovastatin?

A

Cyclosporin

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12
Q

Increased risk of myopathys with statins and what other drugs?

A

Gemfibrozil: fenofibrates

Niacin

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13
Q

When should lovastatin be taken?

A

At night

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14
Q

What has been reported with what drug and statins?

A

Colchine

Rhabodo

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15
Q

What shouldnt be used in combination?

A

Gemfib and Statins

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16
Q

Zetia

A

Ezitamide

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17
Q

Drug interaction with zetia increase?

A

Cyclosporin interaction bith levels can increase

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18
Q

What can decrease ezitamide?

A

Bile acid sequesterants

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19
Q

What to do with admin of Zetia and BASs?

A

Give zetia 2 hours before or 4 hours after BASs

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20
Q

12 drugs to avoid with simvastatin and lovastatin?

A
  1. Itraconazole
  2. Ketoconazole
  3. Posaconazole
  4. Voriconazole
  5. Erythromycin
  6. Clarithromycin
  7. HIV proteas inhibitors
  8. Cobistat regimens
  9. Nefazodone
  10. Cyclosporine
  11. Danazol with simva
  12. Grapefruit juice
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21
Q

CrCl < 60 and vytorin?

A

max 20 mg/day with simva

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22
Q

Welchol

A

Colesevelam

23
Q

2 BASs

A

Cholestyramine

Colesevelam: Welchol

24
Q

What BAS is also approved for glycemic control in T2DM

25
Q

COntra to welchol?

A

Bowel obstruction

TG>500 hc of hyper tg induec pancreatitis

26
Q

How is welchol taken?

A

With a meal and liquid

27
Q

6 SEs of BASs

A

Constipation, ab pain, cramping, bloating, gas, Increased TGs

28
Q

What is considered an option for pregnant patietns?

29
Q

Cholestyramine and Colestipol Admin

A

take all other drugs 1-4 hours before or 4-6 hours after

30
Q

Welchol can increase the levels of what?

31
Q

BASs can decrease aborption of what 4 things

A

Fat soluble vits

ADEK

32
Q

Antara, TriCor, Trilipix

A

FEnofibrate

33
Q

What do fibrates mainly do?

A

Decrease TG significantly

34
Q

Lopid

A

Gemfibrozil

35
Q

3 contraindications for fibrates

A
  1. Severe renal disease including primary biliary cirrhosis
  2. Severe renal CrCL < 30
  3. Gallbladder dx
36
Q

2 main warnings of fibrates?

A

Myopathy: which is increase when given with statins

37
Q

What 2 drugs should not be given with gemfibrozil?

A

Zetia and Statins

38
Q

Gemfibrolsil is contraindicated with what other drug?

A

Repaglinitide

39
Q

Fibrates can increase effects of what two drugs?

A

SUs

Warfarin

40
Q

Niacin

41
Q

Monitoring for Niacin?

A

Check LFTs hepatotox warning

42
Q

Risk of what at what dose for niacin?

A

Rhabdo >=1 g/day

43
Q

5 SEs of Niacin?

A
  1. FLushing
  2. Puritis itching
  3. N/V/D
  4. Incre BG
  5. Hyperuracemia or gout
44
Q

What Niacin formulation has less flushing and less hepato

45
Q

Controlled and sustained release naicin?

A

Has decreased flushing but increase hepatotox

46
Q

IR niacin has what

A

Poor tolerability due to flushing

47
Q

When is fish oil recommended?

A

Adjuct to diet when TGs>=500

48
Q

What is special with Lovaza?

A

Increase LDL up to 44%

49
Q

Fish oil interactioN?

A

Can increase bleeding time monitor INR if taken with warfarin

50
Q

Repatha?

A

Evolocumab

51
Q

When should you take Zocor and fluvastatin IR?

A

In the evening

52
Q

How to take lovastatin?

A

with evening meal

53
Q

When to take Altoprev?

A

at bedtime

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