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Lipid Flashcards

1
Q

What does clinical ASCVD include? 4

A
  1. CHD
  2. Stroke
  3. TIA or
  4. Peripheral arterial disease
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2
Q

CLinical ASCVD <= 75

Secondary prevention

A

High-Intensity statin

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3
Q

Clinical ASCV > 75

A

Moderate intensity statin

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4
Q

Primary prevention groups 3

A
  1. LDL >= 190
  2. DM age 40-75 years with LDL b/w 70-189
  3. Age 40-75 with LDL b/w 70-189
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5
Q

DM patients age 40-75 with lLDL b/w 70-189

10 year risk >= 7.5

A

High intensity

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6
Q

DM age 40-75 LDL b/w 70-189 10 year < 7.5

A

Mod

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7
Q

Age 40-75 LDL 70-189

10 year >= 7.5

A

Mod intensity

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8
Q

High intensity statins?

A

Ator 40-80

Rosu: 20-40

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9
Q

Max dose of simvastatin with Verapamil, diltiazem and dronedarone?

A

10 mg/day

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10
Q

Max dose of simvastatin with amiodarone, amlodipine, lomitapide, ranolazine

A

20 mg/day

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11
Q

What drug should be avoided with atrovastatin?

A

Cyclosporin

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12
Q

Increased risk of myopathys with statins and what other drugs?

A

Gemfibrozil: fenofibrates

Niacin

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13
Q

When should lovastatin be taken?

A

At night

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14
Q

What has been reported with what drug and statins?

A

Colchine

Rhabodo

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15
Q

What shouldnt be used in combination?

A

Gemfib and Statins

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16
Q

Zetia

A

Ezitamide

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17
Q

Drug interaction with zetia increase?

A

Cyclosporin interaction bith levels can increase

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18
Q

What can decrease ezitamide?

A

Bile acid sequesterants

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19
Q

What to do with admin of Zetia and BASs?

A

Give zetia 2 hours before or 4 hours after BASs

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20
Q

12 drugs to avoid with simvastatin and lovastatin?

A
  1. Itraconazole
  2. Ketoconazole
  3. Posaconazole
  4. Voriconazole
  5. Erythromycin
  6. Clarithromycin
  7. HIV proteas inhibitors
  8. Cobistat regimens
  9. Nefazodone
  10. Cyclosporine
  11. Danazol with simva
  12. Grapefruit juice
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21
Q

CrCl < 60 and vytorin?

A

max 20 mg/day with simva

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22
Q

Welchol

A

Colesevelam

23
Q

2 BASs

A

Cholestyramine

Colesevelam: Welchol

24
Q

What BAS is also approved for glycemic control in T2DM

25
COntra to welchol?
Bowel obstruction TG\>500 hc of hyper tg induec pancreatitis
26
How is welchol taken?
With a meal and liquid
27
6 SEs of BASs
Constipation, ab pain, cramping, bloating, gas, Increased TGs
28
What is considered an option for pregnant patietns?
Welchol
29
Cholestyramine and Colestipol Admin
take all other drugs 1-4 hours before or 4-6 hours after
30
Welchol can increase the levels of what?
Metformin
31
BASs can decrease aborption of what 4 things
Fat soluble vits ADEK
32
Antara, TriCor, Trilipix
FEnofibrate
33
What do fibrates mainly do?
Decrease TG significantly
34
Lopid
Gemfibrozil
35
3 contraindications for fibrates
1. Severe renal disease including primary biliary cirrhosis 2. Severe renal CrCL \< 30 3. Gallbladder dx
36
2 main warnings of fibrates?
Myopathy: which is increase when given with statins
37
What 2 drugs should not be given with gemfibrozil?
Zetia and Statins
38
Gemfibrolsil is contraindicated with what other drug?
Repaglinitide
39
Fibrates can increase effects of what two drugs?
SUs Warfarin
40
Niacin
Vit B3
41
Monitoring for Niacin?
Check LFTs hepatotox warning
42
Risk of what at what dose for niacin?
Rhabdo \>=1 g/day
43
5 SEs of Niacin?
1. FLushing 2. Puritis itching 3. N/V/D 4. Incre BG 5. Hyperuracemia or gout
44
What Niacin formulation has less flushing and less hepato
Niaspan
45
Controlled and sustained release naicin?
Has decreased flushing but increase hepatotox
46
IR niacin has what
Poor tolerability due to flushing
47
When is fish oil recommended?
Adjuct to diet when TGs\>=500
48
What is special with Lovaza?
Increase LDL up to 44%
49
Fish oil interactioN?
Can increase bleeding time monitor INR if taken with warfarin
50
Repatha?
Evolocumab
51
When should you take Zocor and fluvastatin IR?
In the evening
52
How to take lovastatin?
with evening meal
53
When to take Altoprev?
at bedtime
54

NAPLEX (64 decks)

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