Rh Flashcards
most important antigen in Rh system
Rho/D
most important antibody in Rh system
anti-D
Rh positive frequency
85%
Rh negative frequency
15%
frequency of Rh negative people who will make anti-D if exposed to D antigen
50-75%
most immunogenic Rh antigen
D > c > E
Fisher Race theory
3 genes closely linked on chromosome give rise to 5 antigens with each gene resulting in one antigenic determinant site with no crossing over
genes inherited as one group of 3
D, C, c, E, e
Wiener theory
1 gene gives rise to 3 antigenic sites (5 antigens)
1 gene gives rise to antigens responsible for numerous blood factors on red cells
R, r, Rh, hr
Fisher Race nomenclature
D, C, c, E, e
Wiener nomenclature
R, r, Rh, hr
Tippett theory
2 genes (RHD and RHCE) give rise to major Rh antigens variations in RHCE genes give rise to C, E, c, e antigens
Rosenfield terminology
Rh1, Rh2, Rh3, Rh3, Rh4, Rh5, Rh12, Rh7, Rh22
Rh1
D
Rh2
C
Rh3
E
Rh4
little c
Rh5
little e
Rh12
G
Rh7
Ce
Rh22
CE
Rh32
low frequency found primarily in black population, associated with weak C, e
2 Rh genes
RHD
RHCE
serine at position 103 RHD
D protein
serine at position 103 RHCE
big C
proline at position 103 RHCE
little c
proline at position 226 RHCE
big E
alanine at position 226 RHCE
little e
RHAG gene
co-expressor required to be present in order for Rh antigens to successfully express
Weiner frequencies in white population
R1 > r > R2 > R0
Weiner frequencies in black population
R0 > r > R1 > R2
Weiner frequencies in asian population
R1 > R2 > r > R0