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CCHS SBB > Duffy and Kidd > Flashcards

Duffy and Kidd Flashcards

1
Q

Duffy system chromosome

A

1

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2
Q

gene responsible for FY antigen

A

ACKr1 (atypical chemokine receptor 1)

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3
Q

Fya amino acid

A

glycine

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4
Q

Fyb amino acid

A

asparagine

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5
Q

Duffy antigens on cord cells?

A

yes

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6
Q

effect of ficin and papain on Fya and Fyb antigens

A

destroyed

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7
Q

effect of thiol reagents on Fya and Fyb antigens

A

not affected

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8
Q

Duffy antigen present when Fya or Fyb present

A

Fy3, Fy5, Fy6

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9
Q

effect of enzymes, pronase, DTT, acid on Fy3

A

resistant

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10
Q

Duffy antigen that requires normal Rh for expression

A

Fy5

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11
Q

Duffy antigen not expressed on Rh null cells

A

Fy5

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12
Q

effect of enzymes, pronase, DTT, acid on Fy5

A

resistant

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13
Q

cells negative to which Duffy antigen are resistant to P. knowlesi and P. vivax but not P. falciparum?

A

Fy6

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14
Q

effect on ficin/papain, pronase on Fy6

A

destroyed

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15
Q

effect of trypsin, DTT, acid on Fy6

A

resistant

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16
Q

gene mutation where Duffy antigens are not expressed on red cells but are expressed on tissues

A

Fy(a-b-)

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17
Q

Duffy phenotype that provides resistance to P. vivax and P. knowlesi

A

Fy(a-b-)

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18
Q

Duffy phenotype that can make anti-Fy5

A

Fy(a-b-)

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19
Q

does Fy(a-b-) phenotype make anti-Fya or anti-Fyb?

A

no

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20
Q

true null Duffy phenotype where Duffy antigens are not expressed on red cells or tissues

A

FyFy

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21
Q

can FyFy phenotype make anti-Fya and anti-Fyb?

A

yes

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22
Q

Fy(a+b-) phenotype frequency

A

20% white

10% black

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23
Q

Fy(a-b+) phenotype frequency

A

32% white

20% black

24
Q

Fy(a+b+) phenotype frequency

A

48% white

2% black

25
Q

Fy(a-b-) phenotype frequency

A

very rare white

68% black

26
Q

Duffy antibody class

A

IgG

27
Q

do Duffy antibodies bind complement?

A

no

28
Q

how much more common is anti-Fya than anti-Fyb?

A

20x

29
Q

Duffy antibody usually made secondary to other antibodies

A

anti-Fyb

30
Q

Duffy antibody found only in immunized Fy(a-b-) white individuals

A

anti-Fy3

31
Q

how to distinguish anti-Fy3 from combination anti-Fya anti-Fyb?

A

enzymes will not destroy reactions of anti-Fy3

32
Q

Duffy antibody found in blacks with Fy(a-b-) phenotype

A

anti-Fy5

33
Q

Kidd system gene

A

JK

34
Q

JK gene located on chromosome ___

A

18

35
Q

Kidd system antigens located on…

A

red blood cells and kidney tissue

36
Q

red cell antigens carried by human erythroid urea transport protein HUT11

A

Jka and Jkb

37
Q

antigens associated with urea transport mechanism

A

Kidd

38
Q

red cell antigens that reside as antigen clusters on red cell surface

A

Kidd

39
Q

Kidd antigens on cord cells?

A

yes

40
Q

effect of enzymes on Kidd antigens

A

enhanced

41
Q

effect of DTT, AET, chloroquinine diphosphate on Kidd antigens

A

resistant

42
Q

Jk(a+b-) phenotype frequency

A

28% white

57% black

43
Q

Jk(a-b+) phenotype frequency

A

23% white

9% black

44
Q

Jk(a+b+) phenotype frequency

A

49% white

34% black

45
Q

Jk(a-b-) phenotype frequency

A

rare in all populations

46
Q

Jka antigen frequency

A

77% white

91% black

47
Q

Jkb antigen frequency

A

73% white

43% black

48
Q

Jk3 antigen frequency

A

100%

49
Q

rare homozygous JkJk silent gene phenotype

A

true null Jk(a-b-)

50
Q

dominant inhibitor suppressor gene Kidd phenotype

A

In(Jk)

51
Q

test for Jk(a-b-) phenotype

A

2M urea lysis

52
Q

effect of 2M urea on Jk(a-b-) cells

A

resist lysis, shrink and shrivel

53
Q

effect of 2M urea on normal Kidd antigen cells

A

swell and lyse

54
Q

Kidd antibody class

A

IgG

55
Q

do Kidd antibodies bind complement?

A

yes

56
Q

IgG antibody that looks like inseparable anti-JkaJkb

A

anti-Jk3

57
Q

anti-Jk3 reacts with which cells?

A

all cells except Jk(a-b-)

CCHS SBB (40 decks)

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