Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

CCHS SBB > ABO/H/Secretor/Lewis > Flashcards

ABO/H/Secretor/Lewis Flashcards

1
Q

ABO antigens detected on embryos at ___ age

A

5-6 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

ABO antigens on chromosome __

A

9

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

H antigen substrate

A

fucose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

formation of A, B, and H antigens results from interactions of genes on 3 separate loci: __, __, ___

A

ABO, Hh, Se

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

H gene

A

FUT1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Secretor gene (Se)

A

FUT2

fuctosyltransferase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

H and Se genes located on chromosome ___

A

19

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

active secretor gene

A

Se

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

inactive secretor gene

A

se

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Se/se gene frequency

A

80% secretors (SeSe or Sese)

20% non-secretors (sese)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

inheritance of Se gene results in ____ added to ____ chains resulting in type 1 H antigen substances in secretions

A

fucose/type1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

inheritance of H gene results in ___ added to ____ chains resulting in type 2 H antigens on red blood cells

A

fucose/type 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

H gene transferase

A

alpha-2-L-fucosyltransferase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

A gene transferase

A

alpha-3-acetryl-galactosaminyl-transferase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

B gene transferase

A

alpha-3-D-galactosyltransferase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

O gene transferase

A

none; gene is non-functional

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

oligosaccharide chain linkage in secretions

A

beta 1-3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

oligosaccharide chain linkage on red cells

A

beta 1-4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

A1 subgroup frequency

A

80% of A population

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

A2 subgroup frequency

A

20% of A population

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

anti-A1 lectin

A

Dolichos biflorus

22
Q

expected reaction of A1 cells with Dolichos biflorus

A

positive

23
Q

Ax subgroup presentation

A

no reaction with anti-A
weak reaction with anti-A,B
may produce anti-A1

24
Q

Am subgroup presentation

A

no reactions with anti-A or anti-A,B

25
Q

Aend subgroup presentation

A

weak reactions with anti-A and anti-A,B

26
Q

Ael subgroup presentation

A

no reactions with anti-A or anti-A,B but eluates contain anti-A

27
Q

Ay subgroup presentation

A

no reactions with anti-A, anti-A1, or anti-A,B

28
Q

B3 subgroup presentation

A

+/mf anti-B
+/mf anti-A,B
no anti-B in serum
secretes H

29
Q

Bx subgroup presentation

A

0/+ anti-B
0/++ anti-A,B
no anti-B in serum
secretes B and H

30
Q

Bm subgroup presentation

A

+/++ anti-B
+/++ anti-A,B
anti-B in serum
secretes B and H

31
Q

arises from inheritance of nonfunctional FUT1 gene, recessive genotype hh, and nonfunctional Se gene

A

Bombay phenotype

32
Q

Bombay phenotype types as ___

A

O

33
Q

Bombay phenotype rare disease association

A

Leukocyte Adhesion Deficiency 2 (LAD2) – lack of fucose

34
Q

Bombay phenotype antibodies in serum

A

anti-A
anti-B
anti-H

35
Q

Bombay phenotype secretor status

A

non-secretor

36
Q

Para-Bombay secretor status

A

secretor

37
Q

Para-Bombay phenotype presentation

A

H-deficient secretors

homozygous for nonfunctional H gene but inherit at least 1 normal functional secretor gene

38
Q

para-Bombay phenotype serum reactions

A

anti-H and/or anti-IH

39
Q

lectin

A

plant seed extract that agglutinates human red cells with high degree of specificity

40
Q

anti-H lectin

A

Ulex europaeus

41
Q

isoagglutinins

A

term reserved for expected antibodies in ABO system

42
Q

alloantibodies

A

individual that has the antibody will not have the corresponding antigen

43
Q

ABO antibody type

A

IgM

44
Q

anti-A,B

A

formed by group O individuals and present in fairly high concentrations

45
Q

anti-A,B antibody class

A

IgG and IgM

46
Q

ABO antibody most likely in ABO HDN

A

anti-A,B

47
Q

anti-A,B HDN

A

group O moms make IgG anti-A,B when carrying group A or B baby

48
Q

autoantibody produced by group A1 and A1B

A

anti-H

49
Q

H antigen expression on blood types

A

O > Ax > A2 > B > A2B > A1 > A1B > Oh

50
Q

blood group with most H antigen expression

A

O

51
Q

(normal) blood group with least H antigen expression

A

A1B

CCHS SBB (40 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions