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CCHS SBB > Immune Disorders > Flashcards

Immune Disorders Flashcards

1
Q

3 major classifications of immune disorders

A

Exaggerated
Diminished
Loss of self-recognition/autoimmunity

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2
Q

Types of exaggerated immune disorders

A

Hypersensitivity

Hypergammaglobulinemia

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3
Q

Heightened state of immune response; enhanced immune reaction to an antigen. Normal response but uncontrolled that results in inflammation and possible tissue damage

A

Hypersensitivity

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4
Q

Type 1 hypersensitivity examples

A

Allergic

Anaphylactic

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5
Q

Antibody class implicated in type 1 hypersensitivity

A

IgE, IgA

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6
Q

Type 1 hypersensitivity reaction in blood bank

A

IgA antibody

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7
Q

Type 2 cytotoxic hypersensitivity examples

A

cold auto, warm auto, transfusion reaction, HDFN

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8
Q

Antibody class implicated in type 2 cytotoxic hypersensitivity

A

IgG, IgM

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9
Q

Hypersensitivity in which antigen-antibody reaction activates complement resulting in cell death due to lysis

A

Type 2 cytotoxic

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10
Q

Antibody implicated in type 3 immune complex hypersensitivity

A

IgG, IgM

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11
Q

Hypersensitivity in which IgG or IgM antibody attaches to antigen and forms immune complex, which is deposited in extra vascular tissues and infiltrated by neutrophils causing local tissue damage

A

Type 3 immune complex

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12
Q

Examples of type 3 immune complex hypersensitivity

A

Serum sickness, Arthus reaction

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13
Q

Hypersensitivity in which CD4 T lymphs react with foreign antigens and release lymphokines that attract neutrophils, monocytes, and macrophages

A

Type 4 delayed

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14
Q

Hypersensitivity that promotes fibrin deposition, produces edema, enhances inflammatory response

A

Type 4 delayed

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15
Q

Examples of type 4 delayed hypersensitivity

A 
Hypersensitivity pneumonitis
Tuberculin-type hypersensitivity
Contact dermatitis
GVHD
Allograft rejection
Poison ivy
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16
Q

Type(s) of hypersensitivity that are humoral mediated

A

1, 2, 3

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17
Q

Type(s) of hypersensitivity that are cell mediated

A

4

18
Q

Excessive production of antibodies

A

Hypergammaglobulinemia

19
Q

Myeloproliferative disorder characterized by increased or unregulated increased production of immunoglobulins

A

Hypergammaglobulinemia

20
Q

Affecting one class or antibody or one part of the antibody

A

Monoclonal

21
Q

Antibody class implicated in multiple myeloma

A

Usually IgG, rarely IgA

22
Q

Malignancy of mature plasma cells that results in monoclonal increase in antibody component with IgG being most common

A

Multiple myeloma

23
Q

Most serious and common plasma cell disease

A

Multiple myeloma

24
Q

Examples of Hypergammaglobulinemia

A

Multiple myeloma

Waldenstrom’s macroglobulinemia

25
Q

Antibody class implicated in Waldenstrom’s macroglobulinemia

A

IgM

26
Q

Affecting more than one class of antibody

A

Polyclonal

27
Q

Examples of diminished category of immune disorders

A

Immunodeficiency

28
Q

Immune disorder in which immune system fails to mount immune response

A

Diminished

29
Q

Immune disorder type that results in secondary opportunistic infections

A

Immunodeficiency

30
Q

Examples of congenital immunodeficiency

A

Bruton’s agammaglobulinemia
DiGeorge syndrome
IgA deficiency

31
Q

Congenital Immunodeficiency in which B cells are absent or markedly reduced and don’t mature into normal cells, resulting in little or no IgG production

A

Bruton’s agammaglobulinemia

32
Q

Congenital Immunodeficiency due to reduced T cells

A

DiGeorge syndrome

33
Q

Most common congenital immunodeficiency

A

IgA deficiency

34
Q

Acquired immunodeficiency examples

A

HIV/AIDS

Hodgkin’s disease

35
Q

Immune disorder classification I which there is loss or breakdown of self-tolerance resulting in auto-reactive antibodies

A

Loss of self-recognition/autoimmunity

36
Q

Types of autoimmunity immune disorders

A

Systemic

Organ specific

37
Q

Examples of systemic autoimmunity

A

Lupus

Rheumatoid arthritis

38
Q

Examples of organ specific autoimmunity

A

Graves’ disease
Goodpasture’s syndrome
Diabetes mellitus

39
Q

Electrical positive and negative charges between individual red cells that keep them apart

A

Zeta potential

40
Q

Causes of rouleaux

A

High level of immunoglobulin proteins

Elevated fibrinogen

CCHS SBB (40 decks)

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