Immune Disorders

Question 1

3 major classifications of immune disorders

Answer 1

Exaggerated
Diminished
Loss of self-recognition/autoimmunity

Question 2

Types of exaggerated immune disorders

Answer 2

Hypersensitivity

Hypergammaglobulinemia

Question 3

Heightened state of immune response; enhanced immune reaction to an antigen. Normal response but uncontrolled that results in inflammation and possible tissue damage

Answer 3

Hypersensitivity

Question 4

Type 1 hypersensitivity examples

Answer 4

Allergic

Anaphylactic

Question 5

Antibody class implicated in type 1 hypersensitivity

Answer 5

IgE, IgA

Question 6

Type 1 hypersensitivity reaction in blood bank

Answer 6

IgA antibody

Question 7

Type 2 cytotoxic hypersensitivity examples

Answer 7

cold auto, warm auto, transfusion reaction, HDFN

Question 8

Antibody class implicated in type 2 cytotoxic hypersensitivity

Answer 8

IgG, IgM

Question 9

Hypersensitivity in which antigen-antibody reaction activates complement resulting in cell death due to lysis

Answer 9

Type 2 cytotoxic

Question 10

Antibody implicated in type 3 immune complex hypersensitivity

Answer 10

IgG, IgM

Question 11

Hypersensitivity in which IgG or IgM antibody attaches to antigen and forms immune complex, which is deposited in extra vascular tissues and infiltrated by neutrophils causing local tissue damage

Answer 11

Type 3 immune complex

Question 12

Examples of type 3 immune complex hypersensitivity

Answer 12

Serum sickness, Arthus reaction

Question 13

Hypersensitivity in which CD4 T lymphs react with foreign antigens and release lymphokines that attract neutrophils, monocytes, and macrophages

Answer 13

Type 4 delayed

Question 14

Hypersensitivity that promotes fibrin deposition, produces edema, enhances inflammatory response

Answer 14

Type 4 delayed

Question 15

Examples of type 4 delayed hypersensitivity

Answer 15

Hypersensitivity pneumonitis
Tuberculin-type hypersensitivity
Contact dermatitis
GVHD
Allograft rejection
Poison ivy

Question 16

Type(s) of hypersensitivity that are humoral mediated

Answer 16

1, 2, 3

Question 17

Type(s) of hypersensitivity that are cell mediated

Answer 17

4

Question 18

Excessive production of antibodies

Answer 18

Hypergammaglobulinemia

Question 19

Myeloproliferative disorder characterized by increased or unregulated increased production of immunoglobulins

Answer 19

Hypergammaglobulinemia

Question 20

Affecting one class or antibody or one part of the antibody

Answer 20

Monoclonal

Question 21

Antibody class implicated in multiple myeloma

Answer 21

Usually IgG, rarely IgA

Question 22

Malignancy of mature plasma cells that results in monoclonal increase in antibody component with IgG being most common

Answer 22

Multiple myeloma

Question 23

Most serious and common plasma cell disease

Answer 23

Multiple myeloma

Question 24

Examples of Hypergammaglobulinemia

Answer 24

Multiple myeloma

Waldenstrom’s macroglobulinemia

Question 25

Antibody class implicated in Waldenstrom’s macroglobulinemia

Answer 25

IgM

Question 26

Affecting more than one class of antibody

Answer 26

Polyclonal

Question 27

Examples of diminished category of immune disorders

Answer 27

Immunodeficiency

Question 28

Immune disorder in which immune system fails to mount immune response

Answer 28

Diminished

Question 29

Immune disorder type that results in secondary opportunistic infections

Answer 29

Immunodeficiency

Question 30

Examples of congenital immunodeficiency

Answer 30

Bruton’s agammaglobulinemia DiGeorge syndrome IgA deficiency

Question 31

Congenital Immunodeficiency in which B cells are absent or markedly reduced and don’t mature into normal cells, resulting in little or no IgG production

Answer 31

Bruton’s agammaglobulinemia

Question 32

Congenital Immunodeficiency due to reduced T cells

Answer 32

DiGeorge syndrome

Question 33

Most common congenital immunodeficiency

Answer 33

IgA deficiency

Question 34

Acquired immunodeficiency examples

Answer 34

HIV/AIDS | Hodgkin’s disease

Question 35

Immune disorder classification I which there is loss or breakdown of self-tolerance resulting in auto-reactive antibodies

Answer 35

Loss of self-recognition/autoimmunity

Question 36

Types of autoimmunity immune disorders

Answer 36

Systemic | Organ specific

Question 37

Examples of systemic autoimmunity

Answer 37

Lupus | Rheumatoid arthritis

Question 38

Examples of organ specific autoimmunity

Answer 38

Graves’ disease Goodpasture’s syndrome Diabetes mellitus

Question 39

Electrical positive and negative charges between individual red cells that keep them apart

Answer 39

Zeta potential

Question 40

Causes of rouleaux

Answer 40

High level of immunoglobulin proteins | Elevated fibrinogen