Blood Pathophysiology Flashcards
percent of blood made up of plasma
55%
percent of blood made up of RBC
45%
percent of blood made up of WBC and platelets
<1%
percent of plasma made up of albumin
55%
percent of plasma made up of globulins
38%
percent of plasma made up of fibrinogen
7%
percent of plasma made up of clotting factors
<1%
function of albumimn
maintain colloid osmotic balance
where is albumin produced
hepatocytes of liver
where are globulins produced
hepatocytes and plasma cells
function of globulins
participate in immune system
where is fibrinogen produced
hepatocytes of liver
function of fibrinogen
blood coagulation and inflammation management
function of clotting factors
convert fibrinogen into fibrin for clotting
what regulates differentiation and proliferation of HPCs?
cytokines (growth factors, interleukins)
where does hematopoiesis occur at 3 months in-utero?
liver
at what embryotic age does hematopoiesis start to include white cells and platelets?
3 months
where is early hematopoiesis in utero?
yolk sac
where does hematopoiesis occur from 3-6 months in utero?
spleen
where does hematopoiesis occur after 6 months in utero?
bone marrow
site of T cell differentiation
thymus
site of B cell production
lymph nodes
site of hematopoiesis in infants and children
bone cavities (flat bones, skull, sternum, ribs, pelvis, long bones)
what is the site of hematopoiesis in adults?
flat and long bones
