Other Blood Groups Flashcards
1
Q
Diego system chromosome
A
17
2
Q
red cell membrane anion exchanger
A
band 3
3
Q
what antigens are located on Band 3, red cell membrane anion exchanger?
A
Diego
4
Q
Diego antibodies are what antibody class?
A
IgG
5
Q
does anti-Dia cause HDFN?
A
yes
6
Q
does anti-Dia bind complement?
A
yes
7
Q
Diego A is a ___ frequency antigen
A
low
8
Q
Diego B is a ___ frequency antigen
A
high
9
Q
does anti-Dib cause HDFN?
A
yes
10
Q
Wright A is a ___ frequency antigen
A
low
11
Q
Wright B is a ___ frequency antigen
A
high
12
Q
does anti-Wra cause HDFN?
A
yes
13
Q
Wright antibodies are what antibody class?
A
IgG
14
Q
which Wright antibody is a common autoantibody?
A
anti-Wrb
15
Q
effect of enzymes on Diego system antigens
A
resistant
16
Q
Yt system is on chromosome ___
A
7
17
Q
previous name for Yt antigens
A
Cartwright
18
Q
where are Yt system antigens located
A
AChE (achetylcholeinsterase)
19
Q
which Yt antigen is high frequency
A
Yta
20
Q
which Yt antigen is low frequency
A
Ytb
21
Q
effect of ficin, papain, DTT, pronase on Yt antigens
A
destroyed
22
Q
effect of trypsin and acid on Yt antigens
A
resistant
23
Q
Yt(a+b-) phenotype frequency
A
92% all populations
24
Q
Yt(a-b+) phenotype frequency
A
rare
25
Yt(a+b+) phenotype frequency
7% all populations
26
Yt antibody class
IgG
27
are Yt antibodies clinically significant
no
28
which Yt antibody has caused rare incidence of acute and delayed HTR
anti-Yta
29
Xg blood group antigen
Xga
30
Xg antigen on chromosome ___
X
31
Xga phenotype frequency
89% females
| 66% males
32
Xg antigen expression on cord cells?
weak
33
effect of ficin and papain on Xg antigens
destroyed
34
effect of DTT on Xg antigens
resistant
35
which "other" blood group antigen is a useful genetic marker
Xg
36
Xga antibody class
IgG
37
which "other" blood group system antigen may appear as mixed field due to low density of antigen sites
anti-Xga
38
does anti-Xga cause HTR or HDFN?
no
39
which blood group antigen system is found on erythrocyte membrane-associated protein
Scianna
40
low frequency Scianna antigens
Sc2 and Sc4
41
high frequency Scianna antigens
Sc1 and Sc3
42
effect of enzymes on Scianna antigens
resistant
43
Scianna null phenotype
Sc:1-2-3-
44
what population is Scianna null phenotype seen in?
Marshall Islands, Papua New Guinea
45
Scianna antibody class
IgG
46
are Scianna antigens clinically significant
no
47
what antibody is produced by people with rare Scianna null phenotype
anti-Sc3
48
Dombrock antigens
```
Doa
Dob
Gya
Hy
Joa
```
49
are Dombrock antigens high or low frequency
high
50
effect of enzymes on Dombrock antigens
resistant
51
Dombrock antibody class
IgG
52
are Dombrock antibodies clinically significant?
yes
53
can Dombrock antibodies cause HDFN?
yes
54
what population develops anti-Gya
Dombrock null phenotype
55
where are Colton system antigens found
aquaphorin-1, water transporter
56
which Colton antigen is high frequency
Coa
57
which Colton antigen is low frequency
Cob
58
antigen frequency of Co3
100% all populations
59
Colton antibody class
IgG
60
do Colton antibodies cause HDFN
yes
61
what cells do anti-Co3 react with
all red cells except rare Colton null phenotype
62
Colton antigens are found on what body parts
blood cells and kidneys
63
which LW system antigen is high frequency
LWa
64
which LW system antigen is low frequency
LWb
65
LW(a+b-) phenotype frequency
97% all populations
66
LW(a-b+) phenotype frequency
rare all populations
67
LW(a+b+) phenotype frequency
3% most populations
| 6% Finns
68
anti-LWa may be mistaken for which antibody?
anti-D
69
autoanti-LW common in what disease association?
warm autoimmune hemolytic anemia
70
what effect does D negative antigen status have on LW expression?
D neg adults = decreased LW expression
71
is LW expressed on cord cells?
yes
72
where do Gerbich system antigens reside
GPC and GPD structures
73
Yus phenotype:
Ge:-2, 3, 4
74
Gerbich phenotype:
Ge:-2,-3,4
75
Leach phenotype:
Ge:-2,-3,-4
76
what is Gerbich null phenotype
Leach phenotype Ge:-2,-3.-4
77
what causes Gerbich null phenotype?Kell
deficiency in GPC and GPD
78
what antigen expression is affected by Gerbich nul phenotype?
Kell
79
Gerbich antibody class
IgG, few IgM
80
are Gerbich antibodies clinically significant
no
81
Cromer system chromosome
1
82
Cromer system antigens located on:
complement regulator protein
83
effect of ficin, papain, glycine-acid EDT on Cromer antigens
resistant
84
effect of DTT treatment on Cromer antigens
weakened
85
effect of alpha chymotrypsin on Cromer antigens
destroyed
86
null Cromer phenotype
Inab
87
Cromer antigens expressed on what cells?
RBCs, WBCs, platelets
88
Cromer antibody class
IgG
89
are Cromer antibodies clinically significant
no
90
what inhibits Cromer antibodies?
serum or concentrated urine
91
how are Cromer antibodies removed from serum?
platelet concentrates
92
what antibody is made by Cromer null phenotype?
anti-IFC
93
which Indian antigen is low frequency?
Ina
94
which Indian antibody is high frequency?
Inb
95
what antigens function as lymphocyte homing receptors?
Indian
96
what antigens function as CD44 adhesion molecules?
Indian
97
what antigen is microbial receptor for polio virus?
Indian
98
Indian antibody class
IgM
99
are Indian antibodies clinically significant?
no
100
Vel antibody class
IgM
101
is Vel expressed on cord cells
weakly
102
does anti-Vel cause HTR
ues
103
what cell is AnWj expressed o?
Lu(a-b-)
104
what antigen is a microbial receptor for Haemophilus influenzae?
AnWj
105
what antigens are part of 901 high incidence series
Vel
AnWj
Sda
106
what antibody demonstrates with refractile mixed-field agglutination at AHG?
anti-Sda
107
how is anti-Sda neutralized
urine from Sda positive individuals
108
is Sda present on cord cells?
no
109
does Sda cause HTR
no
110
why can anti-Sda be seen in Sda positive prenatal patients
antigen suppression during pregnancy
111
where are HLA antigens found
all nucleated cells
112
what are HLA antigens on red cells sometimes called?
Bennett-Goodspeed (Bg)
113
what HLA class are Bg antigens
HLA class I
114
Bga is what HLA antigen
HLA-B7
115
Bgb is what HLA antigen
HLA-B17 (B57 or B58)
116
Hbc is what HLA antigen
HLA-A28 (A68 or A69)
117
how can HLA antigens be removed from red cells
chloroquine or EDTA/glycine-HCl
118
what effect do enzymes, AET, and DTT have on HLA antigens
resistant
119
are HLA antibodies clinically significant
no in transfusion, yes in transplant and platelet refractoriness
120
in what blood bank practice are HLA antibodies imporant
platelet refractoriness
121
what does low avidity mean in HTLA
affinity of antibody to antigen
122
what titer characteristic identifies HTLA antibodies
weak reactions with undiluted serum with titrations showing same weak reactions out to high dilutions
123
HTLA antibody class
IgG
124
list "HTLA" antibodies
```
Chido (Cha)
Rodgers (Rga)
Knops (Kna)
McCoy (McCa)
SIa
York (Yka)
Cost-Sterling (Csa)
John-Milton-Hagen (JMH)
```
125
are Chido/Rodgers system antigens high or low frequency
high
126
antigens found on 4th component (C4d) molecule of complement
Chido/Rodgers
127
are Chido/Rodgers antigens present on cord cells?
weak or absent
128
effect of enzymes on Chido/Rodgers antigens
destroyed
129
effect of DTT on Chido/Rodgers antigens
resistant
130
inhibition of anti-Ch1 and anti-Rg1
soluble plasma antigen or complement found in fresh human serum
131
what enhances Chido/Rodgers antibody reactivity?
testing against C4d-coated red cells
132
Knops system chromosome
1
133
antigens in Knops system
Kna (Knops)
McCa (McCoy)
SIa
Yka (York)
134
what antigen group is found on complement-regulatory glycoprotein complement receptor-1 (CR-1)
Knops
135
antigen system depressed in lupus, AIDS, malignancies
Knops
136
effect of papain and ficin on Knops antigens
weakened
137
effect of trypsin on Knops antigens
trypsin
138
which Knops antibody is more common in black populations
anti-McCa
139
which Knops antibody is more common in white populations
anti-Kna
140
is JMH antigen high or low frequency
high
141
effect of enzymes and DTT on JMH
destroyed
142
is JMH expressed on cord cells
weakly or no
143
JMH antibody class
IgG
144
is anti-JMH clinically significant
no
145
auto-anti-JMH often found in what patient population
elderly
146
Cost system serologically like what other blood group system
Knops
147
high frequency antigen of Cost system
Csa
148
effect of enzymes on Cost antigen
resistant
149
Cost antibody class
IgG
150
is anti-Csa clinically significant
no
151
Cost null phenotype
Cs(a-b-) Kn(a-b-) McC(a-) SI(a-) Yk(a-)
