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CCHS SBB > Lewis > Flashcards

Lewis Flashcards

1
Q

Se gene

A

fuctosyltransferase (FUT2)

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2
Q

Se gene necessary for ___ to be formed

A

Leb substance

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3
Q

LE (FUT3) gene

A

produces Lea substance in secretions

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4
Q

Lewis antigens

A

not truly antigens; plasma substances that absorb on to RBCs

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5
Q

Lewis gene chromosome

A

19

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6
Q

Se gene has genetic control on the ___ gene

A

Le

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7
Q

__ and __ genes must be inherited for Leb antigen to be produced

A

Le/Se

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8
Q

Le + H + Se = ___

A

Lea

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9
Q

presence of ___ results in conversion of some Lea plasma substance in to Leb plasma substance

A

Se gene

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10
Q

Lewis antigen characteristics

A

not on cord cells
diminished during pregnancy
found in secretions
found on red cells, lymphs, platelets, organ tissues
resistant to ficin, papain, DTT, glycine acid EDTA

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11
Q

Le(a+b-) secretor status and genes present

A

Le gene but not Se gene; non-secretor

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12
Q

Le(a-b+)

A

have Le and Se genes; secretors; Lea substance in plasma and saliva

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13
Q

Le(a-b-)

A

lele, more common in black population

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14
Q

Le(a+b+)

A

rarely exists in Asian ancestry

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15
Q

Lewis phenotype at birth

A

Le(a-b-) regardless of Le gene status because antigens are not developed

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16
Q

receptor for H. pylori in gastric mucosal epithelium

A

Leb antigen

17
Q

Lewis antibodies

A

IgM, naturally occuring

18
Q

Lewis antibodies clinical significance

A

insignificant

19
Q

Lewis antibodies HDN

A

no

20
Q

Lewis antibodies trx rxn

A

no

21
Q

anti-Lebh

A

reacts with A2 and O cells that are Le(b+)

neutralized by saliva with H or Leb substance

22
Q

Anti-LebL

A

reacts with all Le(b+) cells regardless of ABO type

23
Q

anti-Leab

A

reacts with all red cells except Le(a-b-); pattern for anti-Lea and anti-Leb combined

24
Q

anti-ALeB

A

reacts with A cells that are Le(b+)

25
Q

anti-BLeb

A

reacts with B cells that are Le(b+)

26
Q

substance used to determine individual’s secretor status

A

saliva

27
Q

studies to determine secretor status

A

inhibition/neutralization

28
Q

inhibition procedure

A

reagent anti-H lectin is incubated with individual’s heat-treated saliva; group O red cells added
H substance present in saliva will neutralize anti-H lectin and cells will not agglutinate–>secretor

29
Q

positive inhibition test

A

no agglutination

30
Q

meaning of positive inhibition test

A

secretor

31
Q

meaning of no agglutination in inhibition test

A

secretor

CCHS SBB (40 decks)

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