Lewis Flashcards
Se gene
fuctosyltransferase (FUT2)
Se gene necessary for ___ to be formed
Leb substance
LE (FUT3) gene
produces Lea substance in secretions
Lewis antigens
not truly antigens; plasma substances that absorb on to RBCs
Lewis gene chromosome
19
Se gene has genetic control on the ___ gene
Le
__ and __ genes must be inherited for Leb antigen to be produced
Le/Se
Le + H + Se = ___
Lea
presence of ___ results in conversion of some Lea plasma substance in to Leb plasma substance
Se gene
Lewis antigen characteristics
not on cord cells
diminished during pregnancy
found in secretions
found on red cells, lymphs, platelets, organ tissues
resistant to ficin, papain, DTT, glycine acid EDTA
Le(a+b-) secretor status and genes present
Le gene but not Se gene; non-secretor
Le(a-b+)
have Le and Se genes; secretors; Lea substance in plasma and saliva
Le(a-b-)
lele, more common in black population
Le(a+b+)
rarely exists in Asian ancestry
Lewis phenotype at birth
Le(a-b-) regardless of Le gene status because antigens are not developed
receptor for H. pylori in gastric mucosal epithelium
Leb antigen
Lewis antibodies
IgM, naturally occuring
Lewis antibodies clinical significance
insignificant
Lewis antibodies HDN
no
Lewis antibodies trx rxn
no
anti-Lebh
reacts with A2 and O cells that are Le(b+)
neutralized by saliva with H or Leb substance
Anti-LebL
reacts with all Le(b+) cells regardless of ABO type
anti-Leab
reacts with all red cells except Le(a-b-); pattern for anti-Lea and anti-Leb combined
anti-ALeB
reacts with A cells that are Le(b+)
