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CCHS SBB > Blood Components > Flashcards

Blood Components Flashcards

1
Q

transport temp of whole blood

A

1-10C

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2
Q

storage temp of whole blood

A

1-6C

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3
Q

expiration of CPDA whole blood

A

35 days

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4
Q

CPDA shelf life

A

35 days

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5
Q

CPDA with additive solution shelf life

A

42 days

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6
Q

open system packed cell expiration

A

24 hours

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7
Q

CPDA unit hematocrit requirement

A

<80%

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8
Q

additive solution unit hematocrit

A

~55-65%

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9
Q

indications for washed packed cells

A

history of allergic trx rxn

IgA deficiency with anti-IgA

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10
Q

washed RBC expiration

A

24 hours

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11
Q

indications for leukocyte reduced RBCs

A

febrile trx rxn due to HLA antibodies
immunosuppressed/immunodeficient
prevent production of HLA antibodies in chronic trx

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12
Q

irradiated RBC shelf life

A

28 days or original shelf life (whichever comes first)

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13
Q

why are irradiated red cells given a shortened expiration date?

A

irradiation weakens RBC membrane, gives unacceptable 24 hour red cell survival after 28 days and increases supernatant potassium

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14
Q

liquid red cell storage temp

A

1-6C

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15
Q

liquid red cell transport temp

A

1-10C

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16
Q

how long after collection are liquid red cells stored?

A

within 24 hours

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17
Q

effects of increased blood storage temperature

A

accelerates metabolism
enzymes become active
bacterial growth

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18
Q

effects of decreased blood storage temp

A

nutrients not utilized
danger of accidental freezing/crystal formation
cells rupture

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19
Q

red cell storage lesion changes

A 
dec plasma pH
dec 2,3-DPG
dec ATP
dec dextrose
dec nitric oxide
inc plasma Hgb
inc plasma potassium
inc plasma ammonia
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20
Q

storage conditions including preservative solutions must provide for survival of red cells so that there are at least ___% viable cells at 24 hours post-transfusion

A

75

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21
Q

storage temp of frozen red cells

A

-80C or lower, -65C max

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22
Q

what cryoprotective agent is used in frozen red cells?

A

glycerol

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23
Q

shelf life of frozen red cells

A

10 years

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24
Q

when after collection can red cells by frozen?

A

within 6 days or after rejuvenation

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25
Q

effect of rejuvenation on red cell units older than 6 days to be frozen

A

restore 2,3-DPG to near normal

restore ATP to normal or higher

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26
Q

shelf life of thawed frozen red cells

A

24 hours

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27
Q

why are red cells from sickle trait donors not frozen?

A

cannot be deglycerolized, unit forms into gel-mass and hemolyzes during declygerolization

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28
Q

indications for frozen/deglycerolized red cells

A

store blood of donors with rare types
store autologous RBCs
IgA deficient with anti-IgA
severe allergic reactions

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29
Q

if declygerolized units are unused, when an they be refrozen?

A

within 20 hours of original thaw

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30
Q

what standard applies to rejuvenation of red cells?

A

5.7.4.4

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31
Q

red cell rejuvenation solution contains?

A

pyruvate
inosine
adenine
phosphate

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32
Q

purpose of red cell rejuvenation

A

restore 2,3-DPG and ATP levels

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33
Q

when can CPD or CPDA-1 red cells be rejuvenated?

A

after 14 days of liquid storage or up to 3 days past expiration date

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34
Q

what can be done to the product after red cell rejuvenation?

A

washed and transfused within 24 hours

glycerolized and frozen

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35
Q

when can AS-1 cells be rejuvenated?

A

anytime before expiration date

36
Q

frozen storage expiration of rejuvenated, glycerolized AS-1 red cells

A

3 years

37
Q

whole blood storage temp until platelets are removed

A

20-24C

38
Q

centrifugation pattern for platelet preparation

A

light spin –> platelet rich plasma –> heavy spin, remove plasma

39
Q

pH requirement for platelets

A

> 6.2

40
Q

platelet rest time before storage

A

1 hour

41
Q

minimum platelets per individual donor unit

A

5.5x10^10

42
Q

platelet expiration if seal broken

A

4 hours

43
Q

closed platelet pool expiration

A

5 days

44
Q

open platelet pool expiration

A

4 hours

45
Q

platelet storage lesion

A

dec ATP
dec ADP
dec pH
dec platelet glycoprotein

46
Q

composition of fresh frozen plasma

A

all coagulation factors, including labile V and VIII, antithrombin, ADAMTS13

47
Q

plasma frozen within ___ of whole blood collection

A

8 hours

48
Q

FFP storage

A

<18C or colder

49
Q

FFP transport media

A

dry ice

50
Q

FFP frozen expiration

A

1 year

51
Q

thawed FF expiration

A

24 hours (can be 5 days)

52
Q

FFP expiration with broken seal

A

24 hours

53
Q

what defines 24-hr plasma (PF24)

A

plasma frozen between 8-24 hours after collection

54
Q

24-hour plasma has reduced levels of?

A

factor V and VIII

55
Q

single donor plasma (liquid plasma)

A

plasma that has been separated from whole blood up to 5 days after whole blood expiration date

56
Q

factors present in cryo

A

fibrinogen
VIII
vWF
XIII

57
Q

main indication for cryo

A

fibrinogen replacement

58
Q

when is cryo prepared?

A

anytime during 1 year storage of FFP

59
Q

how is cryo prepared?

A

FFP placed in 1-6C and allowed to slowly thaw, precipitate forms –> cryo

60
Q

units VIII per cryo bag

A

80

61
Q

mg fibrinogen per cryo bag

A

150

62
Q

cryo storage

A

<18C, optimal -30C or colder

63
Q

frozen cryo expiration

A

1 year from original whole blood collection date

64
Q

thawed cryo expiration

A

6 hours

65
Q

thawed cryo storage temp

A

20-24C

66
Q

open pooled cryo expiration

A

4 hours

67
Q

indication for cryo-reduced plasma

A

TTP patients in plasma exchange therapy when non-responsive to albumin or FFP exchanges

68
Q

max red cell loss per week during apheresis

A

25 mL

69
Q

washed platelet shelf life

A

4 hours

70
Q

cryoprotective agent in frozen platelets

A

DMSO (dimethyl sulfoxide)

71
Q

shelf life of frozen platelets

A

2 years

72
Q

volume reduced platelet shelf life

A

4 hours (washed)

73
Q

donor Hct requirement for 2-unit red cell apheresis

A

> 40%

74
Q

2-unit red cell apheresis donation interval

A

16 weeks

75
Q

2-unit red cell apheresis male height/weight requirement

A

5ft1in

130 lb

76
Q

2-unit red cell apheresis female donor requirement

A

5ft5in

150 lb

77
Q

indication for plasma derived factor VIII

A

hemophilia A

78
Q

contraindication for recombinant FVIII

A

von Willebrand’s disease

79
Q

indication for factor XI

A

hemophilia B

hemophilia A with factor VIII inhibitors

80
Q

use of 5% albumin

A

hypovolemic shock, burn patients, therapeutic apheresis

81
Q

use of 25% albumin

A

cerebral edema

82
Q

advantage of albumin

A

remains intravascular, increases colloid osmotic pressure, rapidly expands volume, pulls fluid from interstitium

83
Q

temperature QC required on blood storage devices

A

must record continuously and be manually checked daily
manual reading every 4 hours is not continuous automated check
deviations recorded on chart with date and tech ID

84
Q

products transported at 1-10C on wet ice

A

whole blood
red cells
thawed or liquid plasma

85
Q

products transported frozen on dry ice

A

frozen red cells
frozen plasma
frozen cryo

86
Q

products transported at 20-24C

A

platelets
granulocytes
thawed or liquid cryo

CCHS SBB (40 decks)

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