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CCHS SBB > MNS/Lutheran/Kell/Kx > Flashcards

MNS/Lutheran/Kell/Kx Flashcards

1
Q

MNS system is on chromosome ___

A

4

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2
Q

M and N antigens located on what gene and glycoprotein?

A

GPYA

glycophorin A

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3
Q

U, S, s antigens located on what gene and glycoprotein?

A

GPYB

glycophorin B

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4
Q

what glycoproteins are used by Plasmodium falciparum as structures to enter red cells?

A

glycophorin A and glycophorin B

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5
Q

molecule that carries vast amounts of sialic acid that contributes to negative charge around red cell

A

glycophorin

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6
Q

enzyme effect on M and N antigens

A

destroyed due to cleavage of areas in amino acid chain

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7
Q

effect of chymotrypsin, DTT, and acid on M and N antigens

A

resistant

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8
Q

S and s expressed on cord cells?

A

yes

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9
Q

M and N expressed on cord cells?

A

yes

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10
Q

effect of chymotrypsin and pronase on S and s

A

destroyed

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11
Q

effect of trypsin, DTT, acid on S and s

A

resistant

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12
Q

MNS5 antigen

A

U

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13
Q

U expressed on cord cells?

A

yes

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14
Q

antigen frequency of U antigen

A

99% black

99.9% white

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15
Q

effect of enzymes on U

A

resistant

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16
Q

MNS system antigen carried on envelope of RBCs

A

En^a

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17
Q

effect of DTT and chymotrypsin on Ena

A

resistant

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18
Q

effect of ficin and trypsin on Ena

A

destroyed

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19
Q

MNS system antigen caused by silent mutation resulting in rearrangement of amino acids on GPA

A

Mg

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20
Q

MNS system antigen associated with weak U positive cells

A

Henshaw (He)

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21
Q

‘N’

A 
N like antigen carried on GPB
high prevalence (all cells except deficient of GPB)
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22
Q

MNS system antigen found in 7% of Chinese and 10% or greater in Thais

A

Mur

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23
Q

Mur is on which MNS system gene?

A

GPB

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24
Q

most common antibody seen after a-A and a-B in Chinese and Thai populations

A

anti-Mur

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25
Q

MNS system antigen on cells U- with weak expression of little s

A

Dantu

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26
Q

MNS system deletion or variant of GYPA resulting in no GPA, resulting in M-N- red cells

A

En(a-)

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27
Q

MNS system deletion of variant of GYPB resulting in no GPB

A

U negative

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28
Q

MNS deletion that provides protection against Plasmodium falciparum

A

U negative

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29
Q

MNS system true null phenotype

A

MkMk

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30
Q

MkMk null phenotype

A

M-N-En(a-)S-s-U-

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31
Q

MNS deletion phenotype with reduced levels of sialic acid on red cells

A

MkMk

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32
Q

anti-M antibody class

A

IgM

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33
Q

MN antibody that can sometimes be enhanced by lowering pH of serum to 6.5

A

anti-M

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34
Q

anti-M lectin

A

Iberis amara

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35
Q

anti-N antibody class

A

IgM

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36
Q

anti-N lectin

A

Vicia graminea

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37
Q

MN antibody historically seen in kidney dialysis patients due to residual formaldehyde

A

anti-Nf

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38
Q

anti-S antibody class

A

IgG

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39
Q

anti-s antibody class

A

IgG

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40
Q

anti-U antibody class

A

IgG

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41
Q

anti-U presentation on panels

A

combination of anti-S and anti-s

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42
Q

when is U antigen present?

A

if S or s is present

43
Q

Lutheran system chromosome

A

19

44
Q

are Lutheran antigens expressed on cord cells?

A

no

45
Q

effect of trypsin, AET/DTT on Lutheran antigens

A

destroyed

46
Q

effect of papain and ficin on Lutheran antigens

A

resistant or weakly affected

47
Q

Lua antigen frequency

A

8% white

5% black

48
Q

Lub antigen frequency

A

99.8%

49
Q

which Lutheran antigen is low prevalence?

A

Lua

50
Q

which Lutheran antigen is high prevalence?

A

Lub

51
Q

majority of individuals are what Lutheran phenotype?

A

Lu(a-b+)

52
Q

Lu3 antigen frequency

A

100%

53
Q

Auberger antigens are in which system?

A

Lutheran

54
Q

Aua antigen frequency

A

90%

55
Q

Aub antigen frequency

A

50% white

68% black

56
Q

autosomal amorphic recessive Lutheran phenotype

A

Lu null

57
Q

only Lutheran phenotype to produce anti-Lutheran antibody

A

Lu null

58
Q

autosomal dominant inhibitor gene Lutheran phenotype

A

In(Lu)

59
Q

marked suppression of production of all Lutheran system antigens

A

In(Lu)

60
Q

Lutheran phenotype that results in reduced expression of P1, I, AnWj, Indian, Knops, Cost, MER2

A

In(Lu)

61
Q

X-linked recessive suppressor gene Lutheran phenotype

A

Lu mod

62
Q

rare Lutheran phenotype carried on X chromosome

A

Lu mod

63
Q

anti-Lua antibody class

A

IgM

64
Q

Lutheran antibody that produces loose or stringy mixed-field agglutination

A

anti-Lua

65
Q

anti-Lub antibody class

A

IgG

66
Q

Lutheran antibody made by immunized individuals of rare recessive type Lu(a-b-)

A

anti-Lu3

67
Q

XK gene is on which chromosome?

A

X

68
Q

antigen of KX blood group system

A

Kx

69
Q

gene of Kx blood group system

A

XK

70
Q

antigen required for full expression of Kell system antigens

A

Kx

71
Q

precursor for Kell antigens

A

Kx

72
Q

KEL gene located on chromosome?

A

7

73
Q

Kell system antigens expressed on cord cells?

A

yes

74
Q

effect of DTT, ZZAP, 2-AET, EDTA/glycine-acid on Kell antigens

A

destroyed

75
Q

effect of enzymes on Kell system antigens

A

resistant

76
Q

___ gene encodes for Kell antigens inherited as a haplotype

A

KEL

77
Q

normal Kell haplotype

A

k, Kpb, Jsb

78
Q

number of mutations per Kell haplotype

A

one

79
Q

K antigen frequency

A

9% white
2% black
25% Arab

80
Q

k antigen frequency

A

> 99.9% all populations

81
Q

Kpa antigen frequency

A

2-3% white

never seen in other populations

82
Q

Kpb antigen frequency

A

99.9% all populations

83
Q

Jsa antigen frequency

A

20% black

low frequency in other populations

84
Q

Jsb antigen frequency

A

> 99.9%

85
Q

KEL1 antigen

A

K

86
Q

KEL2 antigen

A

k

87
Q

KEL3 antigen

A

Kpa

88
Q

KEL4 antigen

A

Kpb

89
Q

KEL6 antigen

A

Jsa

90
Q

KEL7 antigen

A

Jsb

91
Q

Kell system antigen expressed 100% in all populations on all red cells except K0 phenotype

A

Ku

92
Q

Kell system antigen expressed 100% in all populations on all red cells except McLeod phenotype and K0 phenotype

A

Km

93
Q

inheritance of homozygous silent gene K0 (K0K0)

A

Kell null

94
Q

Kell phenotype with weak expression of Kell antigens

A

Kmod

95
Q

Kell phenotype caused by lack of or mutation in XK gene, lack of Kx antigen

A

McLeod

96
Q

McLeod phenotype individuals make anti-___ when transfused

A

anti-KL

97
Q

physiologic condition associated with McLeod phenotype

A

X-linked chronic granulomatous disease

98
Q 
Kell phenotype:
no Kell antigens
no Ku
no Km
increased Kx
anti-Ku
A

Null (K0)

99
Q

Kell phenotype:
marked reduction in Kell antigens
increase in Kx
anti-Ku like antibody

A

Kmod

100
Q 
Kell phenotype:
reduction in Kell antigens but present
no Km
no Kx
anti-KL
A

McLeod CGD

101
Q 
Kell phenotype:
reduction in Kell antigens
no Km
no Kx
anti-Km
A

McLeod non-CGD

102
Q

Kell antibody class

A

IgG

103
Q

do Kell antibodies bind complement?

A

no

104
Q

3rd most potent antibody after ABO and Rh

A

Kell

CCHS SBB (40 decks)

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