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CCHS SBB > MNS/Lutheran/Kell/Kx > Flashcards

MNS/Lutheran/Kell/Kx Flashcards

1
Q

MNS system is on chromosome ___

A

4

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2
Q

M and N antigens located on what gene and glycoprotein?

A

GPYA

glycophorin A

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3
Q

U, S, s antigens located on what gene and glycoprotein?

A

GPYB

glycophorin B

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4
Q

what glycoproteins are used by Plasmodium falciparum as structures to enter red cells?

A

glycophorin A and glycophorin B

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5
Q

molecule that carries vast amounts of sialic acid that contributes to negative charge around red cell

A

glycophorin

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6
Q

enzyme effect on M and N antigens

A

destroyed due to cleavage of areas in amino acid chain

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7
Q

effect of chymotrypsin, DTT, and acid on M and N antigens

A

resistant

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8
Q

S and s expressed on cord cells?

A

yes

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9
Q

M and N expressed on cord cells?

A

yes

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10
Q

effect of chymotrypsin and pronase on S and s

A

destroyed

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11
Q

effect of trypsin, DTT, acid on S and s

A

resistant

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12
Q

MNS5 antigen

A

U

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13
Q

U expressed on cord cells?

A

yes

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14
Q

antigen frequency of U antigen

A

99% black

99.9% white

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15
Q

effect of enzymes on U

A

resistant

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16
Q

MNS system antigen carried on envelope of RBCs

A

En^a

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17
Q

effect of DTT and chymotrypsin on Ena

A

resistant

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18
Q

effect of ficin and trypsin on Ena

A

destroyed

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19
Q

MNS system antigen caused by silent mutation resulting in rearrangement of amino acids on GPA

A

Mg

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20
Q

MNS system antigen associated with weak U positive cells

A

Henshaw (He)

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21
Q

‘N’

A 
N like antigen carried on GPB
high prevalence (all cells except deficient of GPB)
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22
Q

MNS system antigen found in 7% of Chinese and 10% or greater in Thais

A

Mur

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23
Q

Mur is on which MNS system gene?

A

GPB

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24
Q

most common antibody seen after a-A and a-B in Chinese and Thai populations

A

anti-Mur

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25
MNS system antigen on cells U- with weak expression of little s
Dantu
26
MNS system deletion or variant of GYPA resulting in no GPA, resulting in M-N- red cells
En(a-)
27
MNS system deletion of variant of GYPB resulting in no GPB
U negative
28
MNS deletion that provides protection against Plasmodium falciparum
U negative
29
MNS system true null phenotype
MkMk
30
MkMk null phenotype
M-N-En(a-)S-s-U-
31
MNS deletion phenotype with reduced levels of sialic acid on red cells
MkMk
32
anti-M antibody class
IgM
33
MN antibody that can sometimes be enhanced by lowering pH of serum to 6.5
anti-M
34
anti-M lectin
Iberis amara
35
anti-N antibody class
IgM
36
anti-N lectin
Vicia graminea
37
MN antibody historically seen in kidney dialysis patients due to residual formaldehyde
anti-Nf
38
anti-S antibody class
IgG
39
anti-s antibody class
IgG
40
anti-U antibody class
IgG
41
anti-U presentation on panels
combination of anti-S and anti-s
42
when is U antigen present?
if S or s is present
43
Lutheran system chromosome
19
44
are Lutheran antigens expressed on cord cells?
no
45
effect of trypsin, AET/DTT on Lutheran antigens
destroyed
46
effect of papain and ficin on Lutheran antigens
resistant or weakly affected
47
Lua antigen frequency
8% white | 5% black
48
Lub antigen frequency
99.8%
49
which Lutheran antigen is low prevalence?
Lua
50
which Lutheran antigen is high prevalence?
Lub
51
majority of individuals are what Lutheran phenotype?
Lu(a-b+)
52
Lu3 antigen frequency
100%
53
Auberger antigens are in which system?
Lutheran
54
Aua antigen frequency
90%
55
Aub antigen frequency
50% white | 68% black
56
autosomal amorphic recessive Lutheran phenotype
Lu null
57
only Lutheran phenotype to produce anti-Lutheran antibody
Lu null
58
autosomal dominant inhibitor gene Lutheran phenotype
In(Lu)
59
marked suppression of production of all Lutheran system antigens
In(Lu)
60
Lutheran phenotype that results in reduced expression of P1, I, AnWj, Indian, Knops, Cost, MER2
In(Lu)
61
X-linked recessive suppressor gene Lutheran phenotype
Lu mod
62
rare Lutheran phenotype carried on X chromosome
Lu mod
63
anti-Lua antibody class
IgM
64
Lutheran antibody that produces loose or stringy mixed-field agglutination
anti-Lua
65
anti-Lub antibody class
IgG
66
Lutheran antibody made by immunized individuals of rare recessive type Lu(a-b-)
anti-Lu3
67
XK gene is on which chromosome?
X
68
antigen of KX blood group system
Kx
69
gene of Kx blood group system
XK
70
antigen required for full expression of Kell system antigens
Kx
71
precursor for Kell antigens
Kx
72
KEL gene located on chromosome?
7
73
Kell system antigens expressed on cord cells?
yes
74
effect of DTT, ZZAP, 2-AET, EDTA/glycine-acid on Kell antigens
destroyed
75
effect of enzymes on Kell system antigens
resistant
76
___ gene encodes for Kell antigens inherited as a haplotype
KEL
77
normal Kell haplotype
k, Kpb, Jsb
78
number of mutations per Kell haplotype
one
79
K antigen frequency
9% white 2% black 25% Arab
80
k antigen frequency
>99.9% all populations
81
Kpa antigen frequency
2-3% white | never seen in other populations
82
Kpb antigen frequency
99.9% all populations
83
Jsa antigen frequency
20% black | low frequency in other populations
84
Jsb antigen frequency
>99.9%
85
KEL1 antigen
K
86
KEL2 antigen
k
87
KEL3 antigen
Kpa
88
KEL4 antigen
Kpb
89
KEL6 antigen
Jsa
90
KEL7 antigen
Jsb
91
Kell system antigen expressed 100% in all populations on all red cells except K0 phenotype
Ku
92
Kell system antigen expressed 100% in all populations on all red cells except McLeod phenotype and K0 phenotype
Km
93
inheritance of homozygous silent gene K0 (K0K0)
Kell null
94
Kell phenotype with weak expression of Kell antigens
Kmod
95
Kell phenotype caused by lack of or mutation in XK gene, lack of Kx antigen
McLeod
96
McLeod phenotype individuals make anti-___ when transfused
anti-KL
97
physiologic condition associated with McLeod phenotype
X-linked chronic granulomatous disease
98
``` Kell phenotype: no Kell antigens no Ku no Km increased Kx anti-Ku ```
Null (K0)
99
Kell phenotype: marked reduction in Kell antigens increase in Kx anti-Ku like antibody
Kmod
100
``` Kell phenotype: reduction in Kell antigens but present no Km no Kx anti-KL ```
McLeod CGD
101
``` Kell phenotype: reduction in Kell antigens no Km no Kx anti-Km ```
McLeod non-CGD
102
Kell antibody class
IgG
103
do Kell antibodies bind complement?
no
104
3rd most potent antibody after ABO and Rh
Kell

CCHS SBB (40 decks)

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