Rest of NJCTL and Class Notes for Membranes & Proteins Section Flashcards
(cell signaling) cellular signaling is a part of a complex system of communication that governs basic … and coordinates …
cellular activities; cell actions
(cell signaling) the ability of cells to perceive and correctly respond to their microenvironment is the basis of …, …, and ….
development; tissue repair; immunity
(cell signaling) cells within multicellular organisms must communicate with one another to coordinate all aspects of life. single-celled organisms also communicate with one another to perform certain … tasks
symbiotic
(cell signaling) correct and appropriate signaling pathways are generally under …. and show shared evolution among organisms with ….
strong selective pressure; shared pathways
(signal transduction) transcription factors are … regulating the initiation of ….. They cause a cell to respond to a … in the … in a very specific way
cofactors; gene transcription; signal; environment
(signal transduction) this signal is anything that the cell has the ability to respond to. It could be …, a …, a …, …, etc
light; chemical; hormone; heat;
(signal transduction) a signal transduction pathway proceeds with reception of a …, transduction of that signal through the cell to the …, and finally results in …. of a ….
signal; DNA; expression; transcription factor
(signal transduction) the pathway starts when a new … (aka …) reaches a cell
signal; ligand
(signal transduction) external signal activates membrane-bound protein known as a …. These are like … in that they will bind with only 1 kind of substrate (signal)
receptor; enzymes
(signal transduction) the activated receptor triggers a cascade reaction, a …
metabolic pathway
(signal transduction) the metabolic pathway produces a specific …. in response to the signal. The product initiates … of a …
transcription factor; transcription; response gene
(signal transduction) transcription factors initiate the … of additional genes, which coordinate the cell’s …
transcription; response to stimuli
(regulation) when a receptor receives an external signal from another cell, the response can either be to … or … the … of a specific … within the ell
increase; decrease; concentration; molecule
(regulation) increasing the concentration is called … and decreasing production of that molecule isi called …
upregulation; downregulation
(regulation) example of up/downregulation: if no glucose is present but lactose is , bacteria would … glucose receptors and … lactose receptors
downregulate; upregulate
(regulation) during upregulation, the number of … on the surface of target cells …, making the cells more sensitive to a hormone or another agent
receptors; increase
(regulation) example of upregulation: there is an increase in uterine …. in the third trimester of pregnancy, promoting the contraction of the smooth muscle of the uterus
oxytocin receptors
(regulation) downregulation is a … in the number of … on the surface of target cells, making the cells less sensitive to a hormone or another agent. some receptors can be rapidly downregulated.
decrease; receptors
(regulation) example of downregulation: in type II diabetes –> characterized by elevated levels of insulin in the bloodstream but a loss of …. this downregulation can sometimes be reversed through exercise, and occasionally, a change in diet can also resolve the issue
insulin receptors
(single-celled signaling) in single-celled organisms, signal transduction pathways influence how the cells respond to its environment. many single-celled organisms live in … with other organisms, responding to signals released by adjacent cells
symbiotic relationships
(single-celled signaling) certain bacteria use … to communicate to other nearby cells and regulate specific …. in response to …. this is known as …
chemical messengers; reproductive pathways; population density; quorum sensing
(single-celled signaling) pseudomonas aeruginosa use quorum sensing to coordinate cell … they grow within a host without harming it until they reach a certain … once that is reached, they release a signal to aggressively … in order to overcome the host’s …. the bacteria create a … wherein they form a layer that completely covers the host’s … and then reproduce at an exponential rate. research has shown that garlic inhibits the formation of these layers by blocking the quorum sensing pathway. This is called ….
aggregation; concentration; replicate; immune system; biofilm; tissue; quorum inhibition
(multicellular signaling) multicellular organisms have physical pathways between adjacent cells to aid in … and ….
communication; transfer of substances
(multicellular signaling) in animal cells these cell junctions are:
tight junctions: can bind cells together into …
adhering junctions: fasten cells together into …. They are somewhat …
communication (gap) junctions: allow substances to …. from cell to cell. they are totally …. they are the equivalent of … in plants
leakproof sheets; strong sheets; leakproof; flow; leaky; plasmodesmata
(multicellular signaling) plant cells connect using … (… in ….) which are … that allow them to share …, …, and … via ….
plasmodesmata; openings; cell walls; channels; water; food; communicate; chemical messages
(multicellular signaling) animal and plant cells have different types of cell junctions mainly because plants have …. and animal cells do not
cell walls
(cell to cell communication) protein-based hormones: initiating … and …, …/ … on target (i.e. …)
complex; target; binding sites; receptors; glycoproteins
(cell to cell communication) lipid-based hormone: no specific …, in …, don’t have any …
target; membrane; one effect
(cell to cell communication) neurons are …. Neurotransmitters, … signals, are released by neuron A in a certain pattern. Neuron B receives them as a signal for a specific i…. Neuron A is the signaling neuron, neuron B acts as the …
specialized cells; protein; transduction pathway
(cell to cell communication) neurotransmitters are an example of …. communication between cells. in this type of communication, regular chemicals are released into the small space between the cells, a …. these regulators attach to receptors embedded in the … of nearby cells
short distance; synapse; plasma membrane
(cell to cell communication) synaptic signaling: cell-cell communication style; between …, not ….
neurons; long-distance
(cell to cell communication) photoreceptors in ... master pituitary (...): releases ... --> releasing ...
anterior; hormones; factors
(cell to cell communication) fight or flight molecule/hormone:
epinephrine
(cell to cell communication) epinephrine (… effect, but signal is not the same for all cells) released into the …, where it is sent throughout the body.
far-reaching; bloodstream
(cell to cell communication) cell response to epinephrine
hair follicle muscle cell- …, hair …
sweat gland muscle cell- …, …. is released
lung cells- …, take in more …
heart cells - …, more … to cells for …
liver cells- release …, to supply more … to cells
other responses as well
contract; stands up; contract; sweat; relax; air; speed up; oxygen; respiration; glucose; energy
(cell to cell communication) hormones are produced within certain organs of the body can travel long distances through the body to reach different … in many regions of the body.
Example: hormone testosterone is produced by … cells, and travels through the blood stream stimulating increases in …, …, and the development of ….
target cells; endocrine; muscle mass; bone growth; male secondary sex characteristics
(feedback) a feedback loop is the path that leads from the initial generation of a signal to the …. they are the … sequence in biology. can be either … or …
modification of an event; cause-and-effect; positive; negative
(feedback) a negative feedback loop happens when the outcome of an action acts to … of the original signal.
reverse cause
(feedback) most control systems in the body involve negative feedback systems. cells send signals to other cells to fix problems they sense. this could involve the release of another signal to … a problem, or more simply, the … of the original signal
examples:
… control
regulation of …
control of … levels
counteract; shut down; body temperature; pituitary hormones; blood glucose
(feedback) a positive feedback loop is one which involves cells continually … a signal until an outcome is reached. the key to positive feedback loops is that any small change will be …
amplifying; amplified
(feedback) positive feedback examples:
activities associated with childbirth offer two examples:
as contractions happen during labor, the hormone … is released into the bloodstream. as levels of this hormone increase, more … occur, until the baby is born which stops the feedback loop
lactation: the more a newborn baby suckles, the more …. this is due to a positive feedback loop involving the hormone …
oxytocin; contractions; milk is produced; prolactin
a metabolic pathway begins with a specific molecule and ends with a product. each step is catalyzed by a specific …
no .. = no …
enzyme; enzyme; reaction
(digestion) humans are … feeders
omnivorous bulk
(digestion) bulk feeders: ingesting
large things
(digestion) the human digestive tract is composed of …. it is regulated … by the … and the …
compartmentalized organs; hormonally; pancreas; brain
(digestion) cephalic phase- occurs before food enters the … and involves preparation of the body for … and … …, …, …and … of food stimulate the brain. …. are activated by … control
eating; digestion; sight; smell; taste; thought; salivary glands; neural
(digestion) amylase, an enzyme in saliva, hydrolyzes …, and glycogen into smaller …
starch; polysaccharides
(digestion) saliva combined with chewing (…) and movements of the pharynx and tongue turn the food into a …, a ball of …
mastication; bolus; partially digested food
(digestion) the bolus is passed into the …. from the mouth. smooth-muscle, wave-like contractions of the esophagus (…) move the bolus to the …. there the bolus is mixed into the digestive “soup” of the stomach. The stomach is …. and it churns the food into a ….. this is called the … phase
esophagus; peristalsis; stomach; muscular; homogenized acid chyme; gastric
(digestion) gastric phase: the stomach produces an enzyme that becomes active in the presence of acid. to avoid destruction of stomach cells, the active enzyme … is released into the … of the stomach as …. another cell releases … to make the lumen acidic. this activates the ….
pepsin; lumen; inactive pepsinogen; HCl; hydrolytic enzyme pepsin
(digestion) gastric phase: … cells produce pepsinogen, … cells produce HCl and all cells produce … to ensure a lining in the stomach that will protect the cells from the products they release. … breaks down proteins
chief; parietal; mucous; pepsin
(digestion) the pyloric sphincter is the transition from the gastric phase to the … phase. the major change that happens here is that … is ending and …. is beginning
intestinal; mechanical breakdown; absorption
(digestion) intestinal phase: the duodenum is the central processing area for …. the pancreas monitors the food entering the small intestine and releases … that engage …. The liver and gallbladder release … that help …, carbohydrates are given one last bath of …. and the brain is alerted to the influx of …
incoming food; hormones; multi organ responses; bile salts; absorb fats; hydrolytic enzymes; nutrients
(digestion) intestinal phase: the liver and gallbladder release bile salts that help absorb fats. the bile salts … (make …) the fat and make it possible for cells to …
emulsify; homogenized mixtures; absorb them
(digestion) intestinal phase: the pancreas releases enzymes that breakdown proteins, lipids, and carbs: " lipase- ... amylase- ... trypsin- ... chymotrypsin- ....
fats; carbs; proteins; proteins
(digestion) intestinal phase: finally, the mix of enzymes and food move through the intestines where nutrients are … and undigestible material is released via the ..
absorbed; anus
(digestion) as stated, the digestive system exhibits … control over other systems in the body. this is largely accomplished through communication with the …, …, and ….
hormonal; brain; pancreas; liver
(digestion) normal blood glucose level is …. per … of blood. this must be maintained for normal body function to proceed. when the pancreas recognizes an influx of glucose into the blood it releases…
90 mg; 100 mL; insulin
(digestion) insulin causes an … of sugar by the liver to … and … at the same time it suppresses … in the brain
uptake; store; convert to fat; hunger
(digestion) if the pancreas recognizes a situation where blood glucose will drop too low, it releases a hormone called … the effect is the opposite of insulin (… increases and … decreases)
glucagon; hunger; glucose uptake