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Pharmacology > Quiz 3: Anti-TB, Anti-fungal (Class/MOA) > Flashcards

Quiz 3: Anti-TB, Anti-fungal (Class/MOA) Flashcards

1
Q

Clotrimazole

A

Azole

Inhibits enzyme responsible for converting lanosterol to ergosterol

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2
Q

Fluconazole

A

Azole

Inhibits enzyme responsible for converting lanosterol to ergosterol

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3
Q

Itraconazole

A

Azole

Inhibits enzyme responsible for converting lanosterol to ergosterol

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4
Q

Ketoconazole

A

Azole

Inhibits enzyme responsible for converting lanosterol to ergosterol

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5
Q

Miconazole

A

Azole

Inhibits enzyme responsible for converting lanosterol to ergosterol

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6
Q

Posaconazole

A

Azole

Inhibits enzyme responsible for converting lanosterol to ergosterol

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7
Q

Voriconazole

A

Azole

Inhibits enzyme responsible for converting lanosterol to ergosterol

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8
Q

Anidulafungin

A

Echinocandins

Interferes with the synthesis of B-glucan

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9
Q

Caspofungin

A

Echinocandins

Interferes with the synthesis of B-glucan

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10
Q

Micafungin

A

Echinocandins

Interferes with the synthesis of B-glucan

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11
Q

Amphotericin B

A

Polyene Macrolides

binds to ergosterol in the plasma membrane and forms a pore.

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12
Q

Naftifin

A

Allylamines

Inhibits squalene epoxidasethat converts squalene to lanosterol

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13
Q

Terbinafine

A

Allylamines

Inhibits squalene epoxidasethat converts squalene to lanosterol

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14
Q

Tolnaftate

A

Allylamines

Inhibits squalene epoxidasethat converts squalene to lanosterol

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15
Q

Flucytosine

A

Enters fungal cell and disrupts DNA/protein synthesis

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16
Q

Isoniazid

A

Inhibits mycolic acid synthesis in cell wall

17
Q

Rifampin

A

Rifamycin

Interacts with bacterial RNA polymerase and blocks transcription

18
Q

Rifapentine

A

Rifamycin

Interacts with bacterial RNA polymerase but has longer half-life than rifampin

19
Q

Pyrazinamide

A

Lowers intracellular pH and inhibits growth

20
Q

Ethambutol

A

Interferes with cell wall synthesis (probably by inhibition of mycolic acid synthesis.

Pharmacology (34 decks)

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