Quiz 3: Anti-TB, Anti-fungal (Class/MOA) Flashcards
Clotrimazole
Azole
Inhibits enzyme responsible for converting lanosterol to ergosterol
Fluconazole
Azole
Inhibits enzyme responsible for converting lanosterol to ergosterol
Itraconazole
Azole
Inhibits enzyme responsible for converting lanosterol to ergosterol
Ketoconazole
Azole
Inhibits enzyme responsible for converting lanosterol to ergosterol
Miconazole
Azole
Inhibits enzyme responsible for converting lanosterol to ergosterol
Posaconazole
Azole
Inhibits enzyme responsible for converting lanosterol to ergosterol
Voriconazole
Azole
Inhibits enzyme responsible for converting lanosterol to ergosterol
Anidulafungin
Echinocandins
Interferes with the synthesis of B-glucan
Caspofungin
Echinocandins
Interferes with the synthesis of B-glucan
Micafungin
Echinocandins
Interferes with the synthesis of B-glucan
Amphotericin B
Polyene Macrolides
binds to ergosterol in the plasma membrane and forms a pore.
Naftifin
Allylamines
Inhibits squalene epoxidasethat converts squalene to lanosterol
Terbinafine
Allylamines
Inhibits squalene epoxidasethat converts squalene to lanosterol
Tolnaftate
Allylamines
Inhibits squalene epoxidasethat converts squalene to lanosterol
Flucytosine
Enters fungal cell and disrupts DNA/protein synthesis
Isoniazid
Inhibits mycolic acid synthesis in cell wall
Rifampin
Rifamycin
Interacts with bacterial RNA polymerase and blocks transcription
Rifapentine
Rifamycin
Interacts with bacterial RNA polymerase but has longer half-life than rifampin
Pyrazinamide
Lowers intracellular pH and inhibits growth
Ethambutol
Interferes with cell wall synthesis (probably by inhibition of mycolic acid synthesis.
