MOA: Treatment of Depression Flashcards
Selegiline
Monoamine Oxidase Inhibitors (MAOIs)
Inhibits metabolism/breakdown of NE, 5-HT, and dopamine
Tranylcypromine
Monoamine Oxidase Inhibitors (MAOIs)
Inhibits metabolism/breakdown of NE, 5-HT, and dopamine
Phenelzine
Monoamine Oxidase Inhibitors (MAOIs)
Inhibits metabolism/breakdown of NE, 5-HT, and dopamine
Amitriptyline
Tricyclic Antidepressants (TCAs)
Block reuptake of NE and 5-HT by inhibiting the transporter protein that brings them back into the nerve terminal
Nortriptyline
Tricyclic Antidepressants (TCAs)
Block reuptake of NE and 5-HT by inhibiting the transporter protein that brings them back into the nerve terminal
Desipramine
Tricyclic Antidepressants (TCAs)
Block reuptake of NE and 5-HT by inhibiting the transporter protein that brings them back into the nerve terminal
Imipramine
Tricyclic Antidepressants (TCAs)
Block reuptake of NE and 5-HT by inhibiting the transporter protein that brings them back into the nerve terminal
Citalopram
Selective Serotonin Reuptake Inhibitors (SSRIs)
Block reuptake of 5-HT
Escitalopram
Selective Serotonin Reuptake Inhibitors (SSRIs)
Block reuptake of 5-HT
Fluoxetine
Selective Serotonin Reuptake Inhibitors (SSRIs)
Block reuptake of 5-HT
Paroxetine
Selective Serotonin Reuptake Inhibitors (SSRIs)
Block reuptake of 5-HT
Sertraline
Selective Serotonin Reuptake Inhibitors (SSRIs)
Block reuptake of 5-HT
Duloxetine
Serotonin/Norepinephrine Reuptake Inhibitors (SNRIs)
Block reuptake of NE and 5-HT
Venlafaxine
Serotonin/Norepinephrine Reuptake Inhibitors (SNRIs)
Block reuptake of NE and 5-HT
Buproprion
Weak dopamine and NE reuptake inhibitor
Mirtazipine
Enhances serotonin and NE neurotransmission by blocking presynaptic a2 receptors
Nefazodone
Weak inhibitors of serotonin reuptake (similar to SSRIs, just weaker)
Trazodone
Weak inhibitors of serotonin reuptake (similar to SSRIs, just weaker)