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Pharmacology > MOA: Estrogens and Androgens > Flashcards

MOA: Estrogens and Androgens Flashcards

1
Q

Estradiol

A

Estrogen
Steroid hormone that diffuse across the cell membrane and bind to estrogen receptors inside, stimulating synthesis of specific RNA/protein

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2
Q

Estrone

A

Estrogen
Steroid hormone that diffuse across the cell membrane and bind to estrogen receptors inside, stimulating synthesis of specific RNA/protein

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3
Q

Estriol

A

Estrogen
Steroid hormone that diffuse across the cell membrane and bind to estrogen receptors inside, stimulating synthesis of specific RNA/protein

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4
Q

Leuprolide

A

GnRH Analogs
GnRH agonists - pulse dose increases FSH/LH production, and continuous dose decreases FSH/LH production

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5
Q

Gonadorelin

A

GnRH Analogs
GnRH agonists - pulse dose increases FSH/LH production, and continuous dose decreases FSH/LH production

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6
Q

Nafarelin

A

GnRH Analogs
GnRH agonists - pulse dose increases FSH/LH production, and continuous dose decreases FSH/LH production

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7
Q

Raloxifene

A

Selective Estrogen Receptor Modulator (SERM)
-Competes with estrogen for binding in breast tissue.
-Antagonist at breast tissue estrogen receptors - regresses breast cancer.
-Lower the risk of uterine cancer.
-Also decreases bone reabsorption and turnover.

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8
Q

Tamoxifen

A

Selective Estrogen Receptor Modulator (SERM)
-Competes with estrogen for binding in breast tissue
-Antagonist at breast tissue estrogen receptors - regresses breast cancer.
-Agonist at uterus estrogen receptors - increases risk of uterine cancer.

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9
Q

Clomiphene

A

Selective Estrogen Receptor Modulator (SERM)
-Acts as estrogen receptor antagonist at all receptor types
-Major action is to block estrogen-mediated negative feedback in the pituitary
-Increases FSH/LH

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10
Q

Drospirenone

A

Progestogens (Progestins)

Produced in response to LH and promotes the development of secretory endometrium

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11
Q

Levonorgestrel

A

Progestogens (Progestins)

Produced in response to LH and promotes the development of secretory endometrium

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12
Q

Medroxyprogesterone

A

Progestogens (Progestins)

Produced in response to LH and promotes the development of secretory endometrium

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13
Q

Megestrol

A

Progestogens (Progestins)

Produced in response to LH and promotes the development of secretory endometrium

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14
Q

Norelgestromin

A

Progestogens (Progestins)

Produced in response to LH and promotes the development of secretory endometrium

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15
Q

Norethindrone

A

Progestogens (Progestins)

Produced in response to LH and promotes the development of secretory endometrium

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16
Q

Progesterone

A

Progestogens (Progestins)

Produced in response to LH and promotes the development of secretory endometrium

17
Q

YAZ

A

Drospirenone + Ethinyl estradiol

18
Q

Mifepristone

A

Anti-Progestin

Progesterone antagonist

19
Q

Testosterone

A

Androgen

Steroid hormones that diffuse across the cell membrane and bind to testosterone receptors inside, stimulating synthesis of specific RNA/protein

20
Q

Bicalutamide

A

Anti-Androgen

Androgen receptor antagonist

21
Q

Flutamide

A

Anti-androgen

Androgen receptor antagonist

22
Q

Nilutamine

A

Anti-androgen

Androgen receptor antagonist

23
Q

What are the 3 estrogen hormones?

A

Estradiol
Estrone
Estriol

24
Q

What are the 3 GnRH agonists?

A

Leuprolide
Gonadorelin
Nafarelin

25
Q

What are the 3 selective estrogen receptor modulators (SERMs)?

A

Ramoxifene
Tamoxifen
Clomiphene

26
Q

What are the 7 progestogens?

A

Progesterone
Medroxyprogesterone
Megestrol
Norelgesteromin
Norethindrone
Drospirenone
Levonorgestrel

27
Q

What is the progesterone antagonist?

A

Mifepristone

28
Q

What is the 1 androgen hormone we discuss in this chapter?

A

Testosterone

29
Q

What are the 3 androgen antagonists?

A

Bicalutamide
Flutamide
Nilutamide

“-tamide”

Pharmacology (34 decks)

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