Pro and Anti-Inflammatory Drugs Flashcards
Are prostaglandins anti-inflammatory or pro-inflammatory?
pro-inflammatory
What prostaglandin is an Agonist at prostaglandin E1 receptors on parietal cells (GI system)?
Misoprostol
What prostaglandin is an agonist at prostacyclin receptors, where binding increases cAMP production and causes pulmonary vasodilation?
Iloprost
What prostaglandin binds to prostaglandin FP receptors?
Latanoprost, Travoprost, Bimatoprost
Main effects for misoprostol (2)
1) Reduces gastric acid secretion
2) Stimulates mucus and bicarbonate production
Main effects for Iloprostol
Pulmonary vasodilation
Main effects for Latanoprost, Travoprost, Bimatoprost (2)
1) Increase uveoscleral outflow (not trabecular)
2) Reduce IOP
When would you use misoprostol?
Labor induction because it protects the Gi system and mucosal lining during chronic NSAID treatment
What drug would you take for pulmonary hypertension?
Iloprost
What drugs would you take for glaucoma treatment?
Latanoprost, travoprost, bimatoprost
How is Iloprost administered?
Inhalation
What drug may causes Diarrhea, abdominal pain, headache, and may induce abortion?
Misoprostol
What pro-inflammatory drug causes headache, dizziness, flushing?
iloprost
What drug causes blurred vision, increase iris pigmentation, increased pigment of eyelashes, and eye redness?
Latanoprost, travoprost, bimatoprost
Is aspirin pro or anti-inflammatory?
Anti-inflammatory
What are the main effects of aspirin? (5)
1) Analgesic, anti-inflammatory, anti-pyretic
2) Increased alveolar ventilation/respiration
3) Increased gastric acid production (bad)
4) Decrease in protective GI mucous (bad)
5) Inhibits platelet aggregation
When would you use aspirin?
treat pain, anti-inflammatory, and reduce fever
What is the only irreversible NSAID?
aspirin
Adverse effects of aspirin
Gi issues
Potential risk of serious CV thrombosis, MI, and stroke
Prolong bleeding
Hypersensitivity
Drug interactions
When should you avoid taking aspirin?
In children and teenagers with viral infection
A child has Reye syndrome (hepatitis with edema), what would you give them?
NSAID other than aspirin
Are COX-2 NSAIDS anti-inflammatory or pro-inflammatory?
anti-inflammatory
What are COX-2 NSAIDS main effects?
- Analgesic, anti-inflammatory, anti-pyretic
- Increased alveolar ventilation/respiration
- Inhibits platelet aggregation
Do COX-2 NSAIDS have more or less side effects?
Less side effects but can still cause GI issues
What drug is a DMARD and is used in cancer treatment?
Methotrexate
What DMARD has subQ/IV administration and cannot be used with IL-1 antagonists (anakinra)?
TNF inhibitors
What DMARD has a subQ injection once a day and can’t be combined with TNF inhibitors?
Anakinra
What do DMARDS treat?
Rheumatoid arthritis and other chronic inflammatory diseases
What kind of adverse effects does hydroxychloroquine have?
GI upset
Skin rash
HA
Bull’s eye maculopathy
○ Unknown cause
○ Permanent vision loss
○ Requires yearly exam with central VF/OCT
What drug can cause Bull’s eye maculopathy?
Hydroxychloroquine
Adverse effects of TNF inhibitors (4)
1) Increased infection risk
2) Cannot administer with live vaccines
3) Can worsen pre-existing HF
4) Increased risk of cancer/lymphoma
