MOA: Skeletal Muscle Relaxants

Question 1

Succinlycholine

Answer 1

Depolarizing Agent (Nicotinic receptor agonist)

Binds to the nicotinic receptor to open the ion channel and cause depolarization, similar to ACh

Question 2

Cisatracurium

Answer 2

Non-Depolarizing Agents (Nicotinic receptor antagonist)

Compete with ACh for binding site

Question 3

Rocuronium

Answer 3

Non-Depolarizing Agents (Nicotinic receptor antagonist)

Compete with ACh for binding site

Question 4

Vecuronium

Answer 4

Non-Depolarizing Agents (Nicotinic receptor antagonist)

Compete with ACh for binding site

Question 5

Baclofen

Answer 5

Centrally-Acting Spasmolytic Drugs

Main effect at GABA receptors

Question 6

Carisoprodol

Answer 6

Centrally-Acting Spasmolytic Drugs

Interrupts neuronal communication, producing sedation/altered pain perception

Question 7

Cyclobenzaprine

Answer 7

Centrally-Acting Spasmolytic Drugs

Main effects at NE and 5-HT receptors

Question 8

Tizanidine

Answer 8

Centrally-Acting Spasmolytic Drugs

Main effect at alpha-2 receptors

Question 9

Gabapentin

Answer 9

Centrally-Acting Spasmolytic Drugs

Thought to bind to a carrier protein at a unique receptor, resulting in elevated GABA levels in the brain

Question 10

Dantrolene

Answer 10

Direct-Acting Muscle Relaxant

Prevents release of calcium by blocking the channel in the sarcoplasmic reticulum

Question 11

What are the non-depolarizing agents that compete with acetylcholine for the binding site?

Answer 11

Cisatracurium
Rocuronium
Vecuronium

Question 12

What are the centrally-acting spasmolytic drugs?

Answer 12

Baclofen
Carisoprodol
Cyclobenzaprine
Tizanidine
Gabapentin

Question 13

What drug is a direct acting muscle relaxant?

Answer 13

Dantrolene

Question 14

What drug is a depolarizing agent?

Answer 14

Succinlycholine