MOA: Pro and Anti-inflammatory Drugs (Non-steroidal)

Question 1

Misoprostol

Answer 1

Prostaglandin agonists (proinflammatory)

-Agonist at prostaglandin receptors on parietal cells in the GI system
-Reduce gastric acid secretion
-Stimulate mucus and bicarbonate production

Question 2

Iloprost

Answer 2

Prostaglandin agonists (proinflammatory)

Agonist at prostacyclin receptors, where binding increases production of cAMP and causes pulmonary vasodilation

Question 3

Latanoprost

Answer 3

Prostaglandin agonists (proinflammatory)

Bind to prostaglandin FP receptors and increase uveoscleral outflow
-Reduces IOP

Question 4

Travoprost

Answer 4

Prostaglandin agonists (proinflammatory)

Bind to prostaglandin FP receptors and increase uveoscleral outflow
-Reduces IOP

Question 5

Bimatoprost

Answer 5

Prostaglandin agonists (proinflammatory)

Bind to prostaglandin FP receptors and increase uveoscleral outflow
-Reduces IOP

Question 6

Aspirin

Answer 6

NSAIDs

Inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase enzymes COX-1 and COX-2

Irreversibly inactivates cyclooxygenase, whereas all other NSAIDs are reversible

Question 7

Indomethacin

Answer 7

NSAIDs
Acetic and propionic acid

Inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase enzymes COX-1 and COX-2

Question 8

Ibuprofen

Answer 8

NSAIDs
Acetic and propionic acid

Inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase enzymes COX-1 and COX-2

Question 9

Diclofenac

Answer 9

NSAIDs
Acetic and propionic acid

Inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase enzymes COX-1 and COX-2

Question 10

Naproxen

Answer 10

NSAIDs
Acetic and propionic acid

Inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase enzymes COX-1 and COX-2

Question 11

Ketorolac

Answer 11

NSAIDs
Acetic and propionic acid

Inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase enzymes COX-1 and COX-2

Question 12

Meloxicam

Answer 12

NSAIDs
Oxicam

NSAID preferential for COX-2
Inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase enzymes COX-1 and COX-2

Question 13

Piroxicam

Answer 13

NSAIDs
Oxicam

Inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase enzymes COX-1 and COX-2

Question 14

Celecoxib

Answer 14

NSAIDs

inhibits COX-2 specificly

Inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase enzymes COX-1 and COX-2

Question 15

Acetaminophen (Tylenol)

Answer 15

Acetaminophen

Inhibits prostaglandin synthesis, similar to COX-2 specific drugs, but with higher activity in the CNS

Question 16

Hydroxychloroquine

Answer 16

Drugs for Arthritis (DMARD)

-Increases pH within inflammatory cells, leading to interference with “antigen processing”
-Decreases stimulation of CD4 cells
-Decreases the inflammatory reaction

Question 17

Methotrexate

Answer 17

Drugs for Arthritis (DMARD)

Inhibits dihydrofolate reductase

Question 18

Adalimumab

Answer 18

Drugs for Arthritis (DMARD)

Inhibit the TNF-alpha cytokine

Question 19

Certolizumab

Answer 19

Drugs for Arthritis (DMARD)

Inhibit the TNF-alpha cytokine

Question 20

Etanercept

Answer 20

Drugs for Arthritis (DMARD)

Inhibit the TNF-alpha cytokine

Question 21

Golimumab

Answer 21

Drugs for Arthritis (DMARD)

Inhibit the TNF-alpha cytokine

Question 22

Infliximab

Answer 22

Drugs for Arthritis (DMARD)

Inhibit the TNF-alpha cytokine

Question 23

Anakinra

Answer 23

Drugs for Arthritis (DMARD)

IL-1 antagonist

Question 24

Abatacept

Answer 24

Drugs for arthritis (DMARD)

Inhibits T-cell activation

Question 25

Tocilizumab

Answer 25

Drugs for arthritis (DMARD)

Inhibits IL-6

Question 26

Tofacitinib

Answer 26

Drugs for arthritis (DMARD)

Regulates immune cell function