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Pharmacology > MOA: Pro and Anti-inflammatory Drugs (Non-steroidal) > Flashcards

MOA: Pro and Anti-inflammatory Drugs (Non-steroidal) Flashcards

1
Q

Misoprostol

A

Prostaglandin agonists (proinflammatory)

-Agonist at prostaglandin receptors on parietal cells in the GI system
-Reduce gastric acid secretion
-Stimulate mucus and bicarbonate production

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2
Q

Iloprost

A

Prostaglandin agonists (proinflammatory)

Agonist at prostacyclin receptors, where binding increases production of cAMP and causes pulmonary vasodilation

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3
Q

Latanoprost

A

Prostaglandin agonists (proinflammatory)

Bind to prostaglandin FP receptors and increase uveoscleral outflow
-Reduces IOP

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4
Q

Travoprost

A

Prostaglandin agonists (proinflammatory)

Bind to prostaglandin FP receptors and increase uveoscleral outflow
-Reduces IOP

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5
Q

Bimatoprost

A

Prostaglandin agonists (proinflammatory)

Bind to prostaglandin FP receptors and increase uveoscleral outflow
-Reduces IOP

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6
Q

Aspirin

A

NSAIDs

Inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase enzymes COX-1 and COX-2

Irreversibly inactivates cyclooxygenase, whereas all other NSAIDs are reversible

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7
Q

Indomethacin

A

NSAIDs
Acetic and propionic acid

Inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase enzymes COX-1 and COX-2

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8
Q

Ibuprofen

A

NSAIDs
Acetic and propionic acid

Inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase enzymes COX-1 and COX-2

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9
Q

Diclofenac

A

NSAIDs
Acetic and propionic acid

Inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase enzymes COX-1 and COX-2

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10
Q

Naproxen

A

NSAIDs
Acetic and propionic acid

Inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase enzymes COX-1 and COX-2

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11
Q

Ketorolac

A

NSAIDs
Acetic and propionic acid

Inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase enzymes COX-1 and COX-2

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12
Q

Meloxicam

A

NSAIDs
Oxicam

NSAID preferential for COX-2
Inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase enzymes COX-1 and COX-2

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13
Q

Piroxicam

A

NSAIDs
Oxicam

Inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase enzymes COX-1 and COX-2

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14
Q

Celecoxib

A

NSAIDs

inhibits COX-2 specificly

Inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase enzymes COX-1 and COX-2

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15
Q

Acetaminophen (Tylenol)

A

Acetaminophen

Inhibits prostaglandin synthesis, similar to COX-2 specific drugs, but with higher activity in the CNS

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16
Q

Hydroxychloroquine

A

Drugs for Arthritis (DMARD)

-Increases pH within inflammatory cells, leading to interference with “antigen processing”
-Decreases stimulation of CD4 cells
-Decreases the inflammatory reaction

17
Q

Methotrexate

A

Drugs for Arthritis (DMARD)

Inhibits dihydrofolate reductase

18
Q

Adalimumab

A

Drugs for Arthritis (DMARD)

Inhibit the TNF-alpha cytokine

19
Q

Certolizumab

A

Drugs for Arthritis (DMARD)

Inhibit the TNF-alpha cytokine

20
Q

Etanercept

A

Drugs for Arthritis (DMARD)

Inhibit the TNF-alpha cytokine

21
Q

Golimumab

A

Drugs for Arthritis (DMARD)

Inhibit the TNF-alpha cytokine

22
Q

Infliximab

A

Drugs for Arthritis (DMARD)

Inhibit the TNF-alpha cytokine

23
Q

Anakinra

A

Drugs for Arthritis (DMARD)

IL-1 antagonist

24
Q

Abatacept

A

Drugs for arthritis (DMARD)

Inhibits T-cell activation

25
Q

Tocilizumab

A

Drugs for arthritis (DMARD)

Inhibits IL-6

26
Q

Tofacitinib

A

Drugs for arthritis (DMARD)

Regulates immune cell function

Pharmacology (34 decks)

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