Primary Sclerosing Cholangitis Flashcards
What type of condition is Primary Sclerosing cholangitis?
Chronic inflammatory condition
What happens in Primary Sclerosing Cholangitis?
Intrahepatic or extrahepatic ducts become strictured and fibrotic
What does the stricturing and fibrosis of the ducts lead to?
Obstruction to the flow of bile out of the liver into the intestines
What does sclerosis mean?
Stiffening and hardening of the bile ducts
What is cholangitis?
Inflammation of the bile ducts
What does chronic bile obstruction result in?
Liver inflammation, Fibrosis and cirrhosis
What does Primary Sclerosing Cholangitis usually occur alongside?
Ulcerative colitis
What is the main risk factors of Primary Sclerosing Cholangitis?
Ulcerative colitis
How does Primary Sclerosing Cholangitis present?
Pruritis
Jaundice
RUQ pain
Hepatomegaly
How is Primary Sclerosing Cholangitis diagnosed?
P-ANCA
LFT’s
ERCP/ MRCP
What would LFT’s show with Primary Sclerosing Cholangitis?
Raised ALP
Raised bilirubin
What is the gold standard investigation of Primary Sclerosing Cholangitis?
MRCP
What is ERCP and MRCP used for?
Visualise the bile duct abnormalities
What is the main complication of Primary Sclerosing Cholangitis?
Cholangiocarcinoma
What are the other possible complications of Primary Sclerosing Cholangitis?
Cirrhosis
Oesophageal varices
