Non-Alcoholic Fatty Liver Disease

Question 1

What is the progression of Non-alcoholic Fatty Liver Disease?

Answer 1

Steatosis- fat in the liver
Steatohepatitis- fat with inflammation
Progresses to fibrosis and cirrhosis

Question 2

What are the main causes of Non-alcoholic fatty liver disease?

Answer 2

• Obesity
• High cholesterol
• High BP
• Smoking
• Type 2 diabetes

Question 3

How is Non-alcoholic Fatty Liver Disease diagnosed?

Answer 3

Ultrasound of liver

Question 4

What would you find on an US of Non-alcoholic Fatty Liver Disease?

Answer 4

Hepatomegaly- Increased echogenicity of the liver

Question 5

What is the most common presentation of Non-alcoholic Fatty Liver Disease?

Answer 5

Asymptomatic

Question 6

What other investigations would you do for Non-alcoholic Fatty Liver Disease?

Answer 6

ALT and AST

Non-invasive liver test- FIB-4 and NAFLD fibrosis score

Question 7

What would be the result of ALT and AST if someone had Non-alcoholic fatty liver disease?

Answer 7

ALT greater than AST

Question 8

What is the management of NAFLD?

Answer 8

Lifestyle changes

• -Weight loss
• -Exercise
• -Stop smoking

Question 9

What medical treatment can you give for liver fibrosis?

Answer 9

Vitamin E

Pioglitazone