Autoimmune Hepatitis Flashcards
What is autoimmune hepatitis characterised by?
Increased IgG levels
Antibodies against liver specific and non-liver specific antibodies
Mononuclear infiltrate within the liver
What does autoimmune hepatitis cause if it lasts longer than 6 months?
Chronic hepatitis
What is the pathophysiology of autoimmune hepatitis?
Genetically predisposed individual comes into contact with environmental trigger
What is an environmental trigger for autoimmune hepatitis?
Hepatitis c
What are the 2 types of autoimmune hepatitis?
Type 1
Type 2
Who does type 1 autoimmune hepatitis affect?
Women
Late 40/50- around menopause
How does type 1 autoimmune hepatitis present?
Fatigue
Features of liver disease
Which antibodies are present in type 1 autoimmune hepatitis?
Anti-nuclear antibodies (ANA)
Anti-smooth muscle antibodies (anti-actin)
Anti-soluble liver antigen
What is the main investigation for autoimmune hepatitis?
Raised Transaminases (ALT and AST) Raised IgG
Which type of autoimmune hepatitis has a more acute onset?
Type 2
Who does type 2 autoimmune hepatitis normally affect?
Occurs in teenagers and early 20’s
How does type 2 autoimmune hepatitis present?
Acute hepatitis
High transaminase
Jaundice
What 2 anti-liver organisms will be present in type 2 autoimmune hepatitis?
Anti-liver kidney microsomes
Anti-liver cytosol antigen type 1
How is autoimmune hepatitis diagnosed?
Liver biopsy
What is the management of autoimmune hepatitis?
High dose prednisolone
