Pharmacology - Polypharmacy (Exam 6) Flashcards
many drugs used appropriately + too many drugs used inappropriately
Polypharmacy
The most common oral implication of poly pharmacy is anticholinergic effects. Name some examples
Salivary hypofunction
Difficulty in speech and swallowing
Impaired taste
Overall drug burden is an important consideration due to _______________ effects
hidden
Explain the impact of non-optimized medication therapy on morbidity and mortality
Non-optimized medication therapy is estimate to result in 275,869 deaths per year in the United States.
The annual cost of drug related morbidity and mortality resulting from nonoptimized medication therapy is estimated to be $526.4 billion.
Which population is most sensitive to the harmful effects of poly pharmacy?
Older adults
Identify patient factors contributing to the syndrome of polypharmacy.
-absorption
-distribution
-metabolism
-excretion
(not sure if this is what she’s looking for)
Name some strategies to fight poly pharmacy risk
1) individualize care
2) avoid common errors
3) systematic approach
Pharmacokinetic food-drug interactions are linked to __________ therapeutic index are notable
narrow
T/F: Gastric motility can be increased by polypharmacy.
False! it’s slowed
Describe the ionization of Warfarin
Low pH = neutral species
High pH = ionized species
Two drugs that interact w/ food
-uroxatrol
-flomax
As we age, the distribution of drugs is affected. How?
Decreased serum albumin
Increased alpha-1-acid glycoprotein
Blood brain barrier
Which Phase of hepatic metabolism is likely to be prolonged in adults?
phase I
T/F: Cyp enzymes can be inducted or inhibited by polypharmacy
True
Fluoxetine is a strong inhibitor of which CYP?
2D6
