Pharmacology - Non-Opioid Analgesics and Antagonists (Exam 3) Flashcards
Which of the following enzymes are inhibited by non-steroidal anti-inflammatory drugs?
a. cyclooxygenase 1
b. calpain 1
c. cyclooxygenase 2
d. cytochrome c reductase
e. both cyclooxygenase 1 and cyclooxygenase 2
e. both cyclooxygenase 1 and cyclooxygenase 2
Which NSAID is an irreversible inhibitor of cyclooxygenase 1 and is used at low doses for anti-platelet prophylaxis?
a. ibuprofen
b. aspirin
c. acetaminophen
d. ketoprofen
e. naproxen
b. aspirin
Mrs. Jennings visits the office to have a cavity filled in one of her molars. After the procedure she comments that she is having jaw pain and ask whether there is something she can take for it?
Her past medical history reveals an allergy to pain relievers. You ask her
about it and she says that it was an over the counter
pain reliever, maybe aspirin but she can’t be sure.
Based on this information, what pain reliever do you
recommend to Mrs. Jennings to minimize her chances of having an allergic reaction?
a. ibuprofen
b. naproxen
c. aspirin
d. acetaminophen
e. diflunisal
d. acetaminophen
Mr. Anderson is a 44 year old recovering heroine addict who has been drug free for 3 years. He comes into the office to have a consultation for a fairly involved oral surgical procedure.
In planning his surgery you are concerned about pain management. Given that he is likely to experience moderate to severe pain, a good treatment option, all things considered, would be to plan to administer what drug?
a. aspirin
b. acetaminophen
c. celecoxib
d. ibuprofen/oxycodone
e. ketorolac
e. ketorolac
Which of the following statements is correct?
(a) Inhibition of cyclooxygenase 1 has no effect on
coagulation.
(b) Inhibition of cyclooxygenase 1 tends to promote
coagulation.
(c) Inhibition of cyclooxygenase 2 tends to inhibit
coagulation.
(d) Inhibition of cyclooxygenase 2 tends has no effect on
coagulation.
(e) Inhibition of
cyclooxygenase 1 tends to inhibit coagulation, and inhibition of cyclooxygenase 2 tends to
promote coagulation.
(e) Inhibition of
cyclooxygenase 1 tends to inhibit coagulation, and inhibition of cyclooxygenase 2 tends to
promote coagulation.
Clinical studies suggest that the most effective mild to
moderate pain relief for routine dental procedures is achieved with which of the following drugs?
a. NSAIDs
b. acetaminophen
c. opioids
d. either NSAIDs or acetaminophen
e. either NSAIDs or opioids
d. either NSAIDs or acetaminophen
Your patient’s pain is almost, but not completely
controlled with maximum doses of the NSAID you
prescribed.
You suspect an analgesic plateau effect is
at work.
Which additional drug do you prescribe to
overcome the plateau effect and alleviate the pain?
a. aspirin
b. acetaminophen
c. ibuprofen
d. naproxen
e. diflunasil
b. acetaminophen
Which of these medical diagnoses is not a
contraindication to NSAID use?
a. pregnancy
b. acute renal failure
c. asthma
d. perforated ulcer
e. arthritis
e. arthritis
Ms. Jones is an 80-year-old female. She has arthritis
and is on warfarin therapy for congestive heart failure.
She is scheduled for a moderately painful dental
procedure.
You want to be able to treat her post-op pain but minimize exacerbation of her anticoagulated state. Which medication do you choose?
a. aspirin
b. celecoxib
c. diflusanil
d. ketorolac
e. ibuprofen/oxycodone
b. celecoxib
Which of these anti-inflammatory medicines is useful for treating Gout but does not inhibit cyclooxygenase?
a. indomethacin
b. naproxen
c. ketoprofen
d. colchicine
e. aspirin
d. colchicine
NSAID contraindications
Nursing and pregnancy
Serious bleeding
Allergy, asthma, angioedema
Impaired renal function
Drug (anticoagulant)
