Pharmacology - Drug Abuse and Marijuana (Exam 6)

Question 1

Preoccupation with the use and procurement of a drug. The individual feels that the drug is needed for their continued well being.

Answer 1

Compulsive drug use

Question 2

behavioral pattern of compulsive drug use

Answer 2

Addiction

Question 3

Natural reward examples

Answer 3

Food
Sex
Water
Nurturing

Question 4

The reward pathway in the brain involves which neurotransmitter?

Answer 4

Dopamine

Question 5

Altered physiological state as a result of chronic drug use

Answer 5

Physical dependence

Question 6

Degree of physiological dependence can be determined by the severity of the?

Answer 6

Withdrawal

Question 7

Withdrawal intensity is related to the degree of altered function. Name 3 things that cause this

Answer 7

1) high doses
2) frequent administration
3) long periods of use

Question 8

More drug is needed to elicit the same response

Answer 8

Tolerance

Question 9

3 types of tolerance

Answer 9

1. Metabolic/pharmacokinetic
2. Cellular/pharmacodynamic
3. Reverse/sensitization

Question 10

Less drugs get to the site of action

Answer 10

Metabolic tolerance

Question 11

Same amount of drug gets to the site of action but the response is reduced

Answer 11

Pharmacodynamic/cellular tolerance

Question 12

Describe the 2 types of reinforcements

Answer 12

(+): drug induces euphoria/pleasure
(-): drug terminates pain, anxiety

Question 13

Examples of secondary reinforcers

Answer 13

Sight of the drug, environment in which drug was taken

Question 14

Name some opioids (5)

Answer 14

Heroin
Morphine
Naltrexone
Methadone
Buprenorphine

Question 15

MOA of opioids

Answer 15

Opioid receptor agonist
(opioids receptors = GPCR’s)

Question 16

Morphine binds to ____________ receptors in the reward pathway

Answer 16

opiate

Question 17

Name some hallucinogens

Answer 17

Pyschedelics: LSD, mecaline, psilocin, psilocybin,
Deliriants: PCP, Ketamine, THC

Question 18

MOA of LSD

Answer 18

Serotonin receptor agonist

Question 19

MOA of an LSD-Like drug: Mescaline

Answer 19

Serotonin receptor agonist

Question 20

MOA Psilocybin/Psilocin

Answer 20

Serotonin receptor agonist

Question 21

Psilocybin/psilocin

Answer 21

Mushrooms

Question 22

MOA of PCP

Answer 22

Noncompetitive antagonist of NMDA receptor

Question 23

MOA of ketamine

Answer 23

Noncompetitive antagonist of NMDA receptor

Question 24

How does amphetamine increase extracellular dopamine? (2 ways)

Answer 24

1) competitively inhibits DA reuptake
2) causes release of DA

Question 25

MOA of methamphetamine

Answer 25

Inhibit DA reuptake and cause release of dopamine

Question 26

MOA of MDMA

Answer 26

Reverses the action of the serotonin transporter

Question 27

Another name for MDMA

Answer 27

Ecstasy/molly

Question 28

Name some uses of amphetamine

Answer 28

1) ADD
2) obesity
3) narcolepsy

Question 29

MOA of methyphenidate

Answer 29

inhibit DA reuptake

Question 30

Drug of choice for ADD

Answer 30

methylphenidate (Ritalin)

Question 31

MOA of cocaine

Answer 31

Block reuptake of biogenic amines, primarily dopamine

Question 32

Methadone maintenance is a ___________ agonist for the treatment of ________ dependence

Answer 32

mu; opioid

Question 33

Our fav opioid antagonist

Answer 33

Naltrexone

Question 34

_______________ is a partial agonist of the mu receptor

Answer 34

Buprenorphine

Question 35

What is the active principal in marijuana?

Answer 35

9 - tetrahydrocannabinol (Δ9 -THC)

Question 36

MOA of marijuana

Answer 36

Binds to cannabinoid receptor