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D1 Spring > Pharmacology - Antidepressants and Antipsychotics (Exam 1) > Flashcards

Pharmacology - Antidepressants and Antipsychotics (Exam 1) Flashcards

1
Q

What are the tricyclic antidepressants?

A

Imipramine
Amitriptyline

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2
Q

What do tricyclic antidepressants (Imipramine, Amitriptyline) block?

A

blocks NE and serotonin reuptake

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3
Q

What generation are tricyclic antidepressants?

A

1st generation

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4
Q

What are the selective serotonin reuptake inhibitors (SSRIs)?

A

Fluoxetine (Prozac, Sarafem)
Sertraline (Zoloft)

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5
Q

What do selective serotonin reuptake inhibitors (SSRIs) block?

A

selectively block reuptake of serotonin
(also prolong post- and pre-synaptic activity of serotonin; produce CNS excitation)

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6
Q

What are the serotonin/norepinephrine reuptake inhibitors (S/NRIs)?

A

Venlafaxine (Effexor)
Duloxetine (Cymbalta)

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7
Q

What do serotonin/norepinephrine reuptake inhibitors (S/NRIs) block?

A

blocks NE and serotonin reuptake

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8
Q

What are the monoamine oxidase inhibitors (MAOIs)?

A

Phenelzine (non-selective)
Selegiline (Emsam) (MAO-B selective)

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9
Q

What do monoamine oxidase inhibitors (MAOIs) block?

A

block NE and serotonin reuptake

(irreversibly bind MAO-A and MAO-B)

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10
Q

What generation are monoamine oxidase inhibitors (MAOIs)?

A

1st and 2nd generation

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11
Q

What generation are selective serotonin reuptake inhibitors (SSRIs)?

A

2nd generation

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12
Q

What generation are serotonin/norepinephrine reuptake inhibitors (S/NRIs)?

A

2nd generation

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13
Q

What are the typical antipsychotics?

A

Chlorpromazine
Thioridazine
Haloperidol
Molindone

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14
Q

What are the atypical antipsychotics?

A

Clozapine
Olanzipine
Risperidone
Aripiprazole

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15
Q

What do the typical antipsychotics block?

A

dopamine

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16
Q

What do the atypical antipsychotics block?

A

dopamine and serotonin

17
Q

Which antipsychotics have extrapyramidal (motor) side effects?

A

typical

18
Q

Which antipsychotics are first line drugs?

A

atypical

19
Q

What can Clozapine cause?

A

agranulocytosis (low WBC count) after 4-16 weeks of Rx in 1% of patients

20
Q

Which antidepressants are first line drugs?

A

SSRIs
SNRIs

21
Q

Which antidepressants are second line drugs?

A

TCAs
MAOIs

D1 Spring (47 decks)

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