Pharmacology - Drugs Acting on Respiratory System (Exam 4)

Question 1

Which of the following choices best describes the difference between the mechanism of action of anticholinergics and β2-adrenergic agonists in the lungs of asthma patients?

(a) anticholinergics decrease bronchoconstriction whereas
β2-adrenergic agonists increase bronchodilation
(b) anticholinergics increase bronchodilation whereas
β2-adrenergic agonists decrease bronchoconstriction
(c) both anticholinergics and β2-adrenergic agonists inhibit conversion of cAMP to AMP
(d) anticholinergics increase bronchodilation whereas
β2-adrenergic agonists decrease bronchoconstriction
(e) none of these

Answer 1

(a) anticholinergics decrease bronchoconstriction whereas
β2-adrenergic agonists increase bronchodilation

Question 2

Which bronchodilator inhibits the conversion of cAMP to
AMP?

(a) theophylline
(b) albuterol
(c) ipratropium
(d) salmeterol
(e) all of these

Answer 2

(a) theophylline

Question 3

Which of the following drug classes is useful for decreasing the presence of mucus in asthma and COPD
patients?

(a) antitussives
(b) anticholinergics
(c) corticosteroids
(d) both anticholinergics and corticosteroids
(e) all of these

Answer 3

(d) both anticholinergics and corticosteroids

?

Question 4

β2-adrenergic agonists are synthesized and administered as enantiomeric mixtures. Long term use of which β2-adrenergic agonist(s) is most associated with receptor downregulation and adverse effects?

(a) L-enantiomer of short acting β2-adrenergic agonists
(b) L-enantiomer of long acting β2-adrenergic agonists
(c) S-enantiomer of short acting β2-adrenergic agonists
(d) S-enantiomer of long acting β2-adrenergic agonists
(e) both the L-enantiomers of short and long acting β2-adrenergic agonists

Answer 4

(d) S-enantiomer of long acting β2-adrenergic agonists

Question 5

Leukotriene antagonists (Montelukast, Zafirlukast) block
binding of all of the following leukotrienes to the CysLT1 receptor except?

(a) LTB4
(b) LTC4
(c) LTD4
(d) LTE4
(e) none of these

Answer 5

(a) LTB4

Question 6

Leukotriene inhibitors (Zileuton) block production of which of the following leukotrienes?

(a) LTB4
(b) LTC4
(c) LTD4
(d) LTE4
(e) all of these

Answer 6

(e) all of these

Question 7

Which of these medications is most effective as an adjunctive therapy for treating asthma patients with allergies?

(a) Codeine
(b) Dextromethorphan
(c) Noscapine
(d) Omalizumab
(e) Guaifenesin

Answer 7

(d) Omalizumab

Question 8

Which of these classes of medications is preferred for
intermittent treatment of asthma patients?

(a) long acting β2-adrenergic agonists
(b) anticholinergic
(c) short acting β2-adrenergic agonists
(d) inhaled corticosteroid
(e) oral corticosteroid

Answer 8

(c) short acting β2-adrenergic agonists

Question 9

In general, COPD patients benefit by being treated with a combination of which medication classes?

(a) anticholinergic + β2-adrenergic agonist
(b) anticholinergic + inhaled corticosteroid
(c) β2-adrenergic agonist + inhaled corticosteroid
(d) inhaled corticosteroid + omalizumab
(e) oral corticosteroid + anticholinergic

Answer 9

(a) anticholinergic + β2-adrenergic agonist

Question 10

Essential component(s) of a clinical office medical emergency kit include?

(a) Omalizumab
(b) Oxygen
(c) Cromolyn sodium
(d) Epinephrine
(e) Oxygen and Epinephrine

Answer 10

(e) Oxygen and Epinephrine

Question 11

Which of these medications is available over the
counter to treat mild asthma exacerbations but is more likely to increase blood pressure than selective beta 2 adrenergic agonist medications?

(a) Omalizumab
(b) Albuterol
(c) Cromolyn sodium
(d) Primatene Mist
(e) Beclomethosone

Answer 11

(d) Primatene Mist