Pharmacology of Arthritis Flashcards
negative effects of NSAIDs
peptic ulcers oesophagitis gastritis dyspepsia renal impairment increased CV risk asthma exacerbation wheeze
when should DMARDs be commenced
as early as possible, before 3 months of having the disease
which arthritis drugs will alleviate symptoms
analgesics
NSAIDs
name DMARDs used in arthritis?
methotrexate
sulfasalazine
hydrocychloroquine
leflunomide
name biologic agents used in arthrtis?
anti-TNF
rituximab
tocilizumab
name some stronger analgesics than paracetamol used in arthritis?
co-codamol dihydrocodeine tramadol amitryptiline gabapentin
what are the steps of pain management?
1) non-opiod eg paracetamol
2) weak opiod eg codeine
3) strong opiod eg morphine
what kind of drug is naproxen
NSAID
what kind of drug is diclofenac
NSAID
main contraindication of giving a COX2 inhibitor
increases CV events
do DMARDs have an analgesic effect?
no
how long do DMARDs take to work?
weeks to months
methotrexate side effects?
low WCC -> infection hepatitis pneumonitis rash/mouth ulcers nausea/diarrhoea
how often are arthritis patients seen in GP?`
monthly
what should you do if DMARD isn’t proving effective?
add another eg sulfasalazine