Immunology of Autoimmune Disease Flashcards
what is the role of MHC
antigen presentation to CD8+ and CD4+ cells
what is a monogenic disorder
single gene defect causing autoimmune disorder
give an example of genes that play a part in in autoimmune diseases
HLA genes
sex genes
what diseases make up IPEX syndrome?
immunedysregulation
polyendocrinopathy
enteropathy
x linked inheritance
clinical features of IPEX syndrome
severe infections intractable diarrhoea eczema early onset of type 1 diabetes autoimmune conditions
treatment of IPEX syndrome
haematopoetic stem cell transplantation
immunosuppression
parenteral nutrition
which age group is affected by IPEX syndrome?
children
what is the mutation in IPEX syndrome?
FOXP3 gene
what is central tolerance
T reg cells removing self reactive lymphocytes in primary lymphoid tissues
what is peripheral tolerance
inactivation of self reactive lymphocytes that escape central tolerance
pathogenesis of IPEX sundrome
T regs dont work due to FOXP3 gene so peripheral tolerance isnt completed
another name for MHC?
HLA
what is molecular mimicry
immune system is working normally but when attacking normal antigen it comes into contact with self antigen
what type of hypersensitivity disease is SLE?
3
what type of hypersensitivity is RA?
4
