Pharmacology for GI

Question 1

Cimetidine

Answer 1

H2 blocker

Question 2

Ranitidine

Answer 2

H2 blocker

Question 3

Famotidine

Answer 3

H2 blocker

Question 4

Nizatidine

Answer 4

H2 blocker

Question 5

What are important hormonal effects for H2 blockers?

Answer 5

Antiandrogenic

Question 6

What is an important side effect specific to cimetidine and ranitidine?

Answer 6

decreased renal excretion of creatinine

Question 7

What is the mechanism of PPIs?

Answer 7

irreversibly inhibit HKATPase of parietal cells

Question 8

What infections are at increased risk with PPIs?

Answer 8

C. diff, pneumonia

Question 9

Omeprazole

Answer 9

PPI

Question 10

lansoprazole

Answer 10

PPI

Question 11

Bismuth

Answer 11

binds to base of ulcer providing physical protection

Question 12

Sucralfate

Answer 12

binds to base of ulcer providing physical protection

Question 13

Misoprostol

Answer 13

PGE1 analog

Question 14

What are the GI effects of misoprostol

Answer 14

increased production and secreetion of gastric mucous barrier, prevents NSAID peptic ulcers

Question 15

What drug is given to prevent NSAID peptic ulcers?

Answer 15

Misoprostol

Question 16

What electrolyte imbalance can be caused by all antacids?

Answer 16

hypokalemia

Question 17

What antacid can cause diarreha?

Answer 17

MgOH

Question 18

What antacid can cause constipation?

Answer 18

AlOH

Question 19

What are three serious side effects of AlOH

Answer 19

proximal muscle weakness, osteodystrophy, seizures

Question 20

What are serious side effects of MgOH

Answer 20

hypotension, cardiac arrest

Question 21

Infliximab

Answer 21

monoclonal Ab to TNFa

Question 22

Sulfasalazine

Answer 22

combo of sulfapyridine (antibacterial), 5-ASA 9antiinflam)

Question 23

What anti-inflammatory can cause reversible oligospermia?

Answer 23

sulfasalazine

Question 24

Ondanstertron

Answer 24

5-HT3 antag (antiemetic)

Question 25

Metoclorpramide

Answer 25

D2 receptor analog (antiemetic)