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Step 1 > Pharmacology for Endocrinology > Flashcards

Pharmacology for Endocrinology Flashcards

1
Q

Lispro

A

Rapid acting insulin

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2
Q

Aspart

A

Rapid acting insulin

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3
Q

Glulisine

A

Rapid acting insulin

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4
Q

NPH

A

intermediate acting insulin

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5
Q

Glargine

A

long acting insulin

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6
Q

Detemir

A

long acting insulin

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7
Q

Biguanide

A

metformin

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8
Q

Contraindication for metformin

A

Creatinine >1.5

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9
Q

Most serious side effect of metformin

A

lactic acidosis

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10
Q

Tolbutamide

A

Sulfonurea, first generation

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11
Q

Chlorpropamide

A

Sulfonurea, first generation

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12
Q

Glyburide

A

Sulfonurea, second generation

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13
Q

Glimepiride

A

Sulfonurea, second generation

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14
Q

Glipizide

A

Sulfonurea, second generation

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15
Q

Mechanism of sulfonyureas

A

Close K+ channel in b cell membrane, depolarize cell, trigger insulin release

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16
Q

Glitazones (pioglitazone, Rosiglitazone) mechanism

A

bind PPARgamma, incr insulin sensativity in peripheral tissue

17
Q

side effects of glitazones

A

weight gain, edema, hepatotoxicity, heart failure

18
Q

Acarbose

A

a-glucosidase inhibitor

19
Q

Miglitol

A

a-glucosidase inhibitor

20
Q

Mechanism of a-glucosidase inhibitors

A

inhibit intenstinal brush border a-glucosidase, delayed sugar hydrolysis and glucose absorption

21
Q

Pramlintide

A

Amylin analog

22
Q

Mechanism of Amylin analog

A

decr gastric emptying, glucagon

23
Q

Exanatide

A

GLP-1 analog

24
Q

Liraglutide

A

GLP-1 analog

25
Q

Linagliptin

A

DPP-4 inhibitor

26
Q

Saxagliptin, sitagliptin

A

DPP-4 inhibitor

27
Q

Mechanism of GLP-1 analog

A

incr insulin, decr glucagon release

28
Q

Toxicity of GLP-1 analog

A

n/v, pancreatitis

29
Q

Mechanism of DPP-4 inhibitor

A

incr insulin, decr glucagon release

30
Q

Toxcicity of DPP-4 inhibitor

A

mild urinary or respiratory infections

31
Q

Propylthiouracil

A

blocks thyroid peroxidase

32
Q

Methimazole

A

blocks thyroid peroxidase

33
Q

Side effects of propylthiouracil

A

rash, agranulocytosis, aplastic anemia, hepatotoxcicity

34
Q

Hydrocortisone

A

glucocorticoid, Low anti-inflam

35
Q

Prednisone

A

glucocorticoid, medium antiinflamm

36
Q

Triamcinolone

A

glucocorticoid, long-acting antiinflam

37
Q

Dexamethasone

A

glucocorticoid, high anti inflam

38
Q

Fludrocortisone

A

glucocorticoid + mineralicorticoid activity

39
Q

Beclomethasone

A

glucocorticoid, high anti inflam, used topically

Step 1 (34 decks)

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