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Alimentory System > Pathology of lower GIT part 2 > Flashcards

Pathology of lower GIT part 2 Flashcards

1
Q

differnet types of serated neoplaisa

A

hyperplaistic poyp
sessile serated lesion (with or without dysplasia)
traditional serrated adenoma

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2
Q

what size are fhyperplaistic polyp

A

usully less than 5mm

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3
Q

where can hyperlastic polyp occur

A

ussally occur distally around sigmoid/ rectum

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4
Q

what are the common gnetic issues whihc hyperpalistic plyp

A

microvesicular - braf
goblet cell rich - kras

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5
Q

what hapens in ssl lesoin to crypt

A

dilated
irregation
srration at the cryp
branced cryp
horizaotla extion of cryp baess
demataiton of cryps

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6
Q

what ar the common muation for dyspasia for ssl

A

braf
cpg island methylation
mlh-1 defecticy

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7
Q

who is maily effect by mlh 1 defectiy and what is the result

A

women - 45% get cancer

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8
Q

are serrated polyposis associed with malifgy

A

no

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9
Q

where does serrated adenocarcin noramlly occur

A

left side of the colon

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10
Q

what type of archeties is seen with traditional serrated adenoma

A

villiform or filiform architecure
dysplasion
esophgilicy ctoplasia
ectopic crips

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11
Q

what are teh 2 nroaml parts of tradiaotl serrated adenaom

A

classic adenoma
eosinphillic budddig

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12
Q

what are the types of adenoma plyps

A

tubular
villous
tublovillous

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13
Q

what percent of post mortems ahve dysplaia

A

30%

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14
Q

what type of mutaion is noamrly seen with traditoan serrated adenoma

A

kras, braf

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15
Q

what s the differns in sprad between classical adenaoma and serrted adenomaws

A

faster in spread in serrated

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16
Q

what is seen in low grade adenoma

A

incrase in nurlcar no,
incrase nulcar size
reduced mucin

17
Q

what is seen in high grade adeoma

A

carciona
crowded
very irregaurl
non invasive

18
Q

risk factors for colorectal adenocarcinoma

A

lifestyle , family higer, ibd *uc and chrones), genetics, fap , hnpcc, peurtz jeghers

19
Q

what is right sideed colorectal adeno caricoma presention

A

wekness, anaemia, exophyicl / ploypid, obstuction

20
Q

what s left sided adenocarcimoa presation

A

annualr - napkin ring lesion
bleeding (fresh
alterned bowl habbit
obstuciton

21
Q

what is dues cirtera types

A

A - confied to the bowl wall
B - invaded bowl wall but not into lymph nodes
C - Tumour involved with lymph nodes
D Tumor has distal metasists

22
Q

what ar the gentic sin ocloarcal cnaer mutaito that fail

A

kras, and nras, braf, msi

Alimentory System (32 decks)

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