Pathology of lower GIT part 2 Flashcards
differnet types of serated neoplaisa
hyperplaistic poyp
sessile serated lesion (with or without dysplasia)
traditional serrated adenoma
what size are fhyperplaistic polyp
usully less than 5mm
where can hyperlastic polyp occur
ussally occur distally around sigmoid/ rectum
what are the common gnetic issues whihc hyperpalistic plyp
microvesicular - braf
goblet cell rich - kras
what hapens in ssl lesoin to crypt
dilated
irregation
srration at the cryp
branced cryp
horizaotla extion of cryp baess
demataiton of cryps
what ar the common muation for dyspasia for ssl
braf
cpg island methylation
mlh-1 defecticy
who is maily effect by mlh 1 defectiy and what is the result
women - 45% get cancer
are serrated polyposis associed with malifgy
no
where does serrated adenocarcin noramlly occur
left side of the colon
what type of archeties is seen with traditional serrated adenoma
villiform or filiform architecure
dysplasion
esophgilicy ctoplasia
ectopic crips
what are teh 2 nroaml parts of tradiaotl serrated adenaom
classic adenoma
eosinphillic budddig
what are the types of adenoma plyps
tubular
villous
tublovillous
what percent of post mortems ahve dysplaia
30%
what type of mutaion is noamrly seen with traditoan serrated adenoma
kras, braf
what s the differns in sprad between classical adenaoma and serrted adenomaws
faster in spread in serrated
what is seen in low grade adenoma
incrase in nurlcar no,
incrase nulcar size
reduced mucin
what is seen in high grade adeoma
carciona
crowded
very irregaurl
non invasive
risk factors for colorectal adenocarcinoma
lifestyle , family higer, ibd *uc and chrones), genetics, fap , hnpcc, peurtz jeghers
what is right sideed colorectal adeno caricoma presention
wekness, anaemia, exophyicl / ploypid, obstuction
what s left sided adenocarcimoa presation
annualr - napkin ring lesion
bleeding (fresh
alterned bowl habbit
obstuciton
what is dues cirtera types
A - confied to the bowl wall
B - invaded bowl wall but not into lymph nodes
C - Tumour involved with lymph nodes
D Tumor has distal metasists
what ar the gentic sin ocloarcal cnaer mutaito that fail
kras, and nras, braf, msi
