Liver Symposium Flashcards

1
Q

what type of virusse are hep a and e

A

enteric virues

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2
Q

what type of virus are hep, b, c and d

A

parenteral virues

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3
Q

enternic virus meaning

A

infect gi mucosa

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4
Q

parental virus meaning

A

a virus which is transmitted though a route other than the gi tract i.e. sexual transmiaon

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5
Q

waht type of virus is hep a

A

rna virus

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6
Q

what is the transition of hep a

A

faecal - oral , sexual blood

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7
Q

what age group is most associated with hep a

A

5-14 years

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8
Q

how to detect hep a

A

igm antiboides

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9
Q

who is immunised against hep a

A

travellers, patients with chronic liver disease, haemophilic, occupation exposure - lab workers, men who have sex with other men

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10
Q

What are the side effects of hep a

A

cholestasis (pruritus, significant jaundice, dark urine and pale stools)

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11
Q

What is the general presentation of hepatitis

A

Abdominal pain
Fatigue
Flu-like illness
Pruritus (itching)
Muscle and joint aches
Nausea and vomiting
Jaundice

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12
Q

what is the stucure of hep b virus

A

a dna centre which is double straned , with many outer lippinged counting to with hb servfe antigens to stop detionetion

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13
Q

how is hep b transmitted

A

sexual, ivdu, toother brush, razor, contact with open cuts , pregnancy transfer - vericla transmission

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14
Q

what pernet o poeple with hep b recover

A

85%

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15
Q

what does the hepatisu surface antigne signifiy

A

presence of the virus,

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16
Q

what ode shte hepatis e antigne signify

A

active replicaiton

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17
Q

what does hte heaptice core antigen disfiy

A

acive repaltion (this cannont be deteced in blood) - this couleb be past or currne tinfeciotn

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18
Q

what does the hep b bna foundin blood signify

A

active replicatoin

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19
Q

what does hte anit bs antig show

A

protection ie from previosu infection or vaccintation

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20
Q

what does hte igm anti hbc show

A

acute infection

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21
Q

what does hte igg anti hbc show

A

chronci infection/ exposure

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22
Q

what does ht fanti hbe show

A

inactive virus

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23
Q

what treatmen is done for hbsag potive

A

look for igm anti hbc

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24
Q

what are the outcoem for hep b

A

no fuerh progaion
cirrhosis
hepatocelluar carinoma
end stage liver diase

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25
Q

waht antigen is given in hep b vaccination

A

hbsag

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26
Q

what is inclued in management for hep b

A

screening for other viral infections such as hiv, hep a,c and d
avoiding alcohol
education about transmion
contract tracing
testing for compilation i.e. fibrosacn for cirrousi
antiviral medication
pegylated interferon
liver transpaltion

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27
Q

benifit of telivudine tratment for hep b

A

leads to no resiatn bacteria strains

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28
Q

what type of virus is hep c

A

rna

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29
Q

how is hep c frpead

A

blood and boddily fluida dn sex

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30
Q

how is he c cured

A

direct acitign antivurla medication e.g. sofosbuvir and daclatasvir

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31
Q

what paercent of pele develop chroic hep c

A

75%

32
Q

what are complicaions of hep c

A

liver cirrhosis, hepatocelluar carinoma

33
Q

what ar the tests for hep c

A

hep c antibody screening, hep c rna testing

34
Q

what type of virus is hep d

A

rna virus

35
Q

whihc virus does hep d need to live

A

hep b as it needs the hbsag

36
Q

treatmen for hep b and lenght

A

pegylated interferon alpha over 48 weeks

37
Q

dangers of hep d

A

makes all hep b problems worse

38
Q

what type of virus is hep e

A

rna

39
Q

what is the symptosm of hep e

A

very mild and only last one month
can very raley cause hepatis and live failure in immunocompromised paitesn

40
Q

what is the hep g realed to

A

hcv

41
Q

what is the treatmen for parfcetla induced liver failure

A

n acelty cystin infusions

42
Q

what exnme cuaes hte n aceyl p benzqoium inie that is toaxi to pbe prouced

A

cyp450 systems

43
Q

what is the issue with paracentla ob=verudoe

A

glutahoimone is not enough to remove excess toxic substance

44
Q

what are the 3 types of non alcholic fatty liver disease

A

simple steatosis
non alcholic steatohepatitis
fibrosis and cirrhosis

45
Q

risk facots for nafld

A

age, efnicy , genciec e.g. pnpla3 gene

46
Q

what percent of pele with nafld develop steatosi

A

30%

47
Q

what is simple steatosis

A

harmles buildup of fat in liver cells

48
Q

what is non alcholic statohapatis

A

build up of fat that leads to inflation nd scarring

49
Q

path way sof nafld

A

normal livr to statosis, to statohapatis and then cirrhosis

50
Q

chemcial tests for nafld

A

enhanced livr fibross panel, hyaluonic acid, timp and piinp
ast/alt raction
cytokeratin 18 - marker for infection

51
Q

what scans are done for nafld

A

mr/ct, firboscan, ultarions, mr spectoscopys, liver biposy

52
Q

what is the nf score made of

A

age, diabetes, bmi, ast and alt ratio, pltlet cound, albumin

53
Q

what level is nafld score a high risk

A

above 3

54
Q

what makes up fib 4 score

A

age,ast lelve, platatle cound and alt

55
Q

below what score show no fibrosi for fib 4

A

1.45

56
Q

above what score fshow cirrhos for fib 4

A

3.25

57
Q

treatmen for nsadi

A

diet and weight reaction, exercise, insuline sensitzer e.g. metformin or pioglitazone, gluagon like pepdies analogs,
farnesoid x nuclear receptor ligah
vit e
weight reduction surgeries

58
Q

which gender is autoimmune hpatpis mainly in

A

fmeale

59
Q

what is elevated in aueimmuen hepatis

A

igg

60
Q

what are the types of autoimmune hep

A

1 - ana, sma,
2 - lkm1
3 - sla

61
Q

how to diago autoiummen ehp

A

liver bipsy

62
Q

treatmetn for ausotiume hep

A

steroid and long term azathioprine

63
Q

what gender is amily effected by piarmy bilary cholangits

A

femagles

64
Q

what is elaved in primary bilary cholangits

A

igm and anti micobial antibody

65
Q

waht is effected in pairjmy bilary cholangits

A

intrahelpic bile duct

66
Q

what gender is piarmy schlerosing cholagnits

A

males

67
Q

what is postive in primary scholerosing cholangits

A

panca

68
Q

what type of disease is priamry schlering choholangits

A

stircute diseaes

69
Q

signs of pmariy schligsn cholsign

A

recureng cholagit and jaundince

70
Q

treatment for piamry scholign choladn

A

bilary stn if one artery envolvemtn

71
Q

why do we transplant

A

chronic livr disaes with poor prediced survical, poor quailty of live, heapatocllar caricmoa, acure liver failure, gendti disease e.g. oxaluria and tyromia

72
Q

contraidicaiotn for liver transplant

A

extraheaptic maligancy, hepatic maligacy with macrovasualr or diffuse tumore invasion, active and uncontroeled infection outside of the hepatobillary system, active substance and alcohol abuse, sever cardiopmary or other co mordi condion, pycoclal factors which would reclude recover y after transalt, techial or anatomcy barris, brain death

73
Q

how to prioritise in alf

A

ph, inr, arteal lactate, encephalopathy, age, jaudince to encpaty interval

74
Q

socring systms for cirohso

A

chils, meld , ukeld

75
Q

what is the psot opperative drus for over transpaln

A

sterois, azathiopinre, taclimus and cylosporine

76
Q
A