Liver Symposium Flashcards
what type of virusse are hep a and e
enteric virues
what type of virus are hep, b, c and d
parenteral virues
enternic virus meaning
infect gi mucosa
parental virus meaning
a virus which is transmitted though a route other than the gi tract i.e. sexual transmiaon
waht type of virus is hep a
rna virus
what is the transition of hep a
faecal - oral , sexual blood
what age group is most associated with hep a
5-14 years
how to detect hep a
igm antiboides
who is immunised against hep a
travellers, patients with chronic liver disease, haemophilic, occupation exposure - lab workers, men who have sex with other men
What are the side effects of hep a
cholestasis (pruritus, significant jaundice, dark urine and pale stools)
What is the general presentation of hepatitis
Abdominal pain
Fatigue
Flu-like illness
Pruritus (itching)
Muscle and joint aches
Nausea and vomiting
Jaundice
what is the stucure of hep b virus
a dna centre which is double straned , with many outer lippinged counting to with hb servfe antigens to stop detionetion
how is hep b transmitted
sexual, ivdu, toother brush, razor, contact with open cuts , pregnancy transfer - vericla transmission
what pernet o poeple with hep b recover
85%
what does the hepatisu surface antigne signifiy
presence of the virus,
what ode shte hepatis e antigne signify
active replicaiton
what does hte heaptice core antigen disfiy
acive repaltion (this cannont be deteced in blood) - this couleb be past or currne tinfeciotn
what does the hep b bna foundin blood signify
active replicatoin
what does hte anit bs antig show
protection ie from previosu infection or vaccintation
what does hte igm anti hbc show
acute infection
what does hte igg anti hbc show
chronci infection/ exposure
what does ht fanti hbe show
inactive virus
what treatmen is done for hbsag potive
look for igm anti hbc
what are the outcoem for hep b
no fuerh progaion
cirrhosis
hepatocelluar carinoma
end stage liver diase
waht antigen is given in hep b vaccination
hbsag
what is inclued in management for hep b
screening for other viral infections such as hiv, hep a,c and d
avoiding alcohol
education about transmion
contract tracing
testing for compilation i.e. fibrosacn for cirrousi
antiviral medication
pegylated interferon
liver transpaltion
benifit of telivudine tratment for hep b
leads to no resiatn bacteria strains
what type of virus is hep c
rna
how is hep c frpead
blood and boddily fluida dn sex
how is he c cured
direct acitign antivurla medication e.g. sofosbuvir and daclatasvir
what paercent of pele develop chroic hep c
75%
what are complicaions of hep c
liver cirrhosis, hepatocelluar carinoma
what ar the tests for hep c
hep c antibody screening, hep c rna testing
what type of virus is hep d
rna virus
whihc virus does hep d need to live
hep b as it needs the hbsag
treatmen for hep d and lenght
pegylated interferon alpha over 48 weeks
dangers of hep d
makes all hep b problems worse
what type of virus is hep e
rna
what is the symptosm of hep e
very mild and only last one month
can very raley cause hepatis and live failure in immunocompromised paitesn
what is the hep g realed to
hcv
what is the treatmen for parfcetla induced liver failure
n acelty cystin infusions
what exnme cuaes hte n aceyl p benzqoium inie that is toaxi to pbe prouced
cyp450 systems
what is the issue with paracentla ob=verudoe
glutahoimone is not enough to remove excess toxic substance
what are the 3 types of non alcholic fatty liver disease
simple steatosis
non alcholic steatohepatitis
fibrosis and cirrhosis
risk facots for nafld
age, efnicy , genciec e.g. pnpla3 gene
what percent of pele with nafld develop steatosi
30%
what is simple steatosis
harmles buildup of fat in liver cells
what is non alcholic statohapatis
build up of fat that leads to inflation nd scarring
path way sof nafld
normal livr to statosis, to statohapatis and then cirrhosis
chemcial tests for nafld
enhanced livr fibross panel, hyaluonic acid, timp and piinp
ast/alt raction
cytokeratin 18 - marker for infection
what scans are done for nafld
mr/ct, firboscan, ultarions, mr spectoscopys, liver biposy
what is the nf score made of
age, diabetes, bmi, ast and alt ratio, pltlet cound, albumin
what level is nafld score a high risk
above 3
what makes up fib 4 score
age,ast lelve, platatle cound and alt
below what score show no fibrosi for fib 4
1.45
above what score fshow cirrhos for fib 4
3.25
treatmen for nsadi
diet and weight reaction, exercise, insuline sensitzer e.g. metformin or pioglitazone, gluagon like pepdies analogs,
farnesoid x nuclear receptor ligah
vit e
weight reduction surgeries
which gender is autoimmune hpatpis mainly in
fmeale
what is elevated in aueimmuen hepatis
igg
what are the types of autoimmune hep
1 - ana, sma,
2 - lkm1
3 - sla
how to diago autoiummen ehp
liver bipsy
treatmetn for ausotiume hep
steroid and long term azathioprine
what gender is amily effected by piarmy bilary cholangits
femagles
what is elaved in primary bilary cholangits
igm and anti micobial antibody
waht is effected in pairjmy bilary cholangits
intrahelpic bile duct
what gender is piarmy schlerosing cholagnits
males
what is postive in primary scholerosing cholangits
Perinuclear antineutrophil cytoplasmic antibody (p-ANCA)
Antinuclear antibodies (ANA)
Anti-smooth muscle antibodies (anti-SMA)
what type of disease is priamry schlering choholangits
stircute diseaes
signs of pmariy schligsn cholsign
recureng cholagit and jaundince
treatment for piamry scholign choladn
bilary stn if one artery envolvemtn
why do we transplant
chronic livr disaes with poor prediced survical, poor quailty of live, heapatocllar caricmoa, acure liver failure, gendti disease e.g. oxaluria and tyromia
contraidicaiotn for liver transplant
extraheaptic maligancy, hepatic maligacy with macrovasualr or diffuse tumore invasion, active and uncontroeled infection outside of the hepatobillary system, active substance and alcohol abuse, sever cardiopmary or other co mordi condion, pycoclal factors which would reclude recover y after transalt, techial or anatomcy barris, brain death
how to prioritise in alf
ph, inr, arteal lactate, encephalopathy, age, jaudince to encpaty interval
socring systms for cirohso
chils, meld , ukeld
what is the psot opperative drus for over transpaln
sterois, azathiopinre, taclimus and cylosporine
