gut microbiota Flashcards
time taken for food to go form mouth to oesphagus
1 min
tie taken food is in oesphagu
4-8sec
time taken food is in stomac
2-4 horus
time foodn in sin smallninsts
3-5 hours
time of food in colon
10 hours to severla days
where is most of the bacteria in the gi travct
colon
bacteria found in mouth
streptococcus
anticnomyces
veilloneall
fusobacterium
porphromona
prevotella
treponema
common bacerai foudn in stomahc
lactobacciuls
candida
streocouccus
h pylor
peptostreococcus
common bacteira found in duodenu
stretococcus
laptobaccilus
common bacteira found in jejunum and proximal illeum
streptococcus , lactobacilllus
common bacteria foudn in distal illue
clodstidum
strepotcocsu
baceroides
acintomycinase
coryneactaisea
factors which cchagne hte gut micorbia
type of food - solid, formaular fhalthfood, inguriedes, whre it is form
antiboic treamtn
malnution
obses
age
fucntion of gut mboaita
defects agian pahtesn, tough ph inhiobt and barrier
modifes hosts section e.g. mucin and bile
metaboels of diteary compenos
produion of esserion metabolism
development f immune system
host signal - gut to brain axis
what are food which is bad for gut mciobisn
junk food
food whih si good for gut micorbison
fiber, i.e. plants, flut vegiaons, whore garins,
benifits of high fireb diet
imporve falce buliking reuling in an easire passesage
impiortan phyto chmea nd antioxian and fitamens
used fo rbacteiarl fermaiton, to help maintain ph, increase commnelaa bactal population, supply of short chain fatty acids
what is the stie of the most fermaitn of gut
cecum and ascingn colon
what is the ph in ascneg colon
mildy acidic
what is the main fucnitons of the right side of colon
shot chain faty acid and carbohyarte abostopon and metaboims
what is the fuciotn of the left side of the colon
slow utnrove rand liftel fuciotne ot hte carbosph mainly protein produciont
ph of descing colon
neutral
what is the harmful chemical found in desidng colon
nyh3 , h2,
what are the 3 main scfa needed in colon
buyrate
propinoate
acetate
acetate -
used fo rlipogneis and tranplorted in blood to peri;phaeral tissues
propionate
gluconeogenis in liver
satiety signalling
butyrate
intestinal peithel cell gorwht and regenationa
wher is most gi disseasi in colon
in distal colon due to higher ph and more harmful chemical s
does baceira fermaion lower ior incerase ph
lower ph
products of bacerial fermation
insulin, statch, lactae, and actaltate
what is sected in reposen ot acetat en proinate
glp 1 secteion wihc inhibs fat accumulation
what is the rulsut of propiaon adn butyrate
pyy secion , which improes insulin reisant and satiety signaling to brian
what is a ruls of butyrate
conic inflaitona nd carcinogneis - antiinlaiotn cyctokinesase
role of outer mucus layer
barrier effect, commensial bacteir close ot epitlh black adn prvets adhesi of pathsgens
role of inner mus layer
prevnet bacteria pentetion
epitheal layer reolw
if the bacteir pentre hte inner mus layer they are killed by the immeun systme
barrier effect of baceria
due to the sheer number of baceria close to the prevnet colonisaiton by ingested pathogens and inhibit gorwh of portely pathogneic bactirea
active competive exclusion
conferred by oth micorbe - microb and micrbon to host interacotin
what are cns disease linke o gut micobitoa
autiism specutm diagios
depressive disored
ms
what are gi disored likned to micorbia
ibd
ibs
nafld
cirrhosis
what are the metabolism disroed linked to microbome
insulin reisance
metabolic syndoem
obesity
cvd
what immunity disroedr sare associed with the micorbioe
allergies
autoimmune disease
cancer immuotharpy
how does hte gut microbia in ibd
reduced bacteiral diverisy
down side of ibd on micorbia
incraed diarrhea, and decreadd diesre for fibre
effect of bacterial compoin on microb
kill comensla baciera
is the effect of different antiboics differnet
yes, vancomyin is mroe powerful than clindamycin and it is more powerful then coproflaxin
what is the genral cahnge in baceria afer antiboi
firmicutes, and bacterides declina dn protetocabcteia increla
downside of protbacires
Pro inflmatory
downside of c diffe after antiboic thapry
it opens other neices follwoing antiboic shtapry, thus incrs in gorwn
cuase toin rodunion, abdo pain andf fvever
some staings are antiboics resiant
how does fecal microbla transport work
fecal sample form screened healthly donor transplanted into recpiant
donor mcrobia repopulates large inteisns, displaces c diff, prevents reinefection
what percent of fmt is effect in c diffe
90%
effect of scfa on reudcion in carbohdyresase
reduced no. of scfa
what is aproboitics
a live microcorim that when admistred in an adequete amount has a helab benfit
what is a preboitic
a subatn that selecilty utilsed by host microogaim conferring a host benifit
what role are carried out by many bacteria
competoin, barrier and reuciotn of inlaotm
what roles in the body are carried out by a limmited no. of bacteri
bioconserion diet
direction antagoism
immune stimulation
what is the ratte effect form microboiome
prodution of vitamens
why are proboics hard to judge
large no. of thtem
they are indivalist
what can preboics secte in brain
scfa which rect wiht immuen clls
health benfis of preboics
increase insuil senivy, incread barrier funion, reudced inlaoma nd lipids
increased stiety, reudced food intake
increaed imune boosint , reuicng inflaion and allergic rections
increaed claclum absopon
exampoe of preboic
b glucan fibr form oats/ barley
