Gi Pharmacolyg Flashcards

1
Q

what are parasymtic fibers rease

A

achetlycoline

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2
Q

whta do neutoransmoitrs facotrs relase

A

ach, neoepinephrine, serotoinin, puriens, no

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3
Q

endocorn hormaone examples

A

gastin and cck

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4
Q

paracirne hormone exapmes

A

histaomien and somatisn

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5
Q

nueocine homrone exapes

A

substance p

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6
Q

what are the pathways of vomiting

A

central and peipthal

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7
Q

what receptors are involed in centrla vommiting pathway

A

nk1 (neurokinin 1) , cb1 (cannabinoid 1), and h1 (histaomein)

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8
Q

what receptors are involved in pehrial vommiting pathway

A

serotonin (5ht3)
dopamine (d2) receptrs

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9
Q

wheare are the peripahl pathway found

A

in ctz - chemorectpro trigger zone - outside of blood brain barrier

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10
Q

what cuase motion sickedq

A

stimulation to the visubl nucli

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11
Q

casues of trigger to vestinucli

A

histaome and muscalinc recptorts

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12
Q

is vensibuli perua; or celntsl

A

peripheal

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13
Q

nejvre which controal stoamch vommiting reflex

A

vagal nerve

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14
Q

changes in vommitn

A

increase in heart rate
closeure of epicls
ctonracture of diaphragm

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15
Q

use of nk1 antaogis

A

vommiting due to chemo

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16
Q

use of cb1 angoinsi

A

cyctoxoic durge induced vommiting

17
Q

use of h1 antaogis

A

motin sickens and nauses

18
Q

anti musclarinici

A

motion sickness

19
Q

d2 antagonsits use

A

preganacy related nautsea dn for poor blood brain barrier drugs

20
Q

what are 5ht3 drugs

A

nausea and cytotoxic drugs, radiation, post operative conditions

21
Q

what are purgatives

A

lacatives

22
Q

what are osmatic lacatives example

A

magneism sulfat adn lactulose

23
Q

what are fecal softernes example

A

docusate souma

24
Q

what are bulk laxtive examoel

A

methycellulsoe

25
Q

what is docperidone

A

a d 2 agnats which increase lower ospgual spcier presureand increase gastic emygin

26
Q

what is metacpaide

A

increase gastic motily and emzyign

27
Q

treatment of diarrhes

A

opiate - antimsucalice, antispid,

28
Q

effecs of central opiate

A

few as it is not absoebd acrsso bbb

29
Q

way antisposamtic work in ibs

A

inibit smooth musle
ccb
direct smooth mucle reaction
anti cholign muslcalic antagoins