Gi Pharmacolyg Flashcards
what are parasymtic fibers rease
achetlycoline
whta do neutoransmoitrs facotrs relase
ach, neoepinephrine, serotoinin, puriens, no
endocorn hormaone examples
gastin and cck
paracirne hormone exapmes
histaomien and somatisn
nueocine homrone exapes
substance p
what are the pathways of vomiting
central and peipthal
what receptors are involed in centrla vommiting pathway
nk1 (neurokinin 1) , cb1 (cannabinoid 1), and h1 (histaomein)
what receptors are involved in pehrial vommiting pathway
serotonin (5ht3)
dopamine (d2) receptrs
wheare are the peripahl pathway found
in ctz - chemorectpro trigger zone - outside of blood brain barrier
what cuase motion sickedq
stimulation to the visubl nucli
casues of trigger to vestinucli
histaome and muscalinc recptorts
is vensibuli perua; or celntsl
peripheal
nejvre which controal stoamch vommiting reflex
vagal nerve
changes in vommitn
increase in heart rate
closeure of epicls
ctonracture of diaphragm
use of nk1 antaogis
vommiting due to chemo
use of cb1 angoinsi
cyctoxoic durge induced vommiting
use of h1 antaogis
motin sickens and nauses
anti musclarinici
motion sickness
d2 antagonsits use
preganacy related nautsea dn for poor blood brain barrier drugs
what are 5ht3 drugs
nausea and cytotoxic drugs, radiation, post operative conditions
what are purgatives
lacatives
what are osmatic lacatives example
magneism sulfat adn lactulose
what are fecal softernes example
docusate souma
what are bulk laxtive examoel
methycellulsoe
what is docperidone
a d 2 agnats which increase lower ospgual spcier presureand increase gastic emygin
what is metacpaide
increase gastic motily and emzyign
treatment of diarrhes
opiate - antimsucalice, antispid,
effecs of central opiate
few as it is not absoebd acrsso bbb
way antisposamtic work in ibs
inibit smooth musle
ccb
direct smooth mucle reaction
anti cholign muslcalic antagoins
